Molecular Pathways in Peritoneal Mesothelioma: A Minireview of New Insights

Mesothelioma is a rare malignant neoplasm with poor survival. It mainly affects the pleura (90%) but can arise in all serous cavities: peritoneum (5-10%), pericardium and tunica vaginalis testis (<1%). The onset of pleural mesothelioma is strictly related to asbestos exposure with a long latency...

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Published inFrontiers in oncology Vol. 12; p. 823839
Main Authors Fortarezza, Francesco, Pezzuto, Federica, Marzullo, Andrea, Cavone, Domenica, Romano, Daniele Egidio, d'Amati, Antonio, Serio, Gabriella, Vimercati, Luigi
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 10.02.2022
Subjects
asbestos
malignant mesothelioma
molecular pathways
Oncology
peritoneal mesothelioma
prognostic factors
prognostic factors
asbestos
molecular pathways
malignant mesothelioma
peritoneal mesothelioma
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Abstract Mesothelioma is a rare malignant neoplasm with poor survival. It mainly affects the pleura (90%) but can arise in all serous cavities: peritoneum (5-10%), pericardium and tunica vaginalis testis (<1%). The onset of pleural mesothelioma is strictly related to asbestos exposure with a long latency time. The causal link with asbestos has also been suggested for peritoneal mesothelioma, while the importance of exposure in the onset of pericardial and tunica vaginalis testis mesotheliomas is not well known. Mesothelioma remains an aggressive and fatal disease with a five-year mortality rate higher than 95%. However, new therapeutic approaches based on molecular-targeted and immunomodulatory therapies are being explored but have conflicting results. In this context, the identification of critical targets appears mandatory. Awareness of the molecular and physiological changes leading to the neoplastic degeneration of mesothelial cells and the identification of gene mutations, epigenetic alterations, gene expression profiles and altered pathways could be helpful for selecting targetable mechanisms and molecules. In this review, we aimed to report recent research in the last 20 years focusing on the molecular pathways and prognostic factors in peritoneal mesothelioma and their possible diagnostic and therapeutic implications.
AbstractList Mesothelioma is a rare malignant neoplasm with poor survival. It mainly affects the pleura (90%) but can arise in all serous cavities: peritoneum (5-10%), pericardium and tunica vaginalis testis (<1%). The onset of pleural mesothelioma is strictly related to asbestos exposure with a long latency time. The causal link with asbestos has also been suggested for peritoneal mesothelioma, while the importance of exposure in the onset of pericardial and tunica vaginalis testis mesotheliomas is not well known. Mesothelioma remains an aggressive and fatal disease with a five-year mortality rate higher than 95%. However, new therapeutic approaches based on molecular-targeted and immunomodulatory therapies are being explored but have conflicting results. In this context, the identification of critical targets appears mandatory. Awareness of the molecular and physiological changes leading to the neoplastic degeneration of mesothelial cells and the identification of gene mutations, epigenetic alterations, gene expression profiles and altered pathways could be helpful for selecting targetable mechanisms and molecules. In this review, we aimed to report recent research in the last 20 years focusing on the molecular pathways and prognostic factors in peritoneal mesothelioma and their possible diagnostic and therapeutic implications.
