Efficacy of Minocycline in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of Rodent and Clinical Studies
This study aimed to assess the efficacy of minocycline for the treatment of acute ischemic stroke. While there have been meta-analysis that surveyed the efficacy of minocycline in the treatment of acute stroke, they have some methodological limitations. We performed a new systematic review which was...
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| Published in | Frontiers in neurology Vol. 9; p. 1103 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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20.12.2018
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| Abstract | This study aimed to assess the efficacy of minocycline for the treatment of acute ischemic stroke.
While there have been meta-analysis that surveyed the efficacy of minocycline in the treatment of acute stroke, they have some methodological limitations. We performed a new systematic review which was distinct from previous one by adding new outcomes and including new studies.
Document retrieval was executed through PubMed, Cochrane Central Register of Controlled Trials, the Stroke Center, NIH's Clinical Trials, Current Controlled Trials, and the WHO International Clinical Trials Registry Platform Search Portal before Jan 2018. The data meeting the inclusion criteria were extracted. Before meta-analysis, publication bias and heterogeneity of included studies were surveyed. Random and fixed-effects models were employed to calculate pooled estimates and 95% confidence intervals (CIs). Additionally, sensitivity and subgroup analyses were implemented.
For clinical studies, 4 trials with 201 patients in the minocycline group, and 195 patients in the control group met the inclusion criteria; 3 were randomized trials. At the end of 90-day follow up or discharge day, results showed that the groups receiving minocycline were superior to the control group, with significant differences in the NIHSS scores (mean difference [MD], -2.75; 95% CI, -4.78, 0.27;
= 0.03) and mRS scores (MD, -0.98; 95% CI, -1.27, -0.69;
< 0.01), but not Barthel Index Score (MD, 9.04; 95% CI, -0.78, 18.07;
= 0.07). For rodent experiments, 14 studies were included. Neurological severity scores (NSS) was significantly improved (MD, -1.38; 95% CI, -1.64, -1.31;
< 0.01) and infarct volume was obviously reduced (Std mean difference [SMD], -2.38; 95% CI, -3.40, -1.36;
< 0.01) in the minocycline group. Heterogeneity among the studies was proved to exist for infarct volume (Chi
= 116.12,
< 0.01; I
= 0.89) but not for other variables.
Based on the results in our study, minocycline appears as an effective therapeutic option for acute ischemic stroke. |
|---|---|
| AbstractList | Objectives: This study aimed to assess the efficacy of minocycline for the treatment of acute ischemic stroke.Background: While there have been meta-analysis that surveyed the efficacy of minocycline in the treatment of acute stroke, they have some methodological limitations. We performed a new systematic review which was distinct from previous one by adding new outcomes and including new studies.Methods: Document retrieval was executed through PubMed, Cochrane Central Register of Controlled Trials, the Stroke Center, NIH's Clinical Trials, Current Controlled Trials, and the WHO International Clinical Trials Registry Platform Search Portal before Jan 2018. The data meeting the inclusion criteria were extracted. Before meta-analysis, publication bias and heterogeneity of included studies were surveyed. Random and fixed-effects models were employed to calculate pooled estimates and 95% confidence intervals (CIs). Additionally, sensitivity and subgroup analyses were implemented.Result: For clinical studies, 4 trials with 201 patients in the minocycline group, and 195 patients in the control group met the inclusion criteria; 3 were randomized trials. At the end of 90-day follow up or discharge day, results showed that the groups receiving minocycline were superior to the control group, with significant differences in the NIHSS scores (mean difference [MD], −2.75; 95% CI, −4.78, 0.27; p = 0.03) and mRS scores (MD, −0.98; 95% CI, −1.27, −0.69; p < 0.01), but not Barthel Index Score (MD, 9.04; 95% CI, −0.78, 18.07; p = 0.07). For rodent experiments, 14 studies were included. Neurological severity scores (NSS) was significantly improved (MD, −1.38; 95% CI, −1.64, −1.31; p < 0.01) and infarct volume was obviously reduced (Std mean difference [SMD], −2.38; 95% CI, −3.40, −1.36; p < 0.01) in the minocycline group. Heterogeneity among the studies was proved to exist for infarct volume (Chi2 = 116.12, p < 0.01; I2 = 0.89) but not for other variables.Conclusions: Based on the results in our study, minocycline appears as an effective therapeutic option for acute ischemic stroke. This study aimed to assess the efficacy of minocycline for the treatment of acute ischemic stroke. While there have been meta-analysis that surveyed the efficacy of minocycline in the treatment of acute stroke, they have some methodological limitations. We performed a new systematic review which was distinct from previous one by adding new outcomes and including new studies. Document retrieval was executed through PubMed, Cochrane Central Register of Controlled Trials, the Stroke Center, NIH's Clinical Trials, Current Controlled Trials, and the WHO International Clinical Trials Registry Platform Search Portal before Jan 2018. The data meeting the inclusion criteria were extracted. Before meta-analysis, publication bias and heterogeneity of included studies were surveyed. Random and fixed-effects models were employed to calculate pooled estimates and 95% confidence intervals (CIs). Additionally, sensitivity and subgroup analyses were implemented. For clinical studies, 4 trials with 201 patients in the minocycline group, and 195 patients in the control group met the inclusion criteria; 3 were randomized trials. At the end of 90-day follow up or discharge day, results showed that the groups receiving minocycline were superior to the control group, with significant differences in the NIHSS