A Split-Mouth Study to Evaluate the Adjunctive Role of Guided Pocket Recolonization (GPR) to Non-Surgical Periodontal Therapy

ABSTRACT Background: The purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic Saccharomyces boulardii (S. boulardii) when administered subgingivally as a supplement to scaling and root planing (SRP) in the treatment of chronic periodonti...

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Published inJournal of pharmacy & bioallied science Vol. 16; no. Suppl 4; pp. S3752 - S3754
Main Authors Khan, Yasir Shahab, Brahma, Bikram Singh, Srivastava, Amitabh, Srivastava, Vivek, Yadav, Shivam, Sahney, Tanu
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer - Medknow 01.12.2024
Medknow Publications and Media Pvt. Ltd
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Abstract ABSTRACT Background: The purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic Saccharomyces boulardii (S. boulardii) when administered subgingivally as a supplement to scaling and root planing (SRP) in the treatment of chronic periodontitis. In addition, the N benzoyl DL arginine naphthylamide (BANA) test was used to examine the impact of probiotics on red complex organisms. Materials and Methods: Twenty systemically healthy participants with chronic periodontitis, with at least two periodontal pockets in each quadrant exhibiting probing depth (PD) ≥5 mm and clinical attachment level (CAL) ≥3 mm, participated in this split-mouth randomized controlled research. Two randomly chosen sites were chosen for each subject: one for testing, where SRP was followed by subgingival placement of the probiotic-prebiotic cocktail, and the other for control, where SRP alone was used. Assessments were conducted from baseline to 6 months later for the plaque index (PI), gingival index (GI), PD, and CAL. BANA was used to perform microbial assessments at baseline and at 1, 3, and 6 months. At certain intervals, the probiotic's (S. boulardii) vitality was assessed both in vitro and in the pocket. Results: In both groups, there was a significant decrease in every clinical measure. A noteworthy enhancement was seen in the test group's PI, GI, PPD, and CAL upon intergroup comparison in contrast to the control group. When comparing groups, it was shown that the test group's BANA had significantly decreased after 3 and 6 months. While there was a significant difference and increase in in vitro vitality between the days, there was a significant difference and decrease in in vivo viability in the days that followed as compared to the day before. Conclusion: In comparison to SRP alone, subgingival administration of a probiotic-prebiotic mixture can be advantageous in non-surgical periodontal therapy for patients with chronic periodontitis and in managing the red complex organism's recolonization over time.
AbstractList ABSTRACT Background: The purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic Saccharomyces boulardii (S. boulardii) when administered subgingivally as a supplement to scaling and root planing (SRP) in the treatment of chronic periodontitis. In addition, the N benzoyl DL arginine naphthylamide (BANA) test was used to examine the impact of probiotics on red complex organisms. Materials and Methods: Twenty systemically healthy participants with chronic periodontitis, with at least two periodontal pockets in each quadrant exhibiting probing depth (PD) ≥5 mm and clinical attachment level (CAL) ≥3 mm, participated in this split-mouth randomized controlled research. Two randomly chosen sites were chosen for each subject: one for testing, where SRP was followed by subgingival placement of the probiotic-prebiotic cocktail, and the other for control, where SRP alone was used. Assessments were conducted from baseline to 6 months later for the plaque index (PI), gingival index (GI), PD, and CAL. BANA was used to perform microbial assessments at baseline and at 1, 3, and 6 months. At certain intervals, the probiotic's (S. boulardii) vitality was assessed both in vitro and in the pocket. Results: In both groups, there was a significant decrease in every clinical measure. A noteworthy enhancement was seen in the test group's PI, GI, PPD, and CAL upon intergroup comparison in contrast to the control group. When comparing groups, it was shown that the test group's BANA had significantly decreased after 3 and 6 months. While there was a significant difference and increase in in vitro vitality between the days, there was a significant difference and decrease in in vivo viability in the days that followed as compared to the day before. Conclusion: In comparison to SRP alone, subgingival administration of a probiotic-prebiotic mixture can be advantageous in non-surgical periodontal therapy for patients with chronic periodontitis and in managing the red complex organism's recolonization over time.
