The Effect of Chronic Ultraviolet Radiation on the Human Immune System
A single or a limited number of UVR exposures is recognized to suppress cell‐mediated immunity in human subjects. The complex pathway leading from the absorption of photons by chromophores in the skin to the generation of T regulatory cells has been, at least partially, elucidated. However, the effe...
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| Published in | Photochemistry and photobiology Vol. 84; no. 1; pp. 19 - 28 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.01.2008
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0031-8655 1751-1097 |
| DOI | 10.1111/j.1751-1097.2007.00239.x |
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| Abstract | A single or a limited number of UVR exposures is recognized to suppress cell‐mediated immunity in human subjects. The complex pathway leading from the absorption of photons by chromophores in the skin to the generation of T regulatory cells has been, at least partially, elucidated. However, the effect of repeated UV exposures on immune responses and associated mediators is not well studied, particularly to assess whether they lead, first, to the development of photoprotection so that these immune changes are reduced or no longer occur, and, secondly, to the development of photoprotection against the normal downregulation of immunity induced by a high UV dose. For almost all the parameters evaluated in this review—epidermal DNA damage/erythema, urocanic acid, Langerhans and dendritic cells, natural killer cells, macrophages, mast cells, contact and delayed hypersensitivity responses—none, aside from epidermal DNA damage/erythema and macrophage phagocytic activity, show convincing evidence of photoadaptation or, where appropriate, photoprotection. It is concluded that repeatedly irradiating individuals with UVR is likely to continue to result in downregulation of immunity. |
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| AbstractList | AbstractA single or a limited number of UVR exposures is recognized to suppress cell-mediated immunity in human subjects. The complex pathway leading from the absorption of photons by chromophores in the skin to the generation of T regulatory cells has been, at least partially, elucidated. However, the effect of repeated UV exposures on immune responses and associated mediators is not well studied, particularly to assess whether they lead, first, to the development of photoprotection so that these immune changes are reduced or no longer occur, and, secondly, to the development of photoprotection against the normal downregulation of immunity induced by a high UV dose. For almost all the parameters evaluated in this review-epidermal DNA damage/erythema, urocanic acid, Langerhans and dendritic cells, natural killer cells, macrophages, mast cells, contact and delayed hypersensitivity responses-none, aside from epidermal DNA damage/erythema and macrophage phagocytic activity, show convincing evidence of photoadaptation or, where appropriate, photoprotection. It is concluded that repeatedly irradiating individuals with UVR is likely to continue to result in downregulation of immunity. A single or a limited number of UVR exposures is recognized to suppress cell‐mediated immunity in human subjects. The complex pathway leading from the absorption