A higher BMI is not associated with a different immune response and disease course in critically ill COVID-19 patients
Obesity appears to be an independent risk factor for ICU admission and a severe disease course in COVID-19 patients. An aberrant inflammatory response and impaired respiratory function have been suggested as underlying mechanisms. We investigated whether obesity is associated with differences in inf...
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Published in | International Journal of Obesity Vol. 45; no. 3; pp. 687 - 694 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Nature Publishing Group
01.03.2021
Nature Publishing Group UK |
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Abstract | Obesity appears to be an independent risk factor for ICU admission and a severe disease course in COVID-19 patients. An aberrant inflammatory response and impaired respiratory function have been suggested as underlying mechanisms. We investigated whether obesity is associated with differences in inflammatory, respiratory, and clinical outcome parameters in critically ill COVID-19 patients.
Sixty-seven COVID-19 ICU patients were divided into obese (BMI ≥ 30 kg/m
, n = 18, 72% class I obesity, 28% class II obesity) and non-obese (BMI < 30 kg/m
, n = 49) groups. Concentrations of circulating interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), interferon gamma-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, and IL-1 receptor antagonist (RA) were determined from ICU admission until 10 days afterward, and routine laboratory and clinical parameters were collected.
BMI was 32.6 [31.2-34.5] and 26.0 [24.4-27.7] kg/m
in the obese and non-obese group, respectively. Apart from temperature, which was significantly lower in obese patients (38.1 [36.9-38.9] vs. 38.7 [38.0 -39.5] °C, p = 0.02), there were no between-group differences on ICU admission. Plasma cytokine concentrations declined over time (p < 0.05 for all), but no differences between obese and non-obese patients were observed. Also, BMI did not correlate with the cytokine response (IL-6 r = 0.09, p = 0.61, TNF-α r = 0.03, p = 0.99, IP-10 r = 0.28, p = 0.11). The kinetics of clinical inflammatory parameters and respiratory mechanics were also similar in both groups. Finally, no differences in time on ventilator, ICU length of stay or 40-day mortality between obese and non-obese patients were apparent.
In COVID-19 patients requiring mechanical ventilation in the ICU, a higher BMI is not related to a different immunological response, unfavorable respiratory mechanics, or impaired outcome. |
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AbstractList | Obesity appears to be an independent risk factor for ICU admission and a severe disease course in COVID-19 patients. An aberrant inflammatory response and impaired respiratory function have been suggested as underlying mechanisms. We investigated whether obesity is associated with differences in inflammatory, respiratory, and clinical outcome parameters in critically ill COVID-19 patients.
Sixty-seven COVID-19 ICU patients were divided into obese (BMI ≥ 30 kg/m
, n = 18, 72% class I obesity, 28% class II obesity) and non-obese (BMI < 30 kg/m
, n = 49) groups. Concentrations of circulating interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), interferon gamma-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, and IL-1 receptor antagonist (RA) were determined from ICU admission until 10 days afterward, and routine laboratory and clinical parameters were collected.
BMI was 32.6 [31.2-34.5] and 26.0 [24.4-27.7] kg/m
in the obese and non-obese group, respectively. Apart from temperature, which was significantly lower in obese patients (38.1 [36.9-38.9] vs. 38.7 [38.0 -39.5] °C, p = 0.02), there were no between-group differences on ICU admission. Plasma cytokine concentrations declined over time (p < 0.05 for all), but no differences between obese and non-obese patients were observed. Also, BMI did not correlate with the cytokine response (IL-6 r = 0.09, p = 0.61, TNF-α r = 0.03, p = 0.99, IP-10 r = 0.28, p = 0.11). The kinetics of clinical inflammatory parameters and respiratory mechanics were also similar in both groups. Finally, no differences in time on ventilator, ICU length of stay or 40-day mortality between obese and non-obese patients were apparent.
In COVID-19 patients requiring mechanical ventilation in the ICU, a higher BMI is not related to a different immunological response, unfavorable respiratory mechanics, or impaired outcome. Obesity appears to be an independent risk factor for ICU admission and a severe disease course in COVID-19 patients. An aberrant inflammatory response and impaired respiratory function have been suggested as underlying mechanisms. We investigated whether obesity is associated with differences in inflammatory, respiratory, and clinical outcome parameters in critically ill COVID-19 patients. BMI was 32.6 [31.2-34.5] and 26.0 [24.4-27.7] kg/m.sup.2 in the obese and non-obese group, respectively. Apart from temperature, which was significantly lower in obese patients (38.1 [36.9-38.9] vs. 38.7 [38.0 -39.5] °C, p = 0.02), there were no between-group differences on ICU admission. Plasma cytokine concentrations declined over time (p < 0.05 for all), but no differences between obese and non-obese patients were observed. Also, BMI did not correlate with the cytokine response (IL-6 r = 0.09, p = 0.61, TNF-[alpha] r = 0.03, p = 0.99, IP-10 r = 0.28, p = 0.11). The kinetics of clinical inflammatory parameters and respiratory mechanics were also similar in both groups. Finally, no differences in time on ventilator, ICU length of stay or 40-day mortality between obese and non-obese patients were apparent. In COVID-19 patients requiring mechanical ventilation in the ICU, a higher BMI is not related to a different immunological response, unfavorable respiratory mechanics, or impaired outcome. Background/objectives Obesity appears to be an independent risk factor for ICU admission and a severe disease course in COVID-19 patients. An aberrant inflammatory response and impaired respiratory function have been suggested as underlying mechanisms. We investigated whether obesity is associated with differences in inflammatory, respiratory, and clinical outcome parameters in critically ill COVID-19 patients. Subjects/methods Sixty-seven COVID-19 ICU patients were divided into obese (BMI [greater than or equal to] 30 kg/m.sup.2, n = 18, 72% class I obesity, 28% class II obesity) and non-obese (BMI < 30 kg/m.sup.2, n = 49) groups. Concentrations of circulating interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor alpha (TNF-[alpha]), interferon gamma (IFN-[gamma]), interferon gamma-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, and IL-1 receptor antagonist (RA) were determined from ICU admission until 10 days afterward, and routine laboratory and clinical parameters were collected. Results BMI was 32.6 [31.2-34.5] and 26.0 [24.4-27.7] kg/m.sup.2 in the obese and non-obese group, respectively. Apart from temperature, which was significantly lower in obese patients (38.1 [36.9-38.9] vs. 38.7 [38.0 -39.5] °C, p = 0.02), there were no between-group differences on ICU admission. Plasma cytokine concentrations declined over time (p < 0.05 for all), but no differences between obese and non-obese patients were observed. Also, BMI did not correlate with the cytokine response (IL-6 r = 0.09, p = 0.61, TNF-[alpha] r = 0.03, p = 0.99, IP-10 r = 0.28, p = 0.11). The kinetics of clinical inflammatory parameters and respiratory mechanics were also similar in both groups. Finally, no differences in time on ventilator, ICU length of stay or 40-day mortality between obese and non-obese patients were apparent. Conclusions In COVID-19 patients requiring mechanical ventilation in the ICU, a higher BMI is not related to a different immunological response, unfavorable respiratory mechanics, or impaired outcome. BACKGROUND/OBJECTIVESObesity appears to be an independent risk factor for ICU admission and a severe disease course in COVID-19 patients. An aberrant inflammatory response and impaired respiratory function have been suggested as underlying mechanisms. We investigated whether obesity is associated with differences in inflammatory, respiratory, and clinical outcome parameters in critically ill COVID-19 patients. SUBJECTS/METHODSSixty-seven COVID-19 ICU patients were divided into obese (BMI ≥ 30 kg/m2, n = 18, 72% class I obesity, 28% class II obesity) and non-obese (BMI < 30 kg/m2, n = 49) groups. Concentrations of circulating interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), interferon gamma-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, and IL-1 receptor antagonist (RA) were determined from ICU admission until 10 days afterward, and routine laboratory and clinical parameters were collected. RESULTSBMI was 32.6 [31.2-34.5] and 26.0 [24.4-27.7] kg/m2 in the obese and non-obese group, respectively. Apart from temperature, which was significantly lower in obese patients (38.1 [36.9-38.9] vs. 38.7 [38.0 -39.5] °C, p = 0.02), there were no between-group