Synaptic gene dysregulation within hippocampal CA1 pyramidal neurons in mild cognitive impairment

• Published in: Neuropharmacology Vol. 79; pp. 172 - 179
• Main Authors: Counts, Scott E., Alldred, Melissa J., Che, Shaoli, Ginsberg, Stephen D., Mufson, Elliott J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2014
• Subjects: Aged, 80 and over; Alzheimer Disease - metabolism; Alzheimer's disease; CA1 Region, Hippocampal - metabolism; Cognitive Dysfunction - metabolism; Female; Gene Expression; Gene regulation; Hippocampus; Humans; Male; Microarray; Mild cognitive impairment; Polymerase Chain Reaction; Pyramidal Cells - metabolism; Severity of Illness Index; Synaptic; Tissue Array Analysis; Synaptic; Microarray; Mild cognitive impairment; Alzheimer's disease; Gene regulation; Hippocampus
• ISSN: 0028-3908; 1873-7064; 1873-7064
• DOI: 10.1016/j.neuropharm.2013.10.018

Clinical neuropathologic studies suggest that the selective vulnerability of hippocampal CA1 pyramidal projection neurons plays a key role in the onset of cognitive impairment during the early phases of Alzheimer's disease (AD). Disruption of this neuronal population likely affects hippocampal...