Activation of AMPK-SIRT3 signaling is chondroprotective by preserving mitochondrial DNA integrity and function

• Published in: Osteoarthritis and cartilage Vol. 26; no. 11; pp. 1539 - 1550
• Main Authors: Chen, L.-Y., Wang, Y., Terkeltaub, R., Liu-Bryan, R.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2018
• Subjects: AMPK; Mitochondrial DNA; OGG1; Oxidative stress; SIRT3; SOD2; Oxidative stress; AMPK; Mitochondrial DNA; SOD2; OGG1; SIRT3

In osteoarthritis (OA), articular chondrocytes manifest mitochondrial damage, including mitochondrial DNA 4977-bp (mtDNA4977) deletion that impairs mitochondrial function. OA chondrocytes have decreased activity of AMPK, an energy biosensor that promotes mitochondrial biogenesis. Here, we tested if...