Author Cavone, Domenica
Fortarezza, Francesco
Vimercati, Luigi
Pezzuto, Federica
d'Amati, Antonio
Romano, Daniele Egidio
Marzullo, Andrea
Serio, Gabriella
AuthorAffiliation 3 Department of Interdisciplinary Medicine, Occupational Health Unit, University of Bari , Bari , Italy
1 Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Pathology Unit, University of Padova , Padova , Italy
2 Department of Emergency and Organ Transplantation, Pathology Unit, University of Bari , Bari , Italy
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Cites_doi 10.1200/JCO.19.02085
10.1200/JCO.2018.78.5204
10.1186/s12881-018-0651-4
10.1111/his.12779
10.1097/PAS.0000000000001359
10.1186/s13073-019-0620-3
10.1097/PGP.0000000000000762
10.1002/cncr.25555
10.1093/annonc/mdy086
10.3390/ijms20225817
10.5858/arpa.2017-0124-RA
10.3390/ijms21176342
10.1093/carcin/bgt166
10.1245/ASO.2006.05.041
10.1002/onco.13714
10.1200/PO.19.00048
10.21037/jtd.2018.12.14
10.1002/cncr.28875
10.1186/1477-7819-8-88
10.1016/j.ejca.2010.06.130
10.1002/cam4.656
10.1136/esmoopen-2016-000101
10.1200/JCO.2021.39.15_suppl.8558
10.1002/cncr.33145
10.1378/chest.117.2.486
10.3390/jcm8030414
10.1101/mcs.a003566
10.1002/gcc.22068
10.1136/oemed-2019-105826
10.12659/AJCR.903548
10.1080/15384047.2016.1145850
10.1016/j.jtho.2016.12.019
10.1016/j.ejso.2020.02.011
10.3892/or.2012.1725
10.1038/s41379-019-0371-0
10.1136/oem.51.12.804
10.1097/PAS.0000000000000864
10.1200/JCO.2020.38.15_suppl.9058
10.3389/fonc.2021.653497
10.5858/arpa.2012-0214-OA
10.1007/978-981-15-9158-7_2
10.1186/s12967-015-0485-1
10.1002/path.1700120212
10.1038/modpathol.2015.121
10.1007/s13277-012-0462-8
10.1016/j.humpath.2018.07.033
10.3109/01913123.2016.1170085
10.1038/onc.2012.5
10.1038/s41379-020-0588-y
10.1038/s41416-020-01130-x
10.1016/j.ebiom.2018.12.025
10.1038/modpathol.2016.188
10.3390/diagnostics10060386
10.3322/caac.21572
10.1186/s12885-015-1010-x
10.1097/MD.0000000000005447
10.1038/s41379-018-0127-2
10.3390/ijms17050739
10.1097/PAS.0000000000001418
10.1016/j.lungcan.2018.10.012
10.5808/gi.21019
10.1038/s41416-021-01462-2
10.1016/S2213-2600(20)30390-8
10.1001/jamaoncol.2017.2918
10.18632/oncotarget.12262
10.3390/ijms18081818
10.1371/journal.pone.0119689
10.3390/cancers13092278
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Copyright Copyright © 2022 Fortarezza, Pezzuto, Marzullo, Cavone, Romano, d’Amati, Serio and Vimercati.
Copyright © 2022 Fortarezza, Pezzuto, Marzullo, Cavone, Romano, d’Amati, Serio and Vimercati 2022 Fortarezza, Pezzuto, Marzullo, Cavone, Romano, d’Amati, Serio and Vimercati
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Keywords prognostic factors
asbestos
molecular pathways
malignant mesothelioma
peritoneal mesothelioma
Language English
License Copyright © 2022 Fortarezza, Pezzuto, Marzullo, Cavone, Romano, d’Amati, Serio and Vimercati.
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Reviewed by: Sabahattin Cömertpay, Kahramanmaras Sütçü Imam University, Turkey
This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Oncology
These authors share first authorship
Edited by: Dario Palmieri, The Ohio State University, United States
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References Carbone (B2) 2019; 69
Perrone (B20) 2010; 46
White (B62) 2021; 124
Stallone (B52) 2017; 18
Leblay (B28) 2017; 12
Sciarrillo (B34) 2019; 39
Glass Zauderer (B64) 2020
Obacz (B70) 2021; 125
Varghese (B21) 2011; 117
Hama (B39) 2012; 33
Husain (B5) 2013; 137
Desmeules (B26) 2017; 41
Consonni (B7) 2019; 76
Sheffield (B41) 2015; 10
Löffler (B46) 2018; 19
Panou (B31) 2018; 36
