Respiratory Disease following Viral Lung Infection Alters the Murine Gut Microbiota

• Published in: Frontiers in immunology Vol. 9; p. 182
• Main Authors: Groves, Helen T, Cuthbertson, Leah, James, Phillip, Moffatt, Miriam F, Cox, Michael J, Tregoning, John S
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 12.02.2018
• Subjects: Animals; Bacteria - classification; Bacteria - isolation & purification; Bacteroidetes; Bacteroidetes - isolation & purification; Female; Firmicutes; Firmicutes - isolation & purification; Gastrointestinal Microbiome; gut microbiota; Immunology; influenza; Influenza Vaccines - administration & dosage; Lipocalin-2 - analysis; Lung - virology; Mice; Mice, Inbred BALB C; Mucin 5ac; Mucin 5AC - analysis; Orthomyxoviridae; Orthomyxoviridae Infections - complications; respiratory syncytial virus infections; Respiratory Syncytial Virus Infections - complications; Respiratory Syncytial Viruses; Respiratory Tract Infections - complications; Respiratory Tract Infections - virology; RNA, Ribosomal, 16S; Vaccines, Attenuated - administration & dosage; influenza; Bacteroidetes; Mucin 5ac; respiratory syncytial virus infections; gut microbiota; Firmicutes

Alterations in the composition of the gut microbiota have profound effects on human health. Consequently, there is great interest in identifying, characterizing, and understanding factors that initiate these changes. Despite their high prevalence, studies have only recently begun to investigate how...