Daily Viral Kinetics and Innate and Adaptive Immune Response Assessment in COVID-19: a Case Series

• Published in: mSphere Vol. 5; no. 6
• Main Authors: Vetter, Pauline, Eberhardt, Christiane S., Meyer, Benjamin, Martinez Murillo, Paola Andrea, Torriani, Giulia, Pigny, Fiona, Lemeille, Sylvain, Cordey, Samuel, Laubscher, Florian, Vu, Diem-Lan, Calame, Adrien, Schibler, Manuel, Jacquerioz, Frederique, Blanchard-Rohner, Géraldine, Siegrist, Claire-Anne, Kaiser, Laurent, Didierlaurent, Arnaud M., Eckerle, Isabella
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 11.11.2020
• Subjects: Adaptive Immunity; Adult; Aged; Antibodies, Viral - metabolism; antibody response; Betacoronavirus - immunology; Betacoronavirus - isolation & purification; Biomarkers - metabolism; Clinical Laboratory Techniques; Clinical Science and Epidemiology; Coronavirus Infections - diagnosis; Coronavirus Infections - immunology; Coronavirus Infections - virology; COVID-19; COVID-19 Testing; cytokines; Cytokines - metabolism; Humans; immunity; Immunity, Innate; Kinetics; Middle Aged; Pandemics; Pneumonia, Viral - diagnosis; Pneumonia, Viral - immunology; Pneumonia, Viral - virology; SARS-CoV-2; Severity of Illness Index; Viral Load; Virus Shedding; COVID-19; SARS-CoV-2; cytokines; antibody response; viral load; immunity

This work is particularly important because it simultaneously assessed the virology, immunology, and clinical presentation of the same subjects, whereas other studies assess these separately. We describe the detailed viral and immune profiles of the first five patients infected by SARS-CoV-2 and qua...