of photons by chromophores in the skin to the generation of T regulatory cells has been, at least partially, elucidated. However, the effect of repeated UV exposures on immune responses and associated mediators is not well studied, particularly to assess whether they lead, first, to the development of photoprotection so that these immune changes are reduced or no longer occur, and, secondly, to the development of photoprotection against the normal downregulation of immunity induced by a high UV dose. For almost all the parameters evaluated in this review—epidermal DNA damage/erythema, urocanic acid, Langerhans and dendritic cells, natural killer cells, macrophages, mast cells, contact and delayed hypersensitivity responses—none, aside from epidermal DNA damage/erythema and macrophage phagocytic activity, show convincing evidence of photoadaptation or, where appropriate, photoprotection. It is concluded that repeatedly irradiating individuals with UVR is likely to continue to result in downregulation of immunity. A single or a limited number of UVR exposures is recognized to suppress cell-mediated immunity in human subjects. The complex pathway leading from the absorption of photons by chromophores in the skin to the generation of T regulatory cells has been, at least partially, elucidated. However, the effect of repeated UV exposures on immune responses and associated mediators is not well studied, particularly to assess whether they lead, first, to the development of photoprotection so that these immune changes are reduced or no longer occur, and, secondly, to the development of photoprotection against the normal downregulation of immunity induced by a high UV dose. For almost all the parameters evaluated in this review--epidermal DNA damage/erythema, urocanic acid, Langerhans and dendritic cells, natural killer cells, macrophages, mast cells, contact and delayed hypersensitivity responses--none, aside from epidermal DNA damage/erythema and macrophage phagocytic activity, show convincing evidence of photoadaptation or, where appropriate, photoprotection. It is concluded that repeatedly irradiating individuals with UVR is likely to continue to result in downregulation of immunity.A single or a limited number of UVR exposures is recognized to suppress cell-mediated immunity in human subjects. The complex pathway leading from the absorption of photons by chromophores in the skin to the generation of T regulatory cells has been, at least partially, elucidated. However, the effect of repeated UV exposures on immune responses and associated mediators is not well studied, particularly to assess whether they lead, first, to the development of photoprotection so that these immune changes are reduced or no longer occur, and, secondly, to the development of photoprotection against the normal downregulation of immunity induced by a high UV dose. For almost all the parameters evaluated in this review--epidermal DNA damage/erythema, urocanic acid, Langerhans and dendritic cells, natural killer cells, macrophages, mast cells, contact and delayed hypersensitivity responses--none, aside from epidermal DNA damage/erythema and macrophage phagocytic activity, show convincing evidence of photoadaptation or, where appropriate, photoprotection. It is concluded that repeatedly irradiating individuals with UVR is likely to continue