Detecting Neuroimaging Biomarkers for Psychiatric Disorders: Sample Size Matters

• Published in: Frontiers in psychiatry Vol. 7; p. 50
• Main Authors: Schnack, Hugo G., Kahn, René S.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 31.03.2016
• Subjects: classification and prediction; effect size; heterogeneity; machine learning; Neuroimaging; Psychiatry; Schizophrenia; schizophrenia; effect size; machine learning; classification and prediction; heterogeneity; neuroimaging

In a recent review, it was suggested that much larger cohorts are needed to prove the diagnostic value of neuroimaging biomarkers in psychiatry. While within a sample, an increase of diagnostic accuracy of schizophrenia (SZ) with number of subjects (N) has been shown, the relationship between N and...