Evidence of Augmented Intrarenal Angiotensinogen Associated With Glomerular Swelling in Gestational Hypertension and Preeclampsia: Clinical Implications

• Published in: Journal of the American Heart Association Vol. 8; no. 13; p. e012611
• Main Authors: Mistry, Hiten D, Kurlak, Lesia O, Gardner, David S, Torffvit, Ole, Hansen, Alastair, Broughton Pipkin, Fiona, Strevens, Helena
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 02.07.2019; Wiley
• Subjects: Adult; angiotensinogen; Angiotensinogen - metabolism; Angiotensinogen - urine; Biopsy; Case-Control Studies; Clinical Medicine; Edema - pathology; Female; glomerular; Humans; hypertension; Hypertension, Pregnancy-Induced - metabolism; Hypertension, Pregnancy-Induced - pathology; Immunohistochemistry; kidney; Kidney Glomerulus - metabolism; Kidney Glomerulus - pathology; Kidney Tubules, Proximal - metabolism; Kidney Tubules, Proximal - pathology; Klinisk medicin; Medical and Health Sciences; Medicin och hälsovetenskap; Obstetrics, Gynecology and Reproductive Medicine; Original Research; Potassium - urine; Pre-Eclampsia - metabolism; Pre-Eclampsia - pathology; Pregnancy; Renin-Angiotensin System; Reproduktionsmedicin och gynekologi; Sodium - urine; urine; kidney; glomerular; urine; angiotensinogen; hypertension; pregnancy

Background AGT (angiotensinogen) synthesis occurs in renal proximal tubular epithelial cells, independent from systemic AGT , as a component of the intrarenal renin-angiotensin system. We investigated urinary AGT , as a biomarker for renin-angiotensin system activation, and electrolyte concentration...