to result in downregulation of immunity. A single or a limited number of UVR exposures is recognized to suppress cell-mediated immunity in human subjects. The complex pathway leading from the absorption of photons by chromophores in the skin to the generation of T regulatory cells has been, at least partially, elucidated. However, the effect of repeated UV exposures on immune responses and associated mediators is not well studied, particularly to assess whether they lead, first, to the development of photoprotection so that these immune changes are reduced or no longer occur, and, secondly, to the development of photoprotection against the normal downregulation of immunity induced by a high UV dose. For almost all the parameters evaluated in this review-epidermal DNA damage/erythema, urocanic acid, Langerhans and dendritic cells, natural killer cells, macrophages, mast cells, contact and delayed hypersensitivity responses-none, aside from epidermal DNA damage/erythema and macrophage phagocytic activity, show convincing evidence of photoadaptation or, where appropriate, photoprotection. It is concluded that repeatedly irradiating individuals with UVR is likely to continue to result in downregulation of immunity. [PUBLICATION ABSTRACT] |
| Author | Lesiak, Aleksandra Narbutt, Joanna McLoone, Pauline Norval, Mary |
| Author_xml | – sequence: 1 givenname: Mary surname: Norval fullname: Norval, Mary email: m.norval@ed.ac.uk organization: Biomedical Sciences, University of Edinburgh Medical School, Edinburgh, UK – sequence: 2 givenname: Pauline surname: McLoone fullname: McLoone, Pauline organization: Biomedical Sciences, University of Edinburgh Medical School, Edinburgh, UK – sequence: 3 givenname: Aleksandra surname: Lesiak fullname: Lesiak, Aleksandra organization: Dermatology, Medical University of Lodz, Lodz, Poland – sequence: 4 givenname: Joanna surname: Narbutt fullname: Narbutt, Joanna organization: Dermatology, Medical University of Lodz, Lodz, Poland |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18173697$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1007/s00705-005-0561-6 10.1111/j.1751-1097.1998.tb02538.x 10.1111/1523-1747.ep12456257 10.1016/j.mrfmmm.2004.06.059 10.1016/j.jdermsci.2006.11.001 10.1046/j.1523-1747.2002.16602.x 10.1084/jem.187.12.2045 10.1111/j.0022-202X.2005.23731.x 10.1002/cncr.20346 10.1111/1523-1747.ep12365802 10.1016/0190-9622(95)90340-2 10.1586/17469872.1.2.227 10.1046/j.1365-2133.2001.04145.x 10.1111/j.1365-2133.2004.05966.x 10.1562/0031-8655(2003)0770271ECUALC2.0.CO2 10.1111/j.1365-2133.1993.tb03330.x 10.1039/b503166d 10.1111/1523-1747.ep12312309 10.1007/s004030050230 10.1006/cyto.2001.0849 10.1136/jcp.2004.017210 10.1046/j.0022-202x.2001.01478.x 10.1111/j.1600-0781.1995.tb00128.x 10.1096/fj.01-0386com 10.1016/0190-9622(95)90184-1 10.1046/j.1440-1711.2001.01047.x 10.1093/jnci/59.4.1231 10.1111/1523-1747.ep12466123 10.1016/S1011-1344(99)00007-X 10.1111/j.1751-1097.1997.tb01935.x 10.1046/j.1365-2133.2003.05090.x 10.1046/j.1523-1747.1999.00610.x 10.1016/S1011-1344(01)00245-7 10.1562/0031-8655(2003)0780633STBCCI2.0.CO2 10.1046/j.1523-1747.1999.00465.x 10.2302/kjm.54.165 10.1046/j.0022-202x.2001.01545.x 10.1046/j.1523-1747.1999.00523.x 10.1002/jlb.57.6.883 10.1111/1523-1747.ep12491807 10.1080/000155599750010968 10.1111/j.1365-2133.1995.tb02746.x 10.1080/00015550310016481 