Background: The purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic Saccharomyces boulardii (S. boulardii) when administered subgingivally as a supplement to scaling and root planing (SRP) in the treatment of chronic periodontitis. In addition, the N benzoyl DL arginine naphthylamide (BANA) test was used to examine the impact of probiotics on red complex organisms. Materials and Methods: Twenty systemically healthy participants with chronic periodontitis, with at least two periodontal pockets in each quadrant exhibiting probing depth (PD) ≥5 mm and clinical attachment level (CAL) ≥3 mm, participated in this split-mouth randomized controlled research. Two randomly chosen sites were chosen for each subject: one for testing, where SRP was followed by subgingival placement of the probiotic-prebiotic cocktail, and the other for control, where SRP alone was used. Assessments were conducted from baseline to 6 months later for the plaque index (PI), gingival index (GI), PD, and CAL. BANA was used to perform microbial assessments at baseline and at 1, 3, and 6 months. At certain intervals, the probiotic’s (S. boulardii) vitality was assessed both in vitro and in the pocket. Results: In both groups, there was a significant decrease in every clinical measure. A noteworthy enhancement was seen in the test group’s PI, GI, PPD, and CAL upon intergroup comparison in contrast to the control group. When comparing groups, it was shown that the test group’s BANA had significantly decreased after 3 and 6 months. While there was a significant difference and increase in in vitro vitality between the days, there was a significant difference and decrease in in vivo viability in the days that followed as compared to the day before. Conclusion: In comparison to SRP alone, subgingival administration of a probiotic-prebiotic mixture can be advantageous in non-surgical periodontal therapy for patients with chronic periodontitis and in managing the red complex organism’s recolonization over time.
The purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic Saccharomyces boulardii (S. boulardii) when administered subgingivally as a supplement to scaling and root planing (SRP) in the treatment of chronic periodontitis. In addition, the N benzoyl DL arginine naphthylamide (BANA) test was used to examine the impact of probiotics on red complex organisms. Twenty systemically healthy participants with chronic periodontitis, with at least two periodontal pockets in each quadrant exhibiting probing depth (PD) ≥5 mm and clinical attachment level (CAL) ≥3 mm, participated in this split-mouth randomized controlled research. Two randomly chosen sites were chosen for each subject: one for testing, where SRP was followed by subgingival placement of the probiotic-prebiotic cocktail, and the other for control, where SRP alone was used. Assessments were conducted from baseline to 6 months later for the plaque index (PI), gingival index (GI), PD, and CAL. BANA was used to perform microbial assessments at baseline and at 1, 3, and 6 months. At certain intervals, the probiotic's (S. boulardii) vitality was assessed both in vitro and in the pocket. In both groups, there was a significant decrease in every clinical measure. A noteworthy enhancement was seen in the test group's PI, GI, PPD, and CAL upon intergroup comparison in contrast to the control group. When comparing groups, it was shown that the test group's BANA had significantly decreased after 3 and 6 months. While there was a significant difference and increase in in vitro vitality between the days, there was a significant difference and decrease in in vivo viability in the days that followed as compared to the day before. In comparison to SRP alone, subgingival administration of a probiotic-prebiotic mixture can be advantageous in non-surgical periodontal therapy for patients with chronic periodontitis and in managing the red complex organism's recolonization over time.
ABSTRACTBackground:The purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic Saccharomyces boulardii (S. boulardii) when administered subgingivally as a supplement to scaling and root planing (SRP) in the treatment of chronic periodontitis. In addition, the N benzoyl DL arginine naphthylamide (BANA) test was used to examine the impact of probiotics on red complex organisms.Materials and Methods:Twenty systemically healthy participants with chronic periodontitis, with at least two periodontal pockets in each quadrant exhibiting probing depth (PD) ≥5 mm and clinical attachment level (CAL) ≥3 mm, participated in this split-mouth randomized controlled research. Two randomly chosen sites were chosen for each subject: one for testing, where SRP was followed by subgingival placement of the probiotic-prebiotic cocktail, and the other for control, where SRP alone was used. Assessments were conducted from baseline to 6 months later for the plaque index (PI), gingival index (GI), PD, and CAL. BANA was used to perform microbial assessments at baseline and at 1, 3, and 6 months. At certain intervals, the probiotic’s (S. boulardii) vitality was assessed both in vitro and in the pocket.Results:In both groups, there was a significant decrease in every clinical measure. A noteworthy enhancement was seen in the test group’s PI, GI, PPD, and CAL upon intergroup comparison in contrast to the control group. When comparing groups, it was shown that the test group’s BANA had significantly decreased after 3 and 6 months. While there was a significant difference and increase in in vitro vitality between the days, there was a significant difference and decrease in in vivo viability in the days that followed as compared to the day before.Conclusion:In comparison to SRP alone, subgingival administration of a probiotic-prebiotic mixture can be advantageous in non-surgical periodontal therapy for patients with chronic periodontitis and in managing the red complex organism’s recolonization over time.
