Circulating Microparticles in Children With Sickle Cell Anemia in a Tertiary Center in Upper Egypt
Sickle cell disease (SCD) is a genetically inherited hemolytic anemia increasingly appreciated as a chronic inflammatory condition and hypercoagulable state with high thrombotic risk. It is associated with disturbed immune phenotype and function and circulating microparticles (MPs) derived from mult...
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| Published in | Clinical and applied thrombosis/hemostasis Vol. 25; p. 1076029619828839 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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SAGE Publications
01.01.2019
SAGE PUBLICATIONS, INC SAGE Publishing |
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| Abstract | Sickle cell disease (SCD) is a genetically inherited hemolytic anemia increasingly appreciated as a chronic inflammatory condition and hypercoagulable state with high thrombotic risk. It is associated with disturbed immune phenotype and function and circulating microparticles (MPs) derived from multiple cell sources. This study was carried out to determine MPs profiles in patients with sickle cell anemia (either on hydroxyurea (HU) therapy or those with no disease-modifying therapy) and to compare these profiles with healthy children. Moreover, our study assesses the potential impact of HU on other aspects of circulating MPs. We performed a cross-sectional study on 30 pediatric patients with SCD divided by treatment into 2 groups (those receiving HU or no therapy) attending Hematology Clinic and 20 age-matched healthy children. The blood samples obtained were analyzed for MPs by flow cytometry. Sickle cell disease group with no therapy showed elevated levels of total, platelet, and erythroid MPs. In contrast, therapy with HU was associated with normalization of MPs. This study provided additional evidence that HU is an effective treatment option in pediatric patients with SCD, as it seems that it decreases the abnormally elevated MPs in those patients. |
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| AbstractList | Sickle cell disease (SCD) is a genetically inherited hemolytic anemia increasingly appreciated as a chronic inflammatory condition and hypercoagulable state with high thrombotic risk. It is associated with disturbed immune phenotype and function and circulating microparticles (MPs) derived from multiple cell sources. This study was carried out to determine MPs profiles in patients with sickle cell anemia (either on hydroxyurea (HU) therapy or those with no disease-modifying therapy) and to compare these profiles with healthy children. Moreover, our study assesses the potential impact of HU on other aspects of circulating MPs. We performed a cross-sectional study on 30 pediatric patients with SCD divided by treatment into 2 groups (those receiving HU or no therapy) attending Hematology Clinic and 20 age-matched healthy children. The blood samples obtained were analyzed for MPs by flow cytometry. Sickle cell disease group with no therapy showed elevated levels of total, platelet, and erythroid MPs. In contrast, therapy with HU was associated with normalization of MPs. This study provided additional evidence that HU is an effective treatment option in pediatric patients with SCD, as it seems that it decreases the abnormally elevated MPs in those patients. |
| Author | Galal, Shereen M. Saad, Khaled Hetta, Helal F. Sror, Shaban M. Zahran, Asmaa M. Elhoufey, Amira Embaby, Mostafa M. Aboul-Khair, Mohamed Diab Alblihed, Mohamd A. Elsayh, Khalid I. Youssef, Mervat A. M. Abdel-Raheem, Yasser F. |