10.1111/j.0022-202X.2004.23464.x 10.1111/1523-1747.ep12326032 10.1039/b504344a 10.1046/j.1365-2133.2003.05113.x 10.1046/j.1523-1747.1998.00436.x 10.1562/2005-04-10-RA-484 10.1039/b503094c 10.1046/j.1523-1747.1998.00176.x 10.1016/S1011-1344(98)00211-5 10.1111/j.1600-0781.1995.tb00172.x 10.1039/b418378a 10.1111/j.0300-9475.2004.01489.x 10.1111/1523-1747.ep12456090 10.4049/jimmunol.146.6.1717 10.1038/jid.1983.20 10.1001/archderm.1980.01640290069015 10.1046/j.1523-1747.2002.19511.x 10.2340/0001555566290294 10.1046/j.1523-1747.1999.00565.x 10.1016/j.det.2005.08.003 10.1111/j.1365-2133.2000.03698.x 10.1562/0031-8655(2001)0730083AODDIT2.0.CO2 10.1562/0031-8655(2000)0710700TEOSPE2.0.CO2 10.1002/jlb.65.5.573 10.1046/j.1365-2133.1998.02264.x 10.1111/j.1600-0781.2006.00209.x 10.1093/ajcn/56.4.684 10.1016/S1011-1344(00)00087-7 10.1046/j.1523-1747.2000.00050.x 10.1016/j.jphotobiol.2006.01.009 10.1084/jem.158.1.84 10.1111/j.1751-1097.1997.tb03147.x 10.1111/j.1751-1097.1996.tb03002.x 10.1111/j.1365-2249.1994.tb06017.x 10.1111/1523-1747.ep12363652 10.1046/j.1523-1747.2002.01681.x |
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| References | Damian, D. L., R.StC. Barnetson and G. M. Halliday (1999) Low-dose UVA and UVB have different time courses for suppression of contact hypersensitivity to a recall antigen in humans. J. Invest. Dermatol. 112, 939-944. Hanneman, K. K., K. D. Cooper and E. D. Baron (2006) Ultraviolet immunosuppression: Mechanisms and consequences. Dermatol. Clin. 24, 19-25. Poswig, A., J. Wenk, P. Brenneisen, M. Wlaschek, C. Hommel, G. Quel, K. Faisst, J. Dissemond, K. Briviba, T. Kreig and K. Scharffetter-Kochanek (1999) Adaptive antioxidant response of manganese-superoxide dismutase following repetitive UVA irradiation. J. Invest. Dermatol. 112, 13-18. Czernielewski, J. M., I. Masouye, A. Pisani, J. Ferracin, D. Auvolat and J. P. Ortonne (1988) Effect of chronic sun exposure on human Langerhans cell density. Photodermatology 5, 116-120. Kligman, L. H. and G. F. Murphy (1996) Ultraviolet B radiation increases hairless mouse mast cells in a dose-dependent manner and alters distribution of UV-induced mast cell growth factor. Photochem. Photobiol. 63, 123-127. Neill, W. A., K. E. Halliday and M. Norval (1998) Differential effect of phototherapy on the activities of human natural killer cells and cytotoxic T cells. J. Photochem. Photobiol. B, Biol. 47, 129-135. Learn, D. B. and S. J. Moloney (1991) Numbers of murine mast cells remain unchanged during chronic ultraviolet B irradiation. Photodermatol. Photoimmunol. Photomed. 8, 195-199. De Simone, C., C. Masini, M. S. Cattaruzza, C. Guerriero, D. Cerimele and M. Norval (2001) Urocanic acid isomers in patients with non-melanoma skin cancer. Br. J. Dermatol. 144, 858-861. Damian, D. L., G. M. Halliday, C. A. Taylor and R.StC. Barnetson (1998) Ultraviolet radiation induced suppression of Mantoux reactions in humans. J. Invest. Dermatol. 110, 824-827. Sheehan, J. M., N. Cragg, C. A. Chadwick, C. S. Potten and A. R. Young (2002) Repeated ultraviolet exposure affords the same protection against DNA photodamage and erythema in human skin types II and IV but is associated with faster DNA repair in skin type IV. J. Invest. Dermatol. 118, 825-829. Sjovall, P. and O. B. Christensen (1986) Local and systemic effect of ultraviolet irradiation (UVB and UVA) on human allergic contact dermatitis. Acta Derm. Venereol. 