Shrestha (B33) 2019; 11
Husain (B4) 2018; 142
Farioli (B15) 2016; 5
Smith-Hannah (B49) 2019; 83
Miller (B1) 1908; 12
Brich (B36) 2020; 33
Serio (B57) 2016; 9
Calabrese (B59) 2019; 8
Lai (B42) 2016; 17
Kalra (B22) 2012; 27
Fennell (B63) 2021; 9
Hung (B29) 2018; 4
Pezzuto (B58) 2019; 11
Rüschoff (B48) 2019; 3
Malpica (B14) 2021; 41
Miyagawa (B51) 2021; 26
Hassan (B68) 2014; 120
Foster (B19) 2010; 8
Glass (B50) 2020; 44
Pezzuto (B37) 2020; 10
Vanni (B43) 2016; 95
Belfiore (B32) 2019; 20
Kusamura (B6) 2021; 47
Spirtas (B8) 1994; 51
Jaurand (B17) 2021
Hassan (B67) 2020; 126
Lund-Andersen (B47) 2019; 5
Vimercati (B12) 2021; 13
Mizuno (B66) 2012; 31
Chao (B40) 2015; 15
de Ridder (B11) 2016; 40
Fennell (B65) 2021
Hung (B38) 2020; 33
Dolly (B53) 2017; 2
Borczuk (B56) 2016; 17
Mahfuz (B18) 2021; 19
Serio (B45) 2017; 18
Dodson (B10) 2000; 117
Hassan (B69) 2020; 38
Ugurluer (B25) 2016; 36
Singhi (B55) 2016; 29
Pasello (B61) 2018; 29
Cakiroglu (B16) 2020; 21
Alakus (B23) 2015; 13
Panagopoulos (B54) 2013; 52
Pezzuto (B60) 2021; 11
Pavlisko (B3) 2020; 44
Bozzi (B24) 2016; 7
Brigand (B9) 2006; 13
Stevers (B35) 2019; 32
Joseph (B27) 2017; 30
Sekido (B13) 2013; 34
Serio (B30) 2018; 126
Loharamtaweethong (B44) 2016; 68
References_xml – volume: 38
  year: 2020
  ident: B69
  article-title: First-In-Human, Multicenter, Phase I Dose-Escalation and Expansion Study of Anti-Mesothelin Antibody-Drug Conjugate Anetumab Ravtansine in Advanced or Metastatic Solid Tumors
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.19.02085
  contributor:
    fullname: Hassan
– volume: 36
  year: 2018
  ident: B31
  article-title: Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma
  publication-title: J Clin Oncol
  doi: 10.1200/JCO.2018.78.5204
  contributor:
    fullname: Panou
– volume: 19
  start-page: 144
  year: 2018
  ident: B46
  article-title: First Case Report of Malignant Peritoneal Mesothelioma and Oral Verrucous Carcinoma in a Patient With a Germline PTEN Mutation: A Combination of Extremely Rare Diseases With Probable Further Implications
  publication-title: BMC Med Genet
  doi: 10.1186/s12881-018-0651-4
  contributor:
    fullname: Löffler
– volume: 68
  year: 2016
  ident: B44
  article-title: Anaplastic Lymphoma Kinase (ALK) Translocation in Paediatric Malignant Peritoneal Mesothelioma: A Case Report of Novel ALK-Related Tumour Spectrum
  publication-title: Histopathol
  doi: 10.1111/his.12779
  contributor:
    fullname: Loharamtaweethong
– volume: 44
  year: 2020
  ident: B50
  article-title: Molecular Analysis of a Patient With Neurofibromatosis 2 (NF2) and Peritoneal Malignant Mesothelioma
  publication-title: Am J Surg Pathol
  doi: 10.1097/PAS.0000000000001359
  contributor:
    fullname: Glass
– volume: 11
  start-page: 8
  year: 2019
  ident: B33
  article-title: BAP1 Haploinsufficiency Predicts a Distinct Immunogenic Class of Malignant Peritoneal Mesothelioma
  publication-title: Genome Med
  doi: 10.1186/s13073-019-0620-3
  contributor:
    fullname: Shrestha
– volume: 41
  start-page: 59
  year: 2021
  ident: B14
  article-title: Malignant Peritoneal Mesothelioma Associated With Endometriosis: A Clinicopathologic Study of 15 Cases
  publication-title: Int J Gynecol Pathol
  doi: 10.1097/PGP.0000000000000762
  contributor:
    fullname: Malpica
– volume: 117
  year: 2011
  ident: B21
  article-title: Activation of the Phosphoinositide-3-Kinase and Mammalian Target of Rapamycin Signaling Pathways are Associated With Shortened Survival in Patients With Malignant Peritoneal Mesothelioma
  publication-title: Cancer
