Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells

• Published in: The Journal of immunology (1950) Vol. 188; no. 11; pp. 5682 - 5693
• Main Authors: Benoit, Marie E, Clarke, Elizabeth V, Morgado, Pedro, Fraser, Deborah A, Tenner, Andrea J
• Format: Journal Article
• Language: English
• Published: United States 01.06.2012
• Subjects: Apoptosis Regulatory Proteins - physiology; Caspase 1 - metabolism; Caspase Inhibitors; Cell Adhesion - immunology; Cell Polarity - immunology; Cells, Cultured; Chemokines - biosynthesis; Complement C1q - physiology; Cytokines - biosynthesis; Humans; Inflammasomes - antagonists & inhibitors; Inflammasomes - immunology; Interleukin-1beta - metabolism; Lipopolysaccharides - metabolism; Lymphocytes - cytology; Lymphocytes - immunology; Macrophages - cytology; Macrophages - immunology; Macrophages - metabolism

Deficiency in C1q, the recognition component of the classical complement cascade and a pattern recognition receptor involved in apoptotic cell clearance, leads to lupus-like autoimmune diseases characterized by auto-antibodies to self proteins and aberrant innate immune cell activation likely due to...