66, 290-294. Ross, J. A., S. E. M. Howie, M. Norval, J. Maingay and T. J. Simpson (1986) Ultraviolet-irradiated urocanic acid suppresses delayed-type hypersensitivity to herpes simplex virus. J. Invest. Dermatol. 87, 630-633. Norval, M. (2006) Photoimmunosuppression of contact hypersensitivity. Expert Rev. Dermatol. 1, 227-239. Snellman, E., C. T. Jansen, J. K. Laihia, T. Milan, L. Koulu, K. Leszczynski and P. Pasanen (1997) Urocanic acid concentration and photoisomerisation in Caucasian skin phototypes. Photochem. Photobiol. 65, 862-865. De Winter, S., A. A. Vink, L. Roza and S. Pavel (2001) Solar-simulated skin adaptation and its effect on subsequent UV-induced epidermal DNA damage. J. Invest. Dermatol. 117, 678-682. Bykov, V. J., J. M. Sheehan, K. Hemminki and A. R. Young (1999) In situ repair of cyclobutane pyrimidine dimers and 6-4 photoproducts in human skin exposed to solar simulating radiation. J. Invest. Dermatol. 112, 326-331. Moyal, D. D. and A. M. Fourtanier (2001) Broad-spectrum sunscreens provide better protection from the suppression of the elicitation phase of delayed-type hypersensitivity response in humans. J. Invest. Dermatol. 117, 1186-1192. Grimbaldeston, M. A., J. J. Finlay-Jones and P. H. Hart (2006) Mast cells in photodamaged skin: What is their role in skin cancer? Photochem. Photobiol. 5, 177-183. Meischer, G. (1930) Das problems des lichtchutzes und der lichtgewohnung. Strahlentherapie 35, 403-443. Wassberg, C., H. Backvall, B. Diffey, F. Ponten and B. Berne (2003) Enhanced ultraviolet responses in chronically sun-exposed skin are dependent on previous sun exposure. Acta Derm. Venereol. 83, 254-261. Grimbaldeston, M. A., L. Skov, J. J. Finlay-Jones and P. H. Hart (2002) Squamous cell carcinoma is not associated with high dermal mast cell prevalence in humans. J. Invest. Dermatol. 119, 1204-1206. Jeevan, A., C. D. Bucana, Z. Dong, V. V. Dixon, S. L. Thomas, T. E. Lloyd and M. L. Kripke (1995) Ultraviolet radiation reduces phagocytosis and intracellular killing of mycobacteria and inhibits nitric oxide production by macrophages in mice. J. Leukoc. Biol. 57, 883-890. Leino, L., K. Saarinen, K. Kiviso, L. Koulu, C. T. Jansen and K. Punnonen (1999) Systemic suppression of human peripheral blood phagocytic leukocytes after whole-body UVB irradiation. J. Leukoc. Biol. 65, 573-582. Hart, P. H., M. A. Grimbaldeston, G. J. Swift, A. Jaksic, F. P. Noonan and J. J. Finlay-Jones (1998) Dermal mast cells determine susceptibility to UVB-induced systemic suppression of contact hypersensitivity. J. Exp. Med. 187, 2045-2053. Grimbaldeston, M. A., A. Simpson, J. J. Finlay-Jones and P. H. Hart (2003) The effect of ultraviolet radiation exposure on the prevalence of mast cells in human skin. Br. J. Dermatol. 148, 300-306. Grimbaldeston, M. A., L. Skov, O. Baadsgaard, B. G. Skov, G. Marshman, J. J. Finlay-Jones and P. H. Hart (2000) High dermal mast cell prevalence is a predisposing factor for basal cell carcinoma in humans. J. Invest. Dermatol. 115, 317-320. Schwarz, T. (2005) Mechanisms of UV-induced immunosuppression. Keio J. Med. 54, 165-171. Kim, T. H., S. E. Ullrich, H. N. Ananthaswamy, S. Zimmerman and M. L. Kripke (1998) Suppression of delayed and contact hypersensitivity responses in mice have different UV dose responses. Photochem. Photobiol. 