5-HT 2 receptor mediates high-fat diet-induced hepatic steatosis and very low density lipoprotein overproduction in rats

• Published in: Obesity research & clinical practice Vol. 12; no. 1; pp. 16 - 28
• Main Authors: Li, Xin, Guo, Keke, Li, Tao, Ma, Shaoxin, An, Shanshan, Wang, Shanshan, Di, Jiao, He, Siyu, Fu, Jihua
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.01.2018
• Subjects: 5-HT 2 receptor; 5-HT synthesis; Animals; Cholesterol, VLDL - biosynthesis; Cholesterol, VLDL - blood; Diet, High-Fat; Disease Models, Animal; Endocrinology & Metabolism; Fatty Liver - blood; Fatty Liver - metabolism; Hepatic lipid abnormality; Internal Medicine; Lipoproteins, VLDL - biosynthesis; Lipoproteins, VLDL - blood; Liver - metabolism; Male; Mammalian target of rapamycin; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT2 - metabolism; Up-Regulation; Hepatic lipid abnormality; 5-HT 2 receptor; Mammalian target of rapamycin; 5-HT synthesis

5-HT has been shown to mediate abnormality of hepatic lipid metabolism through activation of mammalian target of rapamycin (mTOR). However, it is unclear whether 5-HT is directly involved in high-fat diet (HFD)-induced hepatic steatosis. Male rats were allocated into seven groups with control, eithe...