  doi: 10.1002/cncr.25555
  contributor:
    fullname: Varghese
– volume: 29
  year: 2018
  ident: B61
  article-title: Malignant Pleural Mesothelioma Immune Microenvironment and Checkpoint Expression: Correlation With Clinical-Pathological Features and Intratumor Heterogeneity Over Time
  publication-title: Ann Oncol
  doi: 10.1093/annonc/mdy086
  contributor:
    fullname: Pasello
– volume: 20
  start-page: 5817
  year: 2019
  ident: B32
  article-title: Molecular Signatures for Combined Targeted Treatments in Diffuse Malignant Peritoneal Mesothelioma
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms20225817
  contributor:
    fullname: Belfiore
– volume: 142
  start-page: 89
  year: 2018
  ident: B4
  article-title: Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group
  publication-title: Arch Pathol Lab Med
  doi: 10.5858/arpa.2017-0124-RA
  contributor:
    fullname: Husain
– volume: 21
  start-page: 6342
  year: 2020
  ident: B16
  article-title: Genomics and Functional Genomics of Malignant Pleural Mesothelioma
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms21176342
  contributor:
    fullname: Cakiroglu
– volume: 34
  year: 2013
  ident: B13
  article-title: Molecular Pathogenesis of Malignant Mesothelioma
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgt166
  contributor:
    fullname: Sekido
– volume: 13
  year: 2006
  ident: B9
  article-title: Peritoneal Mesothelioma Treated by Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemotherapy: Results of a Prospective Study
  publication-title: Ann Surg Oncol
  doi: 10.1245/ASO.2006.05.041
  contributor:
    fullname: Brigand
– volume: 26
  year: 2021
  ident: B51
  article-title: A Novel Malignant Peritoneal Mesothelioma With STRN Exon 2 and ALK Exon 20: A Case Report and Literature Review
  publication-title: Oncologist
  doi: 10.1002/onco.13714
  contributor:
    fullname: Miyagawa
– volume: 3
  year: 2019
  ident: B48
  article-title: STRN-ALK Rearranged Malignant Peritoneal Mesothelioma With Dramatic Response Following Ceritinib Treatment
  publication-title: JCO Precis Oncol
  doi: 10.1200/PO.19.00048
  contributor:
    fullname: Rüschoff
– volume: 11
  year: 2019
  ident: B58
  article-title: Are There Any Theranostic Biomarkers in Small Cell Lung Carcinoma
  publication-title: J Thorac Dis
  doi: 10.21037/jtd.2018.12.14
  contributor:
    fullname: Pezzuto
– volume: 120
  year: 2014
  ident: B68
  article-title: Phase 1 Study of the Antimesothelin Immunotoxin SS1P in Combination With Pemetrexed and Cisplatin for Front-Line Therapy of Pleural Mesothelioma and Correlation of Tumor Response With Serum Mesothelin, Megakaryocyte Potentiating Factor, and Cancer Antigen 125
  publication-title: Cancer
  doi: 10.1002/cncr.28875
  contributor:
    fullname: Hassan
– volume: 8
  start-page: 88
  year: 2010
  ident: B19
  article-title: Clinical Implications of Novel Activating EGFR Mutations in Malignant Peritoneal Mesothelioma
  publication-title: World J Surg Oncol
  doi: 10.1186/1477-7819-8-88
  contributor:
    fullname: Foster
– volume: 46
  year: 2010
  ident: B20
  article-title: Receptor Tyrosine Kinase and Downstream Signalling Analysis in Diffuse Malignant Peritoneal Mesothelioma
  publication-title: Eur J Cancer
  doi: 10.1016/j.ejca.2010.06.130
  contributor:
    fullname: Perrone
– volume: 5
  year: 2016
  ident: B15
  article-title: Radiation-Induced Mesothelioma Among Long-Term Solid Cancer Survivors: A Longitudinal Analysis of SEER Database
  publication-title: Cancer Med
  doi: 10.1002/cam4.656