68, 738-744. Cestari, T. F., M. L. Kripke, P. L. Baptista, L. Bakos and C. D. Bucana (1995) Ultraviolet radiation decreases the granulomatous response to lepromin in humans. J. Invest. Dermatol. 105, 8-13. Troost, R. J. J., M. M. A. Kozel, C. G. Van Helden-Meeuwsen, T. Van Joost, P. G. H. Mulder, R. Benner and E. P. Prens (1995) Hyposensitization in nickel allergic contact dermatitis: Clinical and immunologic monitoring. J. Am. Acad. Dermatol. 32, 576-583. Narbutt, J., A. Lesiak, M. Skibinska, A. Wozniacka, H. Van Loveren, A. Sysa-Jedrzejowska, I. Lewy-Trenda, A. Omulscka and M. Norval (2005) Suppression of contact hypersensitivity after repeated exposures of humans to low doses of solar simulated radiation. Photochem. Photobiol. Sci. 4, 517-522. Fuller, C. J., H. Faulkner, A. Bendich, R. S. Parker and D. A. Roe (1992) Effect of β-carotene supplementation on photosuppression of delayed-type hypersensitivity in normal young men. Am. J. Clin. Nutr. 56, 684-690. Hersey, P., M. MacDonald, C. Burns, S. Schibeci, H. Matthews and F. J. Wilkinson (1987) Analysis of the effect of a sunscreen agent on the suppression of natural killer cell activity induced in human subjects by radiation from solarium lamps. J. Invest. Dermatol. 88, 271-276. Kasahara, S., K. Aizawa, M. Okamiya, N. Kazuno, S. Mutoh, H. Fugo, E. L. Cooper and H. Wago (2001) UVB irradiation suppresses cytokine production and innate cellular immune functions in mice. Cytokine 14, 104-111. Grimbaldeston, M. A., A. Green, S. Darlington, B. O. Robertson, G. Marshman, J. J. Finlay-Jones and P. H. Hart (2003) Susceptibility to basal cell carcinoma is associated with high dermal mast cell prevalence in non-sun-exposed skin for an Australian population. Photochem. Photobiol. 78, 633-639. Vink, A. A. and L. Roza (2001) Biological consequences of cyclobutane pyrimidine dimers. J. Photochem. Photobiol. B, Biol. 65, 101-104. Snellman, E., C. T. Jansen, G. Xu, P. Pasanen, J. Laihia and K. Hemminki (2002) Correlation analysis of production and photoisomerisation of epidermal urocanic acid versus induction and repair of DNA photoproducts in the human skin in situ. J. Invest. Dermatol. 118, 893-895. Seite, S., C. Medaisko, F. Christiaens, C. Bredoux, D. Compan, H. Zucchi, D. Lombard and A. Fourtanier (2006) Biological effects of simulated ultraviolet daylight: A new approach to investigate daily photoprotection. Photodermatol. Photoimmunol. Photomed. 22, 67-77. Hersey, P., M. MacDonald, C. Henderson, S. Schibeci, G. D'Alessandro, M. Pryor and F. J. Wilkinson (1988) Suppression of natural killer cell activity in humans by radiation from solarium lamps depleted of UVB. J. Invest. Dermatol. 90, 305-310. De Fine Olivarius, F., H. C. Wulf, J. Crosby and M. Norval (1999) Isomerization of urocanic acid after ultraviolet radiation is influenced by skin pigmentation. J. Photochem. Photobiol. B, Biol. 48, 42-47. Young, A. R., C. A. Chadwick, G. I. Harrison, O. Nikaido, J. Ramsden and C. S. Potten (1998) The similarity of action spectra for thymine dimers in human epidermis and erythema suggests that DNA is the chromophore for erythema. J. Invest. Dermatol. 111, 982-988. Weber, A., J. Knop and M. Maurer (2003) Pattern analysis of human cutaneous mast cell populations by total body surface mapping. Br. J. Dermatol. 