Precise Delineation and Transcriptional Characterization of Bovine Blood Dendritic-Cell and Monocyte Subsets

• Published in: Frontiers in immunology Vol. 9; p. 2505
• Main Authors: Talker, Stephanie C, Baumann, Arnaud, Barut, G Tuba, Keller, Irene, Bruggmann, Rémy, Summerfield, Artur
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 30.10.2018
• Subjects: cattle; cDC1; cDC2; dendritic cells; Immunology; monocytes; transcriptome; cDC1; monocytes; dendritic cells; transcriptome; cattle; cDC2; pDC

A clear-cut delineation of bovine dendritic cells (DC) from monocytes has proved challenging, given the high phenotypic and functional plasticity of these innate immune cells and the marked phenotypic differences between species. Here, we demonstrate that, based on expression of Flt3, CD172a, CD13,...