| AuthorAffiliation | 3 Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt 6 Department of Community Health Nursing, Faculty of Nursing, Assiut University, Assiut, Egypt 5 Department of Medical Biochemistry, School of Medicine Taif University Taif Saudi Arabia, Taif, Saudi Arabia 7 Department of Community Health Nursing, Sabia University College, Jazan University, Kingdom of Saudi Arabia 2 Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt 1 Department of Clinical Pathology, South Egypt Cancer Institute, Assiut, Egypt 4 Department of Pediatrics, Faculty of Medicine, Al-Azhar University, Cairo, Egypt |
| AuthorAffiliation_xml | – name: 2 Department of Pediatrics, Faculty of Medicine, Assiut University, Assiut, Egypt – name: 6 Department of Community Health Nursing, Faculty of Nursing, Assiut University, Assiut, Egypt – name: 5 Department of Medical Biochemistry, School of Medicine Taif University Taif Saudi Arabia, Taif, Saudi Arabia – name: 7 Department of Community Health Nursing, Sabia University College, Jazan University, Kingdom of Saudi Arabia – name: 3 Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt – name: 4 Department of Pediatrics, Faculty of Medicine, Al-Azhar University, Cairo, Egypt – name: 1 Department of Clinical Pathology, South Egypt Cancer Institute, Assiut, Egypt |
| Author_xml | – sequence: 1 givenname: Asmaa M. surname: Zahran fullname: Zahran, Asmaa M. – sequence: 2 givenname: Khalid I. surname: Elsayh fullname: Elsayh, Khalid I. – sequence: 3 givenname: Khaled orcidid: 0000-0002-8473-6116 surname: Saad fullname: Saad, Khaled email: ksaad8@yahoo.com – sequence: 4 givenname: Mostafa M. surname: Embaby fullname: Embaby, Mostafa M. – sequence: 5 givenname: Mervat A. M. surname: Youssef fullname: Youssef, Mervat A. M. – sequence: 6 givenname: Yasser F. surname: Abdel-Raheem fullname: Abdel-Raheem, Yasser F. – sequence: 7 givenname: Shaban M. surname: Sror fullname: Sror, Shaban M. – sequence: 8 givenname: Shereen M. surname: Galal fullname: Galal, Shereen M. – sequence: 9 givenname: Helal F. orcidid: 0000-0001-8541-7304 surname: Hetta fullname: Hetta, Helal F. – sequence: 10 givenname: Mohamed Diab surname: Aboul-Khair fullname: Aboul-Khair, Mohamed Diab – sequence: 11 givenname: Mohamd A. surname: Alblihed fullname: Alblihed, Mohamd A. – sequence: 12 givenname: Amira surname: Elhoufey fullname: Elhoufey, Amira |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30740989$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1164_rccm_201807_1370OC crossref_primary_10_1038_s41390_021_01627_y crossref_primary_10_1111_ijlh_14162 crossref_primary_10_1007_s13204_021_01932_2 crossref_primary_10_1177_1076029619895111 crossref_primary_10_1038_s41390_021_01892_x crossref_primary_10_1159_000525640 |
| Cites_doi | 10.1182/blood.V88.6.1960.bloodjournal8861960 10.1111/bjh.14112 10.1111/j.1365-2141.2008.07155.x 10.1182/blood.V89.3.1078 10.1136/archdischild-2013-303773 10.1161/ATVBAHA.110.211615 10.1046/j.1365-2257.2002.t01-1-00433.x 10.1182/blood.V96.3.1119 10.1017/S1462399406010659 10.4103/0300-1652.132058 10.1542/peds.2008-0441 10.1160/TH11-10-0689 10.1186/1756-0500-5-396 10.1182/blood-2009-02-205492 10.1164/rccm.200302-224OC 10.1016/j.bcmd.2016.01.005 10.3324/haematol.2013.085779 10.1016/S0049-3848(03)00064-1 10.1002/ajh.23629 10.1016/S0140-6736(11)60355-3 10.3324/haematol.2012.073619 10.3324/haematol.2009.008938 10.1093/tropej/45.1.23 10.1002/ajh.20196 10.1002/jlb.66.3.411 10.1182/blood.V93.12.4222 10.1016/0895-4356(92)90073-V |
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| Keywords | microparticles hydroxyurea Sickle cell disease children |