scores (mean difference [MD], -2.75; 95% CI, -4.78, 0.27; = 0.03) and mRS scores (MD, -0.98; 95% CI, -1.27, -0.69; < 0.01), but not Barthel Index Score (MD, 9.04; 95% CI, -0.78, 18.07; = 0.07). For rodent experiments, 14 studies were included. Neurological severity scores (NSS) was significantly improved (MD, -1.38; 95% CI, -1.64, -1.31; < 0.01) and infarct volume was obviously reduced (Std mean difference [SMD], -2.38; 95% CI, -3.40, -1.36; < 0.01) in the minocycline group. Heterogeneity among the studies was proved to exist for infarct volume (Chi = 116.12, < 0.01; I = 0.89) but not for other variables. Based on the results in our study, minocycline appears as an effective therapeutic option for acute ischemic stroke. Objectives: This study aimed to assess the efficacy of minocycline for the treatment of acute ischemic stroke. Background: While there have been meta-analysis that surveyed the efficacy of minocycline in the treatment of acute stroke, they have some methodological limitations. We performed a new systematic review which was distinct from previous one by adding new outcomes and including new studies. Methods: Document retrieval was executed through PubMed, Cochrane Central Register of Controlled Trials, the Stroke Center, NIH's Clinical Trials, Current Controlled Trials, and the WHO International Clinical Trials Registry Platform Search Portal before Jan 2018. The data meeting the inclusion criteria were extracted. Before meta-analysis, publication bias and heterogeneity of included studies were surveyed. Random and fixed-effects models were employed to calculate pooled estimates and 95% confidence intervals (CIs). Additionally, sensitivity and subgroup analyses were implemented. Result: For clinical studies, 4 trials with 201 patients in the minocycline group, and 195 patients in the control group met the inclusion criteria; 3 were randomized trials. At the end of 90-day follow up or discharge day, results showed that the groups receiving minocycline were superior to the control group, with significant differences in the NIHSS scores (mean difference [MD], −2.75; 95% CI, −4.78, 0.27; p = 0.03) and mRS scores (MD, −0.98; 95% CI, −1.27, −0.69; p < 0.01), but not Barthel Index Score (MD, 9.04; 95% CI, −0.78, 18.07; p = 0.07). For rodent experiments, 14 studies were included. Neurological severity scores (NSS) was significantly improved (MD, −1.38; 95% CI, −1.64, −1.31; p < 0.01) and infarct volume was obviously reduced (Std mean difference [SMD], −2.38; 95% CI, −3.40, −1.36; p < 0.01) in the minocycline group. Heterogeneity among the studies was proved to exist for infarct volume (Chi 2 = 116.12, p < 0.01; I 2 = 0.89) but not for other variables. Conclusions: Based on the results in our study, minocycline appears as an effective therapeutic option for acute ischemic stroke. |
| Author | Zhang, Xin Xia, Bin Zheng, Wei Sheng, Zhaofu Li, Hongmin Yong, V Wee Liu, Yang Xue, Mengzhou |
| AuthorAffiliation | 2 The Henan Medical Key Laboratory of Translational Cerebrovascular Diseases , Zhengzhou , China 3 Hotchkiss Brain Institute, University of Calgary , Calgary, AB , Canada 4 Department of Clinical Neurosciences, University of Calgary , Calgary, AB , Canada 1 The Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University , Zhengzhou , China |
| AuthorAffiliation_xml | – name: 4 Department of Clinical Neurosciences, University of Calgary , Calgary, AB , Canada – name: 1 The Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University , Zhengzhou , China – name: 2 The Henan Medical Key Laboratory of Translational Cerebrovascular Diseases , Zhengzhou , China – name: 3 Hotchkiss Brain Institute, University of Calgary , Calgary, AB , Canada |
| Author_xml | – sequence: 1 givenname: Zhaofu surname: Sheng fullname: Sheng, Zhaofu organization: The Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China – sequence: 2 givenname: Yang surname: Liu fullname: Liu, Yang organization: The Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China – sequence: 3 givenname: Hongmin surname: Li fullname: Li, Hongmin organization: The Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China – sequence: 4 givenname: Wei surname: Zheng fullname: Zheng, Wei organization: The Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China – sequence: 5 givenname: Bin surname: Xia fullname: Xia, Bin organization: The Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China – sequence: 6 givenname: Xin surname: Zhang fullname: Zhang, Xin organization: The Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China – sequence: 7 givenname: V Wee surname: Yong fullname: Yong, V Wee organization: Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada – sequence: 8 givenname: Mengzhou surname: Xue fullname: Xue, Mengzhou organization: The Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30619060$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | Copyright © 2018 Sheng, Liu, Li, Zheng, Xia, Zhang, Yong and Xue. 2018 Sheng, Liu, Li, Zheng, Xia, Zhang, Yong and Xue |
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| Keywords | clinical study meta-analysis rodent study minocycline ischemic stroke |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Konark Malhotra, Charleston Area Medical Center, United States; Adam Denes, Institute of Experimental Medicine (MTA), Hungary Edited by: Heike Wulff, University of California, Davis, United States This article was submitted to Stroke, a section of the journal Frontiers in Neurology |
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While there have been meta-analysis that surveyed the... Objectives: This study aimed to assess the efficacy of minocycline for the treatment of acute ischemic stroke. Background: While there have been meta-analysis... Objectives: This study aimed to assess the efficacy of minocycline for the treatment of acute ischemic stroke.Background: While there have been meta-analysis... |
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| Title | Efficacy of Minocycline in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of Rodent and Clinical Studies |
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