  contributor:
    fullname: Farioli
– volume: 2
  year: 2017
  ident: B53
  article-title: Indolent Peritoneal Mesothelioma: PI3K-mTOR Inhibitors as a Novel Therapeutic Strategy
  publication-title: ESMO Open
  doi: 10.1136/esmoopen-2016-000101
  contributor:
    fullname: Dolly
– year: 2021
  ident: B65
  article-title: A Phase II Trial of Abemaciclib in Patients With P16ink4a Negative, Relapsed Mesothelioma
  publication-title: J Clin Onc
  doi: 10.1200/JCO.2021.39.15_suppl.8558
  contributor:
    fullname: Fennell
– volume: 126
  year: 2020
  ident: B67
  article-title: Phase 1 Study of the Immunotoxin LMB-100 in Patients With Mesothelioma and Other Solid Tumors Expressing Mesothelin
  publication-title: Cancer
  doi: 10.1002/cncr.33145
  contributor:
    fullname: Hassan
– volume: 117
  year: 2000
  ident: B10
  article-title: Asbestos in Extrapulmonary Sites: Omentum and Mesentery
  publication-title: Chest
  doi: 10.1378/chest.117.2.486
  contributor:
    fullname: Dodson
– volume: 8
  start-page: 414
  year: 2019
  ident: B59
  article-title: Are There New Biomarkers in Tissue and Liquid Biopsies for the Early Detection of Non-Small Cell Lung Cancer
  publication-title: J Clin Med
  doi: 10.3390/jcm8030414
  contributor:
    fullname: Calabrese
– volume: 5
  year: 2019
  ident: B47
  article-title: Integrative Genomic Analysis of Peritoneal Malignant Mesothelioma: Understanding a Case With Extraordinary Chemotherapy Response
  publication-title: Cold Spring Harb Mol Case Stud
  doi: 10.1101/mcs.a003566
  contributor:
    fullname: Lund-Andersen
– volume: 52
  year: 2013
  ident: B54
  article-title: RNA Sequencing Identifies Fusion of the EWSR1 and YY1 Genes in Mesothelioma With T(14;22)(Q32;Q12)
  publication-title: Genes Chromosomes Cancer
  doi: 10.1002/gcc.22068
  contributor:
    fullname: Panagopoulos
– volume: 76
  year: 2019
  ident: B7
  article-title: Peritoneal Mesothelioma and Asbestos Exposure: A Population-Based Case-Control Study in Lombardy, Italy
  publication-title: Occup Environ Med
  doi: 10.1136/oemed-2019-105826
  contributor:
    fullname: Consonni
– volume: 18
  year: 2017
  ident: B52
  article-title: Rapamycin Treatment for Benign Multicystic Peritoneal Mesothelioma: A Rare Disease With a Difficult Management
  publication-title: Am J Case Rep
  doi: 10.12659/AJCR.903548
  contributor:
    fullname: Stallone
– volume: 17
  year: 2016
  ident: B56
  article-title: Genome-Wide Analysis of Abdominal and Pleural Malignant Mesothelioma With DNA Arrays Reveals Both Common and Distinct Regions of Copy Number Alteration
  publication-title: Cancer Biol Ther
  doi: 10.1080/15384047.2016.1145850
  contributor:
    fullname: Borczuk
– volume: 12
  year: 2017
  ident: B28
  article-title: BAP1 Is Altered by Copy Number Loss, Mutation, and/or Loss of Protein Expression in More Than 70% of Malignant Peritoneal Mesotheliomas
  publication-title: J Thorac Oncol
  doi: 10.1016/j.jtho.2016.12.019
  contributor:
    fullname: Leblay
– volume: 47
  start-page: 36
  year: 2021
  ident: B6
  article-title: Peritoneal Mesothelioma: PSOGI/EURACAN Clinical Practice Guidelines for Diagnosis, Treatment and Follow-Up
  publication-title: Eur J Surg Oncol
  doi: 10.1016/j.ejso.2020.02.011
  contributor:
    fullname: Kusamura
– volume: 27
  year: 2012
  ident: B22
  article-title: Patients With Peritoneal Mesothelioma Lack Epidermal Growth Factor Receptor Tyrosine Kinase Mutations That Would Make Them Sensitive to Tyrosine Kinase Inhibitors
  publication-title: Oncol Rep
  doi: 10.3892/or.2012.1725