148, 224-228. McLoone, P. and M. Norval (2005) Adaptation to the UV-induced suppression of phagocytic activity in murine peritoneal macrophages following chronic exposure to solar simulated radiation. Photochem. Photobiol. Sci. 4, 783-788. Ullrich, S. E. (2005) Mechanisms underlying UV-induced immune suppression. Mutat. Res. 571, 185-205. Moyal, D., C. Courbiere, Y. Le Corre, O. De Lacharriere and C. Hourseau (1997) Immunosuppression induced by chronic solar-simulated irradiation in humans and its prevention by sunscreens. Eur. J. Dermatol. 7, 223-225. Kaarsen, L. L., T. D. Poulsen, F. De Fine Olivarius and H. C. Wulf (1995) Mast cells and elastosis in ultraviolet-irradiated hairless mice. Photodermatol. Photoimmunol. Photomed. 11, 1-5. Grimbaldeston, M. A., A. L. Pearce, B. O. Robertson, B. J. Coventry, G. Marshman, J. J. Finlay-Jones and P. H. Hart (2004) Association between melanoma and dermal mast cell prevalence in sun-unexposed skin. Br. J. Dermatol. 150, 895-903. Hug, D. H. (2004) Association of nonmelanoma skin cancer with second malignancy. Cancer 101, 206-207. Whitmore, S. E. and W. L. Morison (2000) The effect of suntan parlor exposu 2004; 123 2002; 16 2001; 144 1983; 158 1993; 129 2005; 571 2004; 60 1991; 97 1999; 48 1995; 32 2002; 118 1995; 133 2002; 119 1998; 111 1989; 49 1998; 110 1992; 56 1996; 107 1998; 47 1997; 7 1987; 88 1991; 146 2006; 24 1986; 87 2000; 57 2006; 22 1996; 63 2003; 83 2001; 14 2004; 101 1980; 116 2005; 150 1997; 66 1997; 65 2000; 115 1995; 57 1995; 11 1930; 35 2006; 5 2000; 71 1999; 65 2005; 81 2006; 1 1998; 138 1988; 90 1992; 77 1991; 8 1996; 12 2003; 77 1993; 101 2001; 65 1996; 11 2003; 78 1998; 68 1997; 289 2006; 84 1977; 59 2005; 124 1986; 66 1988; 5 1997; 79 2004; 150 2005; 4 2005; 54 1995; 105 2000; 143 1983; 80 1999; 112 2003; 148 1998; 187 2001; 79 2007; 45 2001; 73 1994; 95 2001; 117 2005; 58 e_1_2_6_51_2 e_1_2_6_72_2 e_1_2_6_53_2 e_1_2_6_74_2 e_1_2_6_30_2 e_1_2_6_70_2 e_1_2_6_19_2 e_1_2_6_13_2 e_1_2_6_34_2 e_1_2_6_59_2 e_1_2_6_11_2 e_1_2_6_32_2 Czernielewski J. M. (e_1_2_6_42_2) 1988; 5 e_1_2_6_17_2 e_1_2_6_55_2 e_1_2_6_76_2 e_1_2_6_15_2 e_1_2_6_36_2 e_1_2_6_57_2 De Fine Olivarius F. (e_1_2_6_27_2) 1996; 12 e_1_2_6_62_2 e_1_2_6_64_2 e_1_2_6_85_2 e_1_2_6_20_2 e_1_2_6_81_2 Moodycliffe A. M. (e_1_2_6_39_2) 1992; 77 e_1_2_6_7_2 e_1_2_6_3_2 e_1_2_6_5_2 e_1_2_6_24_2 e_1_2_6_47_2 e_1_2_6_22_2 e_1_2_6_49_2 e_1_2_6_28_2 Alcalay J. (e_1_2_6_38_2) 1989; 49 e_1_2_6_43_2 e_1_2_6_26_2 e_1_2_6_45_2 e_1_2_6_68_2 e_1_2_6_50_2 e_1_2_6_73_2 e_1_2_6_52_2 e_1_2_6_75_2 e_1_2_6_31_2 e_1_2_6_71_2 Sjovall P. (e_1_2_6_78_2) 1986; 66 Moyal D. (e_1_2_6_83_2) 1997; 7 Meischer G. (e_1_2_6_9_2) 1930; 35 e_1_2_6_18_2 Learn D. B. (e_1_2_6_66_2) 1991; 8 e_1_2_6_12_2 e_1_2_6_35_2 e_1_2_6_58_2 e_1_2_6_10_2 e_1_2_6_33_2 e_1_2_6_16_2 e_1_2_6_54_2 e_1_2_6_77_2 e_1_2_6_14_2 e_1_2_6_37_2 e_1_2_6_56_2 e_1_2_6_79_2 e_1_2_6_61_2 e_1_2_6_84_2 e_1_2_6_63_2 e_1_2_6_86_2 e_1_2_6_40_2 e_1_2_6_82_2 Alcalay J. (e_1_2_6_80_2) 1991; 146 Gilchrest B. A. (e_1_2_6_41_2) 1983; 80 e_1_2_6_8_2 e_1_2_6_29_2 e_1_2_6_4_2 e_1_2_6_6_2 O’Dell B. L. (e_1_2_6_87_2) 1980; 116 e_1_2_6_23_2 e_1_2_6_48_2 e_1_2_6_69_2 e_1_2_6_2_2 Norbury K. C. (e_1_2_6_60_2) 1977; 59 e_1_2_6_21_2 e_1_2_6_65_2 e_1_2_6_44_2 e_1_2_6_67_2 e_1_2_6_25_2 e_1_2_6_46_2 |
