Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity

• Published in: Frontiers in pharmacology Vol. 9; p. 147
• Main Authors: Lv, Hongming, Xiao, Qingfei, Zhou, Junfeng, Feng, Haihua, Liu, Guowen, Ci, Xinxin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 23.03.2018
• Subjects: acetaminophen; hepatotoxicity; licochalcone A; Nrf2; oxidative stress; Pharmacology; acetaminophen; licochalcone A; Nrf2; hepatotoxicity; oxidative stress

Acetaminophen (APAP) overdose-induced fatal hepatotoxicity is majorly characterized by overwhelmingly increased oxidative stress while enhanced nuclear factor-erythroid 2-related factor 2 (Nrf2) is involved in prevention of hepatotoxicity. Although Licochalcone A (Lico A) upregulates Nrf2 signaling...