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| References | Hugel, Weltin, Holl 1998; 18 Hebbel, Key 2016; 174 Vingert, Tamagne, Desmarets 2014; 89 Westerman, Pizzey, Hirschman 2008; 142 West, Wethers, Smith, Steinberg 1992; 45 Wallace, Marshall, Ramos 2009; 114 Shcherbina, Remold-O’Donnell 1999; 93 Holtzclaw, Jack, Aguayo, Eckman, Roman, Hsu 2004; 169 Lard, Mul, de Haas, Roos, Duits 1999; 66 Wun, Cordoba, Rangaswami, Cheung, Paglieroni 2002; 24 Setty, Kulkarni, Rao, Stuart 2000; 96 Falanga, Trinchero 2013; 98 Madigan, Malik 2006; 8 Zahran, Elsayh, Saad, Embaby, Ali 2016; 57 van Beers, Schaap, Berckmans 2009; 94 Ferster, Vermylen, Cornu 1996; 88 Soliman, elZalabany, Amer, Ansari 1999; 45 Gerotziafas, Van Dreden, Chaari 2012; 107 Steinberg, Lu, Barton, Terrin, Charache, Dover 1997; 89 Pathare, Al Kindi, Alnaqdy, Daar, Knox-Macaulay, Dennison 2004; 77 Falcao, Donadi 1989; 35 Nebor, Romana, Santiago 2013; 98 Jimenez, Jy, Mauro, Soderland, Horstman, Ahn 2003; 109 Overturf, Powars 1980; 40 Wang, Ware, Miller 2011; 377 Ojo, Shokunbi 2014; 55 Chakravorty, Williams 2015; 100 Akinbami, Dosunmu, Adediran, Oshinaike, Adebola, Arogundade 2012; 5 Polanowska-Grabowska, Wallace, Field 2010; 30 Strouse, Lanzkron, Beach 2008; 122 bibr16-1076029619828839 bibr29-1076029619828839 bibr11-1076029619828839 bibr3-1076029619828839 bibr24-1076029619828839 bibr2-1076029619828839 bibr25-1076029619828839 bibr7-1076029619828839 bibr12-1076029619828839 bibr20-1076029619828839 Overturf G (bibr6-1076029619828839) 1980; 40 bibr21-1076029619828839 bibr26-1076029619828839 bibr4-1076029619828839 Falcao RP (bibr5-1076029619828839) 1989; 35 bibr8-1076029619828839 bibr13-1076029619828839 bibr17-1076029619828839 bibr30-1076029619828839 bibr22-1076029619828839 bibr27-1076029619828839 bibr14-1076029619828839 bibr9-1076029619828839 bibr10-1076029619828839 bibr28-1076029619828839 bibr15-1076029619828839 bibr1-1076029619828839 bibr23-1076029619828839 Hugel B (bibr18-1076029619828839) 1998; 18 bibr19-1076029619828839 |
| References_xml | – volume: 377 start-page: 1663 issue: 9778 year: 2011 end-page: 1672 article-title: Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG) publication-title: Lancet contributor: fullname: Miller – volume: 174 start-page: 16 issue: 1 year: 2016 end-page: 29 article-title: Microparticles in sickle cell anaemia: promise and pitfalls publication-title: Br J Haematol contributor: fullname: Key – volume: 107 start-page: 1044 issue: 6 year: 2012 end-page: 1052 article-title: The acceleration of the propagation phase of thrombin generation in patients with steady-state sickle cell disease is associated with circulating erythrocyte-derived microparticles publication-title: Thromb Haemost contributor: fullname: Chaari – volume: 100 start-page: 48 issue: 1 year: 2015 end-page: 53 article-title: Sickle cell disease: a neglected chronic disease of increasing global health importance publication-title: Arch Dis Child contributor: fullname: Williams – volume: 30 start-page: 2392 issue: 12 year: 2010 end-page: 2399 article-title: P-selectin-mediated platelet-neutrophil aggregate formation activates neutrophils in mouse and human sickle cell disease publication-title: Arterioscler Thromb Vasc Biol contributor: fullname: Field – volume: 5 start-page: 396 year: 2012 article-title: Haematological values in homozygous sickle cell disease in steady state and hemoglobin phenotypes AA controls in Lagos, Nigeria publication-title: BMC Res Notes contributor: fullname: Arogundade – volume: 24 start-page: 81 issue: 2 year: 2002 end-page: 88 article-title: Activated monocytes and platelet-monocyte aggregates in patients with sickle cell disease publication-title: Clin Lab Haematol contributor: fullname: Paglieroni – volume: 8 start-page: 1 issue: 9 year: 2006 end-page: 23 article-title: Pathophysiology and therapy for hemoglobinopathies. Part I: sickle cell disease publication-title: Expert Rev Mol Med contributor: fullname: Malik – volume: 98 start-page: 862 issue: 6 year: 2013 end-page: 867 article-title: Fetal hemoglobin and hydroxycarbamide modulate both plasma