| References_xml | – reference: De Fine Olivarius, F., H. C. Wulf, J. Crosby and M. Norval (1996) The sunscreening effect of urocanic acid. Photodermatol. Photoimmunol. Photomed. 12, 93-99. – reference: Moodycliffe, A. M., I. Kimber and M. Norval (1992) The effect of ultraviolet B irradiation and urocanic acid isomers on dendritic cell migration. Immunology 77, 394-399. – reference: De Fine Olivarius, F., H. C. Wulf, J. Crosby and M. Norval (1997) Seasonal variation in urocanic acid isomers in human skin. Photochem. Photobiol. 66, 119-123. – reference: Kaarsen, L. L., T. D. Poulsen, F. De Fine Olivarius and H. C. Wulf (1995) Mast cells and elastosis in ultraviolet-irradiated hairless mice. Photodermatol. Photoimmunol. Photomed. 11, 1-5. – reference: Oh, C., A. Hennessy, T. Ha, Y. Bisset, B. Diffey and J. L. Rees (2004) The time course of photoadaptation and pigmentation studied using a novel method to distinguish pigmentation from erythema. J. Invest. Dermatol. 123, 965-972. – reference: Snellman, E., C. T. Jansen, J. K. Laihia, T. Milan, L. Koulu, K. Leszczynski and P. Pasanen (1997) Urocanic acid concentration and photoisomerisation in Caucasian skin phototypes. Photochem. Photobiol. 65, 862-865. – reference: Gilchrest, B. A., G. Szabo, E. Flynn and R. M. Goldwyn (1983) Chronologic and actinically induced aging in human facial skin. J. Invest. Dermatol. 80(Suppl.), 81s-85s. – reference: De Fine Olivarius, F., H. C. Wulf, P. Therkildsen, T. Poulsen, J. Crosby and M. Norval (1997) Urocanic acid isomers: Relation to body site, pigmentation, stratum corneum thickness and photosensitivity. Arch. Dermatol. Res. 289, 501-505. – reference: Vink, A. A. and L. Roza (2001) Biological consequences of cyclobutane pyrimidine dimers. J. Photochem. Photobiol. B, Biol. 65, 101-104. – reference: De Winter, S., A. A. Vink, L. Roza and S. Pavel (2001) Solar-simulated skin adaptation and its effect on subsequent UV-induced epidermal DNA damage. J. Invest. Dermatol. 117, 678-682. – reference: Seite, S., C. Medaisko, F. Christiaens, C. Bredoux, D. Compan, H. Zucchi, D. Lombard and A. Fourtanier (2006) Biological effects of simulated ultraviolet daylight: A new approach to investigate daily photoprotection. Photodermatol. Photoimmunol. Photomed. 22, 67-77. – reference: De Fine Olivarius, F., H. C. Wulf, J. Crosby and M. Norval (1999) Isomerization of urocanic acid after ultraviolet radiation is influenced by skin pigmentation. J. Photochem. Photobiol. B, Biol. 48, 42-47. – reference: Gilmour, J. W., J. P. Vestey, S. George and M. Norval (1993) Effect of phototherapy and urocanic acid isomers on natural killer cell function. J. Invest. Dermatol. 101, 169-174. – reference: Kim, T. H., S. E. Ullrich, H. N. Ananthaswamy, S. Zimmerman and M. L. Kripke (1998) Suppression of delayed and contact hypersensitivity responses in mice have different UV dose responses. Photochem. Photobiol. 68, 738-744. – reference: Fuller, C. J., H. Faulkner, A. Bendich, R. S. Parker and D. A. Roe (1992) Effect of β-carotene supplementation on photosuppression of delayed-type hypersensitivity in normal young men. Am. J. Clin. Nutr. 56, 684-690. – reference: Wassberg, C., H. Backvall, B. Diffey, F. Ponten and B. Berne (2003) Enhanced ultraviolet responses in chronically sun-exposed skin are dependent on previous sun exposure. Acta Derm. Venereol. 83, 254-261. – reference: Jeevan, A., C. D. Bucana, Z. Dong, V. V. Dixon, S. L. Thomas, T. E. Lloyd and M. L. Kripke (1995) Ultraviolet radiation reduces phagocytosis and intracellular killