Cardiovascular Changes Associated with Hypertensive Heart Disease and Aging

Cardiovascular diseases are the leading cause of mortality and morbidity worldwide and account for more than 17.9 million deaths (World Health Organization report). Hypertension and aging are two major risk factors for the development of cardiac structural and functional abnormalities. Hypertension,...

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Published inCell transplantation Vol. 29; p. 96368972092083
Main Authors Saheera, Sherin, Krishnamurthy, Prasanna
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.01.2020
Sage Publications Ltd
SAGE Publishing
Subjects
Aging
Blood pressure
Cardiovascular disease
Cardiovascular diseases
Cardiovascular system
Congestive heart failure
Coronary artery disease
Heart
Hypertension
Hypertrophy
Molecular modelling
Morbidity
Risk factors
Structure-function relationships
Ventricle
heart failure
aging
cardiac hypertrophy
hypertension
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Abstract Cardiovascular diseases are the leading cause of mortality and morbidity worldwide and account for more than 17.9 million deaths (World Health Organization report). Hypertension and aging are two major risk factors for the development of cardiac structural and functional abnormalities. Hypertension, or elevated blood pressure, if left untreated can result in myocardial hypertrophy leading to heart failure (HF). Left ventricular hypertrophy consequent to pressure overload is recognized as the most important predictor of congestive HF and sudden death. The pathological changes occurring during hypertensive heart disease are very complex and involve many cellular and molecular alterations. In contrast, the cardiac changes that occur with aging are a slow but life-long process and involve all of the structural components in the heart and vasculature. However, these structural changes in the cardiovascular system lead to alterations in overall cardiac physiology and function. The pace at which these pathophysiological changes occur varies between individuals owing to many genetic and environmental risk factors. This review highlights the molecular mechanisms of cardiac structural and functional alterations associated with hypertension and aging.
AbstractList Cardiovascular diseases are the leading cause of mortality and morbidity worldwide and account for more than 17.9 million deaths (World Health Organization report). Hypertension and aging are two major risk factors for the development of cardiac structural and functional abnormalities. Hypertension, or elevated blood pressure, if left untreated can result in myocardial hypertrophy leading to heart failure (HF). Left ventricular hypertrophy consequent to pressure overload is recognized as the most important predictor of congestive HF and sudden death. The pathological changes occurring during hypertensive heart disease are very complex and involve many cellular and molecular alterations. In contrast, the cardiac changes that occur with aging are a slow but life-long process and involve all of the structural components in the heart and vasculature. However, these structural changes in the cardiovascular system lead to alterations in overall cardiac physiology and function. The pace at which these pathophysiological changes occur varies between individuals owing to many genetic and environmental risk factors. This review highlights the molecular mechanisms of cardiac structural and functional alterations associated with hypertension and aging.Cardiovascular diseases are the leading cause of mortality and morbidity worldwide and account for more than 17.9 million deaths (World Health Organization report). Hypertension and aging are two major risk factors for the development of cardiac structural and functional abnormalities. Hypertension, or elevated blood pressure, if left untreated can result in myocardial hypertrophy leading to heart failure (HF). Left ventricular hypertrophy consequent to pressure overload is recognized as the most important predictor of congestive HF and sudden death. The pathological changes occurring during hypertensive heart disease are very complex and involve many cellular and molecular alterations. In contrast, the cardiac changes that occur with aging are a slow but life-long process and involve all of the structural components in the heart and vasculature. However, these structural changes in the cardiovascular system lead to alterations in overall cardiac physiology and function. The pace at which these pathophysiological changes occur varies between individuals owing to many genetic and environmental risk factors. This review highlights the molecular mechanisms of cardiac structural and functional alterations associated with hypertension and aging.
Cardiovascular diseases are the leading cause of mortality and morbidity worldwide and account for more than 17.9 million deaths (World Health Organization report). Hypertension and aging are two major risk factors for the development of cardiac structural and functional abnormalities. Hypertension, or elevated blood pressure, if left untreated can result in myocardial hypertrophy leading to heart failure (HF). Left ventricular hypertrophy consequent to pressure overload is recognized as the most important predictor of congestive HF and sudden death. The pathological changes occurring during hypertensive heart disease are very complex and involve many cellular and molecular alterations. In contrast, the cardiac changes that occur with aging are a slow but life-long process and involve all of the structural components in the heart and vasculature. However, these structural changes in the cardiovascular system lead to alterations in overall cardiac physiology and function. The pace at which these pathophysiological changes occur varies between individuals owing to many genetic and environmental risk factors. This review highlights the molecular mechanisms of cardiac structural and functional alterations associated with hypertension and aging.
Author Krishnamurthy, Prasanna
Saheera, Sherin
AuthorAffiliation 1 Department of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, USA
2 Department of Biomedical Engineering, School of Medicine and School of Engineering, The University of Alabama at Birmingham, USA
AuthorAffiliation_xml – name: 1 Department of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, USA
– name: 2 Department of Biomedical Engineering, School of Medicine and School of Engineering, The University of Alabama at Birmingham, USA
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Keywords heart failure
aging
cardiac hypertrophy
hypertension
Language English
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Snippet Cardiovascular diseases are the leading cause of mortality and morbidity worldwide and account for more than 17.9 million deaths (World Health Organization...
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SubjectTerms Aging
Blood pressure
Cardiovascular disease
Cardiovascular diseases
Cardiovascular system
Congestive heart failure
Coronary artery disease
Heart
Hypertension
Hypertrophy
Molecular modelling
Morbidity
Risk factors
Structure-function relationships
Ventricle
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Title Cardiovascular Changes Associated with Hypertensive Heart Disease and Aging
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Volume 29
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