Fecal Metabolomics and Potential Biomarkers for Systemic Lupus Erythematosus

The role of metabolomics in autoimmune diseases has been a rapidly expanding area in researches over the last decade, while its pathophysiologic impact on systemic lupus erythematosus (SLE) remains poorly elucidated. In this study, we analyzed the metabolic profiling of fecal samples from SLE patien...

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Published inFrontiers in immunology Vol. 10; p. 976
Main Authors Zhang, Qiong, Yin, Xiaofeng, Wang, Haifang, Wu, Xing, Li, Xin, Li, Yao, Zhang, Xiaohe, Fu, Chen, Li, Haixia, Qiu, Yurong
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 03.05.2019
Subjects
biomarker
feces
Immunology
liquid chromatography
mass spectrometry
metabolomics
systemic lupus erythematosus
liquid chromatography
mass spectrometry
systemic lupus erythematosus
biomarker
metabolomics
feces
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Summary:The role of metabolomics in autoimmune diseases has been a rapidly expanding area in researches over the last decade, while its pathophysiologic impact on systemic lupus erythematosus (SLE) remains poorly elucidated. In this study, we analyzed the metabolic profiling of fecal samples from SLE patients and healthy controls based on ultra-high-performance liquid chromatography equipped with mass spectrometry for exploring the potential biomarkers of SLE. The results showed that 23 differential metabolites and 5 perturbed pathways were identified between the two groups, including aminoacyl-tRNA biosynthesis, thiamine metabolism, nitrogen metabolism, tryptophan metabolism, and cyanoamino acid metabolism. In addition, logistic regression and ROC analysis were used to establish a diagnostic model for distinguishing SLE patients from healthy controls. The combined model of fecal PG 27:2 and proline achieved an area under the ROC curve of 0.846, and had a good diagnostic efficacy. In the present study, we analyzed the correlations between fecal metabolic perturbations and SLE pathogenesis. In summary, we firstly illustrate the comprehensive metabolic profiles of feces in SLE patients, suggesting that the fecal metabolites could be used as the potential non-invasive biomarkers for SLE.
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Reviewed by: Jillian M. Richmond, University of Massachusetts Medical School, United States; Andras Perl, Upstate Medical University, United States
These authors have contributed equally to this work
Edited by: Rolando Cimaz, University of Florence, Italy
This article was submitted to Autoimmune and Autoinflammatory Disorders, a section of the journal Frontiers in Immunology
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.00976