concentration and cellular origin of circulating microparticles in sickle cell anemia children publication-title: Haematologica contributor: fullname: Santiago – volume: 114 start-page: 667 issue: 3 year: 2009 end-page: 676 article-title: NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines publication-title: Blood contributor: fullname: Ramos – volume: 45 start-page: 23 issue: 1 year: 1999 end-page: 30 article-title: Growth and pubertal development in transfusion-dependent children and adolescents with thalassaemia major and sickle cell disease: a comparative study publication-title: J Trop Pediatr contributor: fullname: Ansari – volume: 55 start-page: 242 issue: 3 year: 2014 end-page: 245 article-title: CD4+ T lymphocytes count in sickle cell anaemia patients attending a tertiary hospital publication-title: Niger Med J contributor: fullname: Shokunbi – volume: 88 start-page: 1960 issue: 6 year: 1996 end-page: 1964 article-title: Hydroxyurea for treatment of severe sickle cell anemia: a pediatric clinical trial publication-title: Blood contributor: fullname: Cornu – volume: 89 start-page: 261 issue: 3 year: 2014 end-page: 266 article-title: Partial dysfunction of Treg activation in sickle cell disease publication-title: Am J Hematol contributor: fullname: Desmarets – volume: 35 start-page: 70 issue: 2 year: 1989 end-page: 74 article-title: Infection and immunity in sickle cell disease publication-title: AMB Rev Assoc Med Bras contributor: fullname: Donadi – volume: 57 start-page: 91 year: 2016 end-page: 96 article-title: Regulatory B cells (CD19+ CD38hiCD24hi) in alloimmunized and non-alloimmunized children with β-thalassemia major publication-title: Blood Cells Mol Dis contributor: fullname: Ali – volume: 77 start-page: 323 issue: 4 year: 2004 end-page: 328 article-title: Cytokine profile of sickle cell disease in Oman publication-title: Am J Hematol contributor: fullname: Dennison – volume: 98 start-page: 995 issue: 7 year: 2013 end-page: 997 article-title: Circulating microparticles in children with sickle cell anemia: a heterogeneous procoagulant storm directed by hemolysis and fetal hemoglobin publication-title: Haematologica contributor: fullname: Trinchero – volume: 93 start-page: 4222 issue: 12 year: 1999 end-page: 4231 article-title: Role of caspase in a subset of human platelet activation responses publication-title: Blood contributor: fullname: Remold-O’Donnell – volume: 89 start-page: 1078 issue: 3 year: 1997 end-page: 1088 article-title: Fetal hemoglobin in sickle cell anemia: determinants of response to hydroxyurea. Multicenter Study of Hydroxyurea publication-title: Blood contributor: fullname: Dover – volume: 66 start-page: 411 issue: 3 year: 1999 end-page: 415 article-title: Neutrophil activation in sickle cell disease publication-title: J Leukoc Biol contributor: fullname: Duits – volume: 122 start-page: 1332 issue: 6 year: 2008 end-page: 1342 article-title: Hydroxyurea for sickle cell disease: a systematic review for efficacy and toxicity in children publication-title: Pediatrics contributor: fullname: Beach – volume: 40 start-page: 283 year: 1980 end-page: 292 article-title: Infections in sickle cell anemia: pathogenesis and control publication-title: Tex Rep Biol Med contributor: fullname: Powars – volume: 142 start-page: 126 issue: 1 year: 2008 end-page: 135 article-title: Microvesicles in hemoglobinopathies offer insights into mechanisms of hypercoagulability, haemolysis and the effects of therapy publication-title: Br J Haematol contributor: fullname: Hirschman – volume: 169 start-page: 687 issue: 6 year: 2004 end-page: 695 article-title: Enhanced pulmonary and systemic response to endotoxin in transgenic sickle mice publication-title: Am J Respir Crit Care Med contributor: fullname: Hsu – volume: 18 