Glycyrrhizic Acid Mitigates Tripterygium-Glycoside-Tablet-Induced Acute Liver Injury via PKM2 Regulated Oxidative Stress

• Published in: Metabolites Vol. 12; no. 11; p. 1128
• Main Authors: Wang, Qixin, Huang, Yuwen, Li, Yu, Zhang, Luyun, Tang, Huan, Zhang, Junzhe, Cheng, Guangqing, Zhao, Minghong, Lu, Tianming, Zhang, Qian, Luo, Piao, Zhu, Yinhua, Xia, Fei, Zhang, Ying, Liu, Dandan, Wang, Chen, Li, Haiyan, Qiu, Chong, Wang, Jigang, Guo, Qiuyan
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.11.2022; MDPI
• Subjects: activity-based protein profiling; Alanine transaminase; Alkaline phosphatase; Apoptosis; Aspartate aminotransferase; Bioengineering; Biotechnology; Care and treatment; Catalase; Cell culture; Cysteine; cysteine-specific probe; Cytokines; Drugs; Enzymatic activity; Flow cytometry; Glutathione; Glycosides; glycyrrhizic acid; Health aspects; IL-1β; Interleukin 6; L-Lactate dehydrogenase; Labeling; Laboratory animals; Lactic acid; Liver; Medical research; Metabolites; Oxidative stress; Patient outcomes; Proteins; pyruvate kinase; Rheumatoid arthritis; Superoxide dismutase; Thunder god vine; Tripterygium; tripterygium glycoside tablet; Tumor necrosis factor-α; China; Beijing China; United States > US

Tripterygium glycoside tablet (TGT), as a common clinical drug, can easily cause liver damage due to the narrow therapeutic window. Glycyrrhizic acid (GA) has a hepatoprotective effect, but the characteristics and mechanism of GA’s impact on TGT-induced acute liver injury by regulating oxidative str...