differences on ICU admission. Plasma cytokine concentrations declined over time (p < 0.05 for all), but no differences between obese and non-obese patients were observed. Also, BMI did not correlate with the cytokine response (IL-6 r = 0.09, p = 0.61, TNF-α r = 0.03, p = 0.99, IP-10 r = 0.28, p = 0.11). The kinetics of clinical inflammatory parameters and respiratory mechanics were also similar in both groups. Finally, no differences in time on ventilator, ICU length of stay or 40-day mortality between obese and non-obese patients were apparent. CONCLUSIONSIn COVID-19 patients requiring mechanical ventilation in the ICU, a higher BMI is not related to a different immunological response, unfavorable respiratory mechanics, or impaired outcome. Background/objectivesObesity appears to be an independent risk factor for ICU admission and a severe disease course in COVID-19 patients. An aberrant inflammatory response and impaired respiratory function have been suggested as underlying mechanisms. We investigated whether obesity is associated with differences in inflammatory, respiratory, and clinical outcome parameters in critically ill COVID-19 patients.Subjects/methodsSixty-seven COVID-19 ICU patients were divided into obese (BMI ≥ 30 kg/m2, n = 18, 72% class I obesity, 28% class II obesity) and non-obese (BMI < 30 kg/m2, n = 49) groups. Concentrations of circulating interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), interferon gamma-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, and IL-1 receptor antagonist (RA) were determined from ICU admission until 10 days afterward, and routine laboratory and clinical parameters were collected.ResultsBMI was 32.6 [31.2–34.5] and 26.0 [24.4–27.7] kg/m2 in the obese and non-obese group, respectively. Apart from temperature, which was significantly lower in obese patients (38.1 [36.9–38.9] vs. 38.7 [38.0 −39.5] °C, p = 0.02), there were no between-group differences on ICU admission. Plasma cytokine concentrations declined over time (p < 0.05 for all), but no differences between obese and non-obese patients were observed. Also, BMI did not correlate with the cytokine response (IL-6 r = 0.09, p = 0.61, TNF-α r = 0.03, p = 0.99, IP-10 r = 0.28, p = 0.11). The kinetics of clinical inflammatory parameters and respiratory mechanics were also similar in both groups. Finally, no differences in time on ventilator, ICU length of stay or 40-day mortality between obese and non-obese patients were apparent.ConclusionsIn COVID-19 patients requiring mechanical ventilation in the ICU, a higher BMI is not related to a different immunological response, unfavorable respiratory mechanics, or impaired outcome. |
Audience | Academic |
Author | Janssen, Nico A F Netea, Mihai G Kox, Matthijs Grondman, Inge van der Hoeven, Johannes G Pickkers, Peter van de Veerdonk, Frank L de Nooijer, Aline H Kooistra, Emma J Claassen, Wout J |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33495522$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1038/s41366-020-0597-4 10.1016/j.rmed.2017.01.004 10.1007/s00134-020-05991-x 10.1186/s13054-016-1360-z 10.1177/2047487320939675 10.1186/1741-7015-12-61 10.1136/bmj.m1966 10.1016/j.orcp.2020.07.002 10.1007/s00134-019-05594-1 10.1161/CIRCULATIONAHA.106.171016 10.1056/NEJM200005043421801 10.1002/oby.22856 10.2337/dc20-0682 10.1097/CCM.0000000000004626 10.1016/j.jaci.2020.04.006 10.1002/oby.22831 10.1136/bmj.f5061 10.1016/S0140-6736(20)30566-3 10.1001/jamainternmed.2019.4346 |
ContentType | Journal Article |
Contributor | Gerretsen, Jelle van Schaik, Tirsa Nijman, Gerine van der Eng, Hetty Joosten, Irma Fasse, Esther Jaeger, Martin van Cranenbroek, Bram Kolkman, Manon Heesakkers, Hidde Rahamat-Langendoen, Janette Hemelaar, Pleun Moorlag, Simone Debisarun, Priya Beunders, Remi Buijsse, Leonie van Rijssen, Esther Frenzel, Tim Klop-Riehl, Margreet van Crevel, Reinout Waalders, Nicole Joosten, Leo Bleeker-Rovers, Chantal Lemmers, Heidi Hopman, Joost Roovers, Noortje Wertheim, Heiman van de Maat, Josephine Smeets, Ruben Kouijzer, Ilse Schouten, Jeroen Dijkstra, Helga Koenen, Hans van der Velde, Sjef de Mast, Quirijn Taks, Esther |
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Copyright | COPYRIGHT 2021 Nature Publishing Group The Author(s), under exclusive licence to Springer Nature Limited 2021. The Author(s), under exclusive licence to Springer Nature Limited 2021 |
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PublicationTitle | International Journal of Obesity |
