Redirection of Epithelial Immune Responses by Short-Chain Fatty Acids through Inhibition of Histone Deacetylases

• Published in: Frontiers in immunology Vol. 6; p. 554
• Main Authors: Lin, May Young, de Zoete, Marcel R., van Putten, Jos P. M., Strijbis, Karin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 03.11.2015
• Subjects: Butyrate; Flagellin; HDAC; histone acetylation; Immunology; NF-κB; Toll-Like Receptors; NF-κB; butyrate; toll-like receptors; SCFAs; flagellin; TLR5; histone acetylation; HDAC

Short-chain fatty acids (SCFAs) are products of microbial fermentation that are important for intestinal epithelial health. Here, we describe that SCFAs have rapid and reversible effects on toll-like receptor (TLR) responses in epithelial cells. Incubation of HEK293 or HeLa epithelial cells with the...