ABSTRACT Background: The purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic Saccharomyces boulardii (S. boulardii) when administered subgingivally as a supplement to scaling and root planing (SRP) in the treatment of chronic periodontitis. In addition, the N benzoyl DL arginine naphthylamide (BANA) test was used to examine the impact of probiotics on red complex organisms. Materials and Methods: Twenty systemically healthy participants with chronic periodontitis, with at least two periodontal pockets in each quadrant exhibiting probing depth (PD) ≥5 mm and clinical attachment level (CAL) ≥3 mm, participated in this split-mouth randomized controlled research. Two randomly chosen sites were chosen for each subject: one for testing, where SRP was followed by subgingival placement of the probiotic-prebiotic cocktail, and the other for control, where SRP alone was used. Assessments were conducted from baseline to 6 months later for the plaque index (PI), gingival index (GI), PD, and CAL. BANA was used to perform microbial assessments at baseline and at 1, 3, and 6 months. At certain intervals, the probiotic's (S. boulardii) vitality was assessed both in vitro and in the pocket. Results: In both groups, there was a significant decrease in every clinical measure. A noteworthy enhancement was seen in the test group's PI, GI, PPD, and CAL upon intergroup comparison in contrast to the control group. When comparing groups, it was shown that the test group's BANA had significantly decreased after 3 and 6 months. While there was a significant difference and increase in in vitro vitality between the days, there was a significant difference and decrease in in vivo viability in the days that followed as compared to the day before. Conclusion: In comparison to SRP alone, subgingival administration of a probiotic-prebiotic mixture can be advantageous in non-surgical periodontal therapy for patients with chronic periodontitis and in managing the red complex organism's recolonization over time. Keywords: Chronic Periodontitis, Probiotic-Prebiotic Therapy, Red Complex Organisms
The purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic Saccharomyces boulardii (S. boulardii) when administered subgingivally as a supplement to scaling and root planing (SRP) in the treatment of chronic periodontitis. In addition, the N benzoyl DL arginine naphthylamide (BANA) test was used to examine the impact of probiotics on red complex organisms.BackgroundThe purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic Saccharomyces boulardii (S. boulardii) when administered subgingivally as a supplement to scaling and root planing (SRP) in the treatment of chronic periodontitis. In addition, the N benzoyl DL arginine naphthylamide (BANA) test was used to examine the impact of probiotics on red complex organisms.Twenty systemically healthy participants with chronic periodontitis, with at least two periodontal pockets in each quadrant exhibiting probing depth (PD) ≥5 mm and clinical attachment level (CAL) ≥3 mm, participated in this split-mouth randomized controlled research. Two randomly chosen sites were chosen for each subject: one for testing, where SRP was followed by subgingival placement of the probiotic-prebiotic cocktail, and the other for control, where SRP alone was used. Assessments were conducted from baseline to 6 months later for the plaque index (PI), gingival index (GI), PD, and CAL. BANA was used to perform microbial assessments at baseline and at 1, 3, and 6 months. At certain intervals, the probiotic's (S. boulardii) vitality was assessed both in vitro and in the pocket.Materials and MethodsTwenty systemically healthy participants with chronic periodontitis, with at least two periodontal pockets in each quadrant exhibiting probing depth (PD) ≥5 mm and clinical attachment level (CAL) ≥3 mm, participated in this split-mouth randomized controlled research. Two randomly chosen sites were chosen for each subject: one for testing, where SRP was followed by subgingival placement of the probiotic-prebiotic cocktail, and the other for control, where SRP alone was used. Assessments were conducted from baseline to 6 months later for the plaque index (PI), gingival index (GI), PD, and CAL. BANA was used to perform microbial assessments at baseline and at 1, 3, and 6 months. At certain intervals, the probiotic's (S. boulardii) vitality was assessed both in vitro and in the pocket.In both groups, there was a significant decrease in every clinical measure. A noteworthy enhancement was seen in the test group's PI, GI, PPD, and CAL upon intergroup comparison in contrast to the control group. When comparing groups, it was shown that the test group's BANA had significantly decreased after 3 and 6 months. While there was a significant difference and increase in in vitro vitality between the days, there was a significant difference and decrease in in vivo viability in the days that followed as compared to the day before.ResultsIn both groups, there was a significant decrease in every clinical measure. A noteworthy enhancement was seen in the test group's PI, GI, PPD, and CAL upon intergroup comparison in contrast to the control group. When comparing groups, it was shown that the test group's BANA had significantly decreased after 3 and 6 months. While there was a significant difference and increase in in vitro vitality between the days, there was a significant difference and decrease in in vivo viability in the days that followed as compared to the day before.In comparison to SRP alone, subgingival administration of a probiotic-prebiotic mixture can be advantageous in non-surgical periodontal therapy for patients with chronic periodontitis and in managing the red complex organism's recolonization over time.ConclusionIn comparison to SRP alone, subgingival administration of a probiotic-prebiotic mixture can be advantageous in non-surgical periodontal therapy for patients with chronic periodontitis and in managing the red complex organism's recolonization over time.
The purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic ( ) when administered subgingivally as a supplement to scaling and root planing (SRP) in the treatment of chronic periodontitis. In addition, the N benzoyl DL arginine naphthylamide (BANA) test was used to examine the impact of probiotics on red complex organisms. Twenty systemically healthy participants with chronic periodontitis, with at least two periodontal pockets in each quadrant exhibiting probing depth (PD) ≥5 mm and clinical attachment level (CAL) ≥3 mm, participated in this split-mouth randomized controlled research. Two randomly chosen sites were chosen for each subject: one for testing, where SRP was followed by subgingival placement of the probiotic-prebiotic cocktail, and the other for control, where SRP alone was used. Assessments were conducted from baseline to 6 months later for the plaque index (PI), gingival index (GI), PD, and CAL. BANA was used to perform microbial assessments at baseline and at 1, 3, and 6 months. At certain intervals, the probiotic's ( ) vitality was assessed both and in the pocket. In both groups, there was a significant decrease in every clinical measure. A noteworthy enhancement was seen in the test group's PI, GI, PPD, and CAL upon intergroup comparison in contrast to the control group. When comparing groups, it was shown that the test group's BANA had significantly decreased after 3 and 6 months. While there was a significant difference and increase in vitality between the days, there was a significant difference and decrease in viability in the days that followed as compared to the day before. In comparison to SRP alone, subgingival administration of a probiotic-prebiotic mixture can be advantageous in non-surgical periodontal therapy for patients with chronic periodontitis and in managing the red complex organism's recolonization over time.
Audience Academic
Author Yadav, Shivam
Khan, Yasir Shahab
Srivastava, Amitabh
Sahney, Tanu
Brahma, Bikram Singh
Srivastava, Vivek
AuthorAffiliation 2 Department of Dentistry, Autonomous State Medical College, Hardoi, Uttar Pradesh, India
1 Department of Periodontology, Sardar Patel Post Graduate Institute of Medical and Dental Sciences, Lucknow, Uttar Pradesh, India
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Cites_doi 10.4103/0972-124X.154167
10.4103/ijohs.ijohs_10_18
10.5005/jp-journals-10029-1145
10.1155/2013/587279
10.1111/prd.12304
10.1177/154405910708601111
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Issue Suppl 4
Keywords Red Complex Organisms
Chronic Periodontitis
Probiotic-Prebiotic Therapy
Language English
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  doi: 10.1177/154405910708601111
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Snippet ABSTRACT Background: The purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic Saccharomyces...
The purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic ( ) when administered subgingivally as...
ABSTRACT Background: The purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic Saccharomyces...
The purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic Saccharomyces boulardii (S. boulardii)...
ABSTRACTBackground:The purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic Saccharomyces...
Background: The purpose of the study was to assess the effectiveness of prebiotic fructooligosaccharide (FOS) mixture and probiotic Saccharomyces boulardii (S....
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SubjectTerms chronic periodontitis
Dietary supplements
Fructooligosaccharides
Gingiva
Gingival index
Gum disease
Original Research
Periodontitis
Plaque index
Prebiotics
probiotic-prebiotic therapy
Probiotics
Recolonization
red complex organisms
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Title A Split-Mouth Study to Evaluate the Adjunctive Role of Guided Pocket Recolonization (GPR) to Non-Surgical Periodontal Therapy
URI https://doi.org/10.4103/jpbs.jpbs_1175_24
https://www.ncbi.nlm.nih.gov/pubmed/39926962
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https://www.proquest.com/docview/3165082347
https://pubmed.ncbi.nlm.nih.gov/PMC11805286
https://doaj.org/article/c7046d0b95e94cb9853f597d91ecabc3
Volume 16
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