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References | SC Auld (747_CR11) 2020; 48 SW Littleton (747_CR9) 2017; 124 X Li (747_CR2) 2020; 146 A Hussain (747_CR7) 2020; 14 RG Brower (747_CR15) 2000; 342 F Zhou (747_CR1) 2020; 395 747_CR12 S Gupta (747_CR13) 2020; 180 S Chiappetta (747_CR16) 2020; 44 747_CR14 D Mertz (747_CR8) 2013; 347 CM Petrilli (747_CR4) 2020; 369 DJ Pepper (747_CR19) 2016; 20 M Schetz (747_CR20) 2019; 45 IL Kruglikov (747_CR10) 2020; 28 F Gao (747_CR17) 2020; 43 A Simonnet (747_CR6) 2020; 28 W Nie (747_CR18) 2014; 12 P Poirier (747_CR5) 2006; 113 Q Ruan (747_CR3) 2020; 46 |
References_xml | – volume: 44 start-page: 1790 year: 2020 ident: 747_CR16 publication-title: Int J Obes doi: 10.1038/s41366-020-0597-4 contributor: fullname: S Chiappetta – volume: 124 start-page: 15 year: 2017 ident: 747_CR9 publication-title: Respir Med doi: 10.1016/j.rmed.2017.01.004 contributor: fullname: SW Littleton – ident: 747_CR14 – volume: 46 start-page: 846 year: 2020 ident: 747_CR3 publication-title: Intensive Care Med doi: 10.1007/s00134-020-05991-x contributor: fullname: Q Ruan – volume: 20 year: 2016 ident: 747_CR19 publication-title: Crit Care doi: 10.1186/s13054-016-1360-z contributor: fullname: DJ Pepper – ident: 747_CR12 doi: 10.1177/2047487320939675 – volume: 12 year: 2014 ident: 747_CR18 publication-title: BMC Med doi: 10.1186/1741-7015-12-61 contributor: fullname: W Nie – volume: 369 start-page: m1966 year: 2020 ident: 747_CR4 publication-title: BMJ. doi: 10.1136/bmj.m1966 contributor: fullname: CM Petrilli – volume: 14 start-page: 295 year: 2020 ident: 747_CR7 publication-title: Meta-analysis. Obes Res Clin Pract doi: 10.1016/j.orcp.2020.07.002 contributor: fullname: A Hussain – volume: 45 start-page: 757 year: 2019 ident: 747_CR20 publication-title: Intensive Care Med doi: 10.1007/s00134-019-05594-1 contributor: fullname: M Schetz – volume: 113 start-page: 898 year: 2006 ident: 747_CR5 publication-title: Circulation. doi: 10.1161/CIRCULATIONAHA.106.171016 contributor: fullname: P Poirier – volume: 342 start-page: 1301 year: 2000 ident: 747_CR15 publication-title: N Engl J Med doi: 10.1056/NEJM200005043421801 contributor: fullname: RG Brower – volume: 28 start-page: 1187 year: 2020 ident: 747_CR10 publication-title: Obesity doi: 10.1002/oby.22856 contributor: fullname: IL Kruglikov – volume: 43 start-page: e72 year: 2020 ident: 747_CR17 publication-title: Diabetes Care doi: 10.2337/dc20-0682 contributor: fullname: F Gao – volume: 48 start-page: e799 year: 2020 ident: 747_CR11 publication-title: Crit Care Med doi: 10.1097/CCM.0000000000004626 contributor: fullname: SC Auld – volume: 146 start-page: 110 year: 2020 ident: 747_CR2 publication-title: J Allergy Clin Immunol doi: 10.1016/j.jaci.2020.04.006 contributor: fullname: X Li – volume: 28 start-page: 1195 year: 2020 ident: 747_CR6 publication-title: Obesity doi: 10.1002/oby.22831 contributor: fullname: A Simonnet – volume: 347 start-page: f5061 year: 2013 ident: 747_CR8 publication-title: BMJ. doi: 10.1136/bmj.f5061 contributor: fullname: D Mertz – volume: 395 start-page: 1054 year: 2020 ident: 747_CR1 publication-title: Lancet. doi: 10.1016/S0140-6736(20)30566-3 contributor: fullname: F Zhou – volume: 180 start-page: 1 year: 2020 ident: 747_CR13 publication-title: JAMA Intern Med doi: 10.1001/jamainternmed.2019.4346 contributor: fullname: S Gupta |
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Snippet | Obesity appears to be an independent risk factor for ICU admission and a severe disease course in COVID-19 patients. An aberrant inflammatory response and... Background/objectives Obesity appears to be an independent risk factor for ICU admission and a severe disease course in COVID-19 patients. An aberrant... Background/objectivesObesity appears to be an independent risk factor for ICU admission and a severe disease course in COVID-19 patients. An aberrant... BACKGROUND/OBJECTIVESObesity appears to be an independent risk factor for ICU admission and a severe disease course in COVID-19 patients. An aberrant... |
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SubjectTerms | Aged Body Mass Index Complications and side effects Coronaviruses COVID-19 COVID-19 - complications COVID-19 - epidemiology COVID-19 - immunology COVID-19 - mortality Critical Illness Cytokines Cytokines - blood Female Health aspects Hospital patients Humans Immune response Immune system Immunology Inflammation Inflammatory response Influence Interferon Interleukin 1 Interleukin 1 receptor antagonist Interleukin 10 Interleukin 6 Interleukin 8 IP-10 protein Male Mechanical ventilation Mechanics (physics) Middle Aged Monocyte chemoattractant protein Monocytes Obesity Obesity - complications Parameters Physiological aspects Prospective Studies Proteins Respiratory function Risk analysis Risk factors Statistics Tumor necrosis factor-TNF Tumor necrosis factor-α Ventilation γ-Interferon |
Title | A higher BMI is not associated with a different immune response and disease course in critically ill COVID-19 patients |
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