Avian eggshell formation reveals a new paradigm for vertebrate mineralization via vesicular amorphous calcium carbonate

• Published in: The Journal of biological chemistry Vol. 295; no. 47; pp. 15853 - 15869
• Main Authors: Stapane, Lilian, Le Roy, Nathalie, Ezagal, Jacky, Rodriguez-Navarro, Alejandro B., Labas, Valérie, Combes-Soia, Lucie, Hincke, Maxwell T., Gautron, Joël
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.11.2020; American Society for Biochemistry and Molecular Biology
• Subjects: ACC transport; Agricultural sciences; Animal production studies; Animals; avian eggshell; Avian Proteins - metabolism; Biochemistry; Biochemistry, Molecular Biology; Biomineralization; Calcification, Physiologic; Calcium Carbonate - metabolism; calcium transport; calcium-binding protein; Chickens - metabolism; Egg Shell - metabolism; Egg Shell - ultrastructure; extracellular matrix protein; Extracellular Matrix Proteins - metabolism; extracellular vesicle; extracellular vesicles; Extracellular Vesicles - metabolism; Extracellular Vesicles - ultrastructure; Female; Genomics; Glycobiology and Extracellular Matrices; Life Sciences; matrix proteins; protein targeting; Zootechny; matrix proteins; extracellular matrix protein; extracellular vesicles; calcium-binding protein; ACC transport; Biomineralization; protein targeting; avian eggshell; extracellular vesicle; calcium transport

Amorphous calcium carbonate (ACC) is an unstable mineral phase, which is progressively transformed into aragonite or calcite in biomineralization of marine invertebrate shells or avian eggshells, respectively. We have previously proposed a model of vesicular transport to provide stabilized ACC in ch...