start-page: 3289 issue: 5A year: 1998 end-page: 3294 article-title: Assessment of apoptosis occurring in spleen cells from nitrogen mustard-treated or gamma-irradiated mice publication-title: Anticancer Res contributor: fullname: Holl – volume: 45 start-page: 893 issue: 8 year: 1992 end-page: 909 article-title: Laboratory profile of sickle cell disease: a cross-sectional analysis. The Cooperative Study of Sickle Cell Disease publication-title: J Clin Epidemiol contributor: fullname: Steinberg – volume: 96 start-page: 1119 issue: 3 year: 2000 end-page: 1124 article-title: Fetal hemoglobin in sickle cell disease: relationship to erythrocyte phosphatidylserine exposure and coagulation activation publication-title: Blood contributor: fullname: Stuart – volume: 94 start-page: 1513 issue: 11 year: 2009 end-page: 1519 article-title: Circulating erythrocyte-derived microparticles are associated with coagulation activation in sickle cell disease publication-title: Haematologica contributor: fullname: Berckmans – volume: 109 start-page: 175 issue: 4 year: 2003 end-page: 180 article-title: Endothelial cells release phenotypically and quantitatively distinct microparticles inactivation and apoptosis publication-title: Thromb Res contributor: fullname: Ahn – ident: bibr13-1076029619828839 doi: 10.1182/blood.V88.6.1960.bloodjournal8861960 – ident: bibr19-1076029619828839 doi: 10.1111/bjh.14112 – ident: bibr27-1076029619828839 doi: 10.1111/j.1365-2141.2008.07155.x – ident: bibr23-1076029619828839 doi: 10.1182/blood.V89.3.1078 – ident: bibr1-1076029619828839 doi: 10.1136/archdischild-2013-303773 – ident: bibr21-1076029619828839 doi: 10.1161/ATVBAHA.110.211615 – volume: 40 start-page: 283 year: 1980 ident: bibr6-1076029619828839 publication-title: Tex Rep Biol Med contributor: fullname: Overturf G – ident: bibr10-1076029619828839 doi: 10.1046/j.1365-2257.2002.t01-1-00433.x – ident: bibr28-1076029619828839 doi: 10.1182/blood.V96.3.1119 – ident: bibr4-1076029619828839 doi: 10.1017/S1462399406010659 – ident: bibr7-1076029619828839 doi: 10.4103/0300-1652.132058 – ident: bibr14-1076029619828839 doi: 10.1542/peds.2008-0441 – ident: bibr25-1076029619828839 doi: 10.1160/TH11-10-0689 – ident: bibr24-1076029619828839 doi: 10.1186/1756-0500-5-396 – ident: bibr12-1076029619828839 doi: 10.1182/blood-2009-02-205492 – ident: bibr8-1076029619828839 doi: 10.1164/rccm.200302-224OC – ident: bibr2-1076029619828839 doi: 10.1016/j.bcmd.2016.01.005 – volume: 18 start-page: 3289 issue: 5 year: 1998 ident: bibr18-1076029619828839 publication-title: Anticancer Res contributor: fullname: Hugel B – ident: bibr30-1076029619828839 doi: 10.3324/haematol.2013.085779 – ident: bibr16-1076029619828839 doi: 10.1016/S0049-3848(03)00064-1 – ident: bibr22-1076029619828839 doi: 10.1002/ajh.23629 – ident: bibr15-1076029619828839 doi: 10.1016/S0140-6736(11)60355-3 – ident: bibr29-1076029619828839 doi: 10.3324/haematol.2012.073619 – ident: bibr26-1076029619828839 doi: 10.3324/haematol.2009.008938 – ident: bibr3-1076029619828839 doi: 10.1093/tropej/45.1.23 – ident: bibr11-1076029619828839 doi: 10.1002/ajh.20196 – volume: 35 start-page: 70 issue: 2 year: 1989 ident: bibr5-1076029619828839 publication-title: AMB Rev Assoc Med Bras contributor: fullname: Falcao RP – ident: bibr9-1076029619828839 doi: 10.1002/jlb.66.3.411 – ident: bibr17-1076029619828839 doi: 10.1182/blood.V93.12.4222 – ident: bibr20-1076029619828839 doi: 10.1016/0895-4356(92)90073-V |
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| SubjectTerms | Original Pediatrics Sickle cell anemia Sickle cell disease |
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| Title | Circulating Microparticles in Children With Sickle Cell Anemia in a Tertiary Center in Upper Egypt |
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