  contributor:
    fullname: Kalra
– volume: 33
  year: 2020
  ident: B36
  article-title: Fluorescence in Situ Hybridization (FISH) Provides Estimates of Minute and Interstitial BAP1, CDKN2A, and NF2 Gene Deletions in Peritoneal Mesothelioma
  publication-title: Mod Pathol
  doi: 10.1038/s41379-019-0371-0
  contributor:
    fullname: Brich
– volume: 51
  year: 1994
  ident: B8
  article-title: Malignant Mesothelioma: Attributable Risk of Asbestos Exposure
  publication-title: Occup Environ Med
  doi: 10.1136/oem.51.12.804
  contributor:
    fullname: Spirtas
– volume: 41
  year: 2017
  ident: B26
  article-title: A Subset of Malignant Mesotheliomas in Young Adults Are Associated With Recurrent EWSR1/FUS-ATF1 Fusions
  publication-title: Am J Surg Pathol
  doi: 10.1097/PAS.0000000000000864
  contributor:
    fullname: Desmeules
– year: 2020
  ident: B64
  article-title: Safety and Efficacy of Tazemetostat, an Enhancer of Zeste-Homolog 2 Inhibitor, in Patients With Relapsed or Refractory Malignant Mesothelioma
  publication-title: J Clin Onc
  doi: 10.1200/JCO.2020.38.15_suppl.9058
  contributor:
    fullname: Glass Zauderer
– volume: 36
  year: 2016
  ident: B25
  article-title: Genome-Based Mutational Analysis by Next Generation Sequencing in Patients With Malignant Pleural and Peritoneal Mesothelioma
  publication-title: Anticancer Res
  contributor:
    fullname: Ugurluer
– volume: 11
  year: 2021
  ident: B60
  article-title: P14/ARF-Positive Malignant Pleural Mesothelioma: A Phenotype With Distinct Immune Microenvironment
  publication-title: Front Oncol
  doi: 10.3389/fonc.2021.653497
  contributor:
    fullname: Pezzuto
– volume: 137
  year: 2013
  ident: B5
  article-title: Guidelines for Pathologic Diagnosis of Malignant Mesothelioma: 2012 Update of the Consensus Statement From the International Mesothelioma Interest Group
  publication-title: Arch Pathol Lab Med
  doi: 10.5858/arpa.2012-0214-OA
  contributor:
    fullname: Husain
– start-page: 17
  year: 2021
  ident: B17
  article-title: Asbestos and Mesothelioma: What Is Recent Advance in Research on Asbestos-Induced Molecular Carcinogenesis
  publication-title: Malignant Pleural Mesothelioma. Advances in Pathogenesis, Diagnosis, and Treatments
  doi: 10.1007/978-981-15-9158-7_2
  contributor:
    fullname: Jaurand
– volume: 13
  start-page: 122
  year: 2015
  ident: B23
  article-title: BAP1 Mutation is a Frequent Somatic Event in Peritoneal Malignant Mesothelioma
  publication-title: J Transl Med
  doi: 10.1186/s12967-015-0485-1
  contributor:
    fullname: Alakus
– volume: 12
  year: 1908
  ident: B1
  article-title: A Malignant Tumour Arising From the Endothelium of the Peritoneum, and Producing a Mucoid Ascitic Fluid
  publication-title: J Pathol Bacter
  doi: 10.1002/path.1700120212
  contributor:
    fullname: Miller
– volume: 29
  start-page: 14
  year: 2016
  ident: B55
  article-title: The Prognostic Significance of BAP1, NF2, and CDKN2A in Malignant Peritoneal Mesothelioma
  publication-title: Mod Pathol
  doi: 10.1038/modpathol.2015.121
  contributor:
    fullname: Singhi
– volume: 33
  year: 2012
  ident: B39
  article-title: Characterization of DNA Hypermethylation in Two Cases of Peritoneal Mesothelioma
  publication-title: Tumour Biol
  doi: 10.1007/s13277-012-0462-8
  contributor:
    fullname: Hama
– volume: 83
  start-page: 199
  year: 2019
  ident: B49
  article-title: Primary Peritoneal Epithelioid Mesothelioma of Clear Cell Type With a Novel VHL Gene Mutation: A Case Report
  publication-title: Hum Pathol
