Synthesis, Characterization, and Antibacterial Activities of Novel Sulfonamides Derived through Condensation of Amino Group Containing Drugs, Amino Acids, and Their Analogs

• Published in: BioMed research international Vol. 2015; no. 2015; pp. 1 - 7
• Main Authors: Abdul Qadir, Muhammad, Iqbal, Muhammad, Ahmed, Mahmood
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2015; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Amines - chemistry; Amino acids; Amino Acids - chemistry; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Bacteria; Bacteria - drug effects; Chemical properties; Chemistry; Colleges & universities; Condensation; Drugs; E coli; Escherichia coli; Health aspects; Klebsiella pneumoniae; Membrane filters; Microbial Sensitivity Tests; Pharmaceutical Preparations - chemistry; Physiological aspects; Properties; Staphylococcus aureus; Sulfonamides; Sulfonamides - chemical synthesis; Sulfonamides - chemistry; Sulfonamides - pharmacology; Lahore Pakistan
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2015/938486

Novel sulfonamides were developed and structures of the new products were confirmed by elemental and spectral analysis (FT-IR, ESI-MS, 1HNMR, and 13CNMR). In vitro, developed compounds were screened for their antibacterial activities against medically important gram (+) and gram (−) bacterial strains, namely, S. aureus, B. subtilis, E. coli, and K. pneumoniae. The antibacterial activities have been determined by measuring MIC values (μg/mL) and zone of inhibitions (mm). Among the tested compounds, it was found that compounds 5a and 9a have most potent activity against E. coli with zone of inhibition: 31±0.12 mm (MIC: 7.81 μg/mL) and 30±0.12 mm (MIC: 7.81 μg/mL), respectively, nearly as active as ciprofloxacin (zone of inhibition: 32±0.12 mm). In contrast, all the compounds were totally inactive against the gram (+) B. subtilis.