The Role of Myeloid Cell Activation and Arginine Metabolism in the Pathogenesis of Virus-Induced Diseases

• Published in: Frontiers in immunology Vol. 5; p. 428
• Main Authors: Burrack, Kristina S., Morrison, Thomas E.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 08.09.2014
• Subjects: Arginase; Immunity, Cellular; Immunology; iNOS; Macrophages; Viral pathogenicity; iNOS; macrophages; viral pathogenicity; immunity; arginase; cellular

WHEN AN ANTIVIRAL IMMUNE RESPONSE IS GENERATED, A BALANCE MUST BE REACHED BETWEEN TWO OPPOSING PATHWAYS: the production of proinflammatory and cytotoxic effectors that drive a robust antiviral immune response to control the infection and regulators that function to limit or blunt an excessive immune...