The Role of Transient Receptor Potential Vanilloid 1 in Common Diseases of the Digestive Tract and the Cardiovascular and Respiratory System

Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely expressed in sensory nerve fibers and nonneuronal cells, including certain vascular endothelial cells and smooth mus...

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Published inFrontiers in physiology Vol. 10; p. 1064
Main Authors Du, Qian, Liao, Qiushi, Chen, Changmei, Yang, Xiaoxu, Xie, Rui, Xu, Jingyu
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 21.08.2019
Subjects
cardiovascular system
digestive tract
functional dyspepsia
irritable bowel syndrome
Physiology
respiratory system
transient receptor potential vanilloid 1
respiratory system
cardiovascular system
digestive tract
functional dyspepsia
irritable bowel syndrome
transient receptor potential vanilloid 1
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Abstract Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely expressed in sensory nerve fibers and nonneuronal cells, including certain vascular endothelial cells and smooth muscle cells. The activation of TRPV1 may be involved in the regulation of various physiological functions, such as the release of inflammatory mediators in the body, gastrointestinal motility function, and temperature regulation. In recent years, a large number of studies have revealed that TRPV1 plays an important role in the physiological and pathological conditions of the digestive system, cardiovascular system, and respiratory system, but there is no systematic report on TRPV1. The objective of this review is to explain the function and effects of TRPV1 on specific diseases, such as irritable bowel syndrome, hypertension, and asthma, and to further investigate the intrinsic relationship between the expression and function of TRPV1 in those diseases to find new therapeutic targets for the cure of related diseases.
AbstractList Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely expressed in sensory nerve fibers and nonneuronal cells, including certain vascular endothelial cells and smooth muscle cells. The activation of TRPV1 may be involved in the regulation of various physiological functions, such as the release of inflammatory mediators in the body, gastrointestinal motility function, and temperature regulation. In recent years, a large number of studies have revealed that TRPV1 plays an important role in the physiological and pathological conditions of the digestive system, cardiovascular system, and respiratory system, but there is no systematic report on TRPV1. The objective of this review is to explain the function and effects of TRPV1 on specific diseases, such as irritable bowel syndrome, hypertension, and asthma, and to further investigate the intrinsic relationship between the expression and function of TRPV1 in those diseases to find new therapeutic targets for the cure of related diseases.
Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely expressed in sensory nerve fibers and nonneuronal cells, including certain vascular endothelial cells and smooth muscle cells. The activation of TRPV1 may be involved in the regulation of various physiological functions, such as the release of inflammatory mediators in the body, gastrointestinal motility function, and temperature regulation. In recent years, a large number of studies have revealed that TRPV1 plays an important role in the physiological and pathological conditions of the digestive system, cardiovascular system, and respiratory system, but there is no systematic report on TRPV1. The objective of this review is to explain the function and effects of TRPV1 on specific diseases, such as irritable bowel syndrome, hypertension, and asthma, and to further investigate the intrinsic relationship between the expression and function of TRPV1 in those diseases to find new therapeutic targets for the cure of related diseases.Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely expressed in sensory nerve fibers and nonneuronal cells, including certain vascular endothelial cells and smooth muscle cells. The activation of TRPV1 may be involved in the regulation of various physiological functions, such as the release of inflammatory mediators in the body, gastrointestinal motility function, and temperature regulation. In recent years, a large number of studies have revealed that TRPV1 plays an important role in the physiological and pathological conditions of the digestive system, cardiovascular system, and respiratory system, but there is no systematic report on TRPV1. The objective of this review is to explain the function and effects of TRPV1 on specific diseases, such as irritable bowel syndrome, hypertension, and asthma, and to further investigate the intrinsic relationship between the expression and function of TRPV1 in those diseases to find new therapeutic targets for the cure of related diseases.
Author Liao, Qiushi
Chen, Changmei
Xie, Rui
Du, Qian
Yang, Xiaoxu
Xu, Jingyu
AuthorAffiliation Department of Gastroenterology, Affiliated Hospital to Zunyi Medical University , Zunyi , China
AuthorAffiliation_xml – name: Department of Gastroenterology, Affiliated Hospital to Zunyi Medical University , Zunyi , China
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Keywords respiratory system
cardiovascular system
digestive tract
functional dyspepsia
irritable bowel syndrome
transient receptor potential vanilloid 1
Language English
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Edited by: Matthew Zahner, East Tennessee State University, United States
Reviewed by: Jason N. Peart, Griffith University, Australia; Zhiming Zhu, Daping Hospital, China; Efstratios Stratikos, National Centre of Scientific Research Demokritos, Greece; Shaolei Teng, Howard University, United States
This article was submitted to Integrative Physiology, a section of the journal Frontiers in Physiology
These authors have contributed equally to this work
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Snippet Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor potential vanilloid (TRPV) channel family, is a nonselective...
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SubjectTerms cardiovascular system
digestive tract
functional dyspepsia
irritable bowel syndrome
Physiology
respiratory system
transient receptor potential vanilloid 1
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Title The Role of Transient Receptor Potential Vanilloid 1 in Common Diseases of the Digestive Tract and the Cardiovascular and Respiratory System
URI https://www.ncbi.nlm.nih.gov/pubmed/31496955
https://www.proquest.com/docview/2287516482
https://pubmed.ncbi.nlm.nih.gov/PMC6712094
https://doaj.org/article/62d461b344484a1bb78aea6f919e0146
Volume 10
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