  doi: 10.1016/j.humpath.2018.07.033
  contributor:
    fullname: Smith-Hannah
– volume: 40
  year: 2016
  ident: B11
  article-title: Asbestos Content of Lung Tissue in Patients With Malignant Peritoneal Mesothelioma: A Study of 42 Cases
  publication-title: Ultrastruct Pathol
  doi: 10.3109/01913123.2016.1170085
  contributor:
    fullname: de Ridder
– volume: 31
  year: 2012
  ident: B66
  article-title: YAP Induces Malignant Mesothelioma Cell Proliferation by Upregulating Transcription of Cell Cycle-Promoting Genes
  publication-title: Oncogene
  doi: 10.1038/onc.2012.5
  contributor:
    fullname: Mizuno
– volume: 33
  year: 2020
  ident: B38
  article-title: Molecular Characterization of Diffuse Malignant Peritoneal Mesothelioma
  publication-title: Mod Pathol
  doi: 10.1038/s41379-020-0588-y
  contributor:
    fullname: Hung
– volume: 124
  year: 2021
  ident: B62
  article-title: Heterogeneity in PD-L1 Expression in Malignant Peritoneal Mesothelioma With Systemic or Intraperitoneal Chemotherapy
  publication-title: Br J Cancer
  doi: 10.1038/s41416-020-01130-x
  contributor:
    fullname: White
– volume: 39
  year: 2019
  ident: B34
  article-title: Splicing Modulation as Novel Therapeutic Strategy Against Diffuse Malignant Peritoneal Mesothelioma
  publication-title: EBioMed
  doi: 10.1016/j.ebiom.2018.12.025
  contributor:
    fullname: Sciarrillo
– volume: 30
  year: 2017
  ident: B27
  article-title: Genomic Profiling of Malignant Peritoneal Mesothelioma Reveals Recurrent Alterations in Epigenetic Regulatory Genes BAP1, SETD2, and DDX3X
  publication-title: Mod Pathol
  doi: 10.1038/modpathol.2016.188
  contributor:
    fullname: Joseph
– volume: 10
  start-page: 386
  year: 2020
  ident: B37
  article-title: Prognostic Value of Ki67 Percentage, WT-1 Expression and P16/CDKN2A Deletion in Diffuse Malignant Peritoneal Mesothelioma: A Single-Centre Cohort Study
  publication-title: Diagnostics (Basel)
  doi: 10.3390/diagnostics10060386
  contributor:
    fullname: Pezzuto
– volume: 69
  year: 2019
  ident: B2
  article-title: Mesothelioma: Scientific Clues for Prevention, Diagnosis, and Therapy [Published Correction Appears in CA Cancer J Clin. 2020 Jul;70(4):313-314]
  publication-title: CA Cancer J Clin
  doi: 10.3322/caac.21572
  contributor:
    fullname: Carbone
– volume: 15
  start-page: 8
  year: 2015
  ident: B40
  article-title: Molecular Characteristics of Endometrial Cancer Coexisting With Peritoneal Malignant Mesothelioma in Li-Fraumeni-Like Syndrome
  publication-title: BMC Cancer
  doi: 10.1186/s12885-015-1010-x
  contributor:
    fullname: Chao
– volume: 95
  year: 2016
  ident: B43
  article-title: Whole Exome Sequencing of Independent Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, and Malignant Peritoneal Mesothelioma: A Case Report
  publication-title: Med (Baltimore)
  doi: 10.1097/MD.0000000000005447
  contributor:
    fullname: Vanni
– volume: 32
  start-page: 88
  year: 2019
  ident: B35
  article-title: Well-Differentiated Papillary Mesothelioma of the Peritoneum Is Genetically Defined by Mutually Exclusive Mutations in TRAF7 and CDC42
  publication-title: Mod Pathol
  doi: 10.1038/s41379-018-0127-2
  contributor:
    fullname: Stevers
– volume: 17
  start-page: 739
  year: 2016
  ident: B42
  article-title: A Tumor-Specific Neo-Antigen Caused by a Frameshift Mutation in BAP1 Is a Potential Personalized Biomarker in Malignant Peritoneal Mesothelioma
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms17050739
  contributor:
    fullname: Lai
– volume: 9
  year: 2016
  ident: B57
  article-title: Case Report Molecular Changes of Malignant Mesothelioma in the Testis and Their Impact on Prognosis: Analyses of Two Cases
  publication-title: Int J Clin Exp Pathol
  contributor:
    fullname: Serio
– volume: 44
  start-page: 293
  year: 2020
  ident: B3
  article-title: Malignant Diffuse Mesothelioma in Women: A Study of 354 Cases
  publication-title: Am J Surg Pathol
  doi: 10.1097/PAS.0000000000001418
  contributor:
    fullname: Pavlisko
– volume: 126
  year: 2018
  ident: B30
  article-title: Genomic Changes of Chromosomes 8p23.1 and 1q21: Novel Mutations in Malignant Mesothelioma
  publication-title: Lung Cancer
  doi: 10.1016/j.lungcan.2018.10.012
  contributor:
    fullname: Serio
– volume: 19
  start-page: e16
  year: 2021
  ident: B18
  article-title: A Network-Biology Approach for Identification of Key Genes and Pathways Involved in Malignant Peritoneal Mesothelioma
  publication-title: Genomics Inform
  doi: 10.5808/gi.21019
  contributor:
    fullname: Mahfuz
– volume: 125
  year: 2021
  ident: B70
  article-title: Biological Basis for Novel Mesothelioma Therapies
  publication-title: Br J Cancer
  doi: 10.1038/s41416-021-01462-2
  contributor:
    fullname: Obacz
– volume: 9
  start-page: 593
  year: 2021
  ident: B63
  article-title: Rucaparib in Patients With BAP1-Deficient or BRCA1-Deficient Mesothelioma (MiST1): An Open-Label, Single-Arm, Phase 2a Clinical Trial
  publication-title: Lancet Respir Med
  doi: 10.1016/S2213-2600(20)30390-8
  contributor:
    fullname: Fennell
– volume: 4
  year: 2018
  ident: B29
  article-title: Identification of ALK Rearrangements in Malignant Peritoneal Mesothelioma
  publication-title: JAMA Oncol
  doi: 10.1001/jamaoncol.2017.2918
  contributor:
    fullname: Hung
– volume: 7
  year: 2016
  ident: B24
  article-title: Epithelioid Peritoneal Mesothelioma: A Hybrid Phenotype Within a Mesenchymal-Epithelial/Epithelial-Mesenchymal Transition Framework
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.12262
  contributor:
    fullname: Bozzi
– volume: 18
  start-page: 1818
  year: 2017
  ident: B45
  article-title: Peritoneal Mesothelioma With Residential Asbestos Exposure. Report of a Case With Long Survival (Seventeen Years) Analyzed by Cgh-Array
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms18081818
  contributor:
    fullname: Serio
– volume: 10
  year: 2015
  ident: B41
  article-title: Personalized Oncogenomics: Clinical Experience With Malignant Peritoneal Mesothelioma Using Whole Genome Sequencing
  publication-title: PloS One
  doi: 10.1371/journal.pone.0119689
  contributor:
    fullname: Sheffield
– volume: 13
  start-page: 2278
  year: 2021
  ident: B12
  article-title: Primary Ovarian Mesothelioma: A Case Series With Electron Microscopy Examination and Review of the Literature
  publication-title: Cancers (Basel)
  doi: 10.3390/cancers13092278
  contributor:
    fullname: Vimercati
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Snippet Mesothelioma is a rare malignant neoplasm with poor survival. It mainly affects the pleura (90%) but can arise in all serous cavities: peritoneum (5-10%),...
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SubjectTerms asbestos
malignant mesothelioma
molecular pathways
Oncology
peritoneal mesothelioma
prognostic factors
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Title Molecular Pathways in Peritoneal Mesothelioma: A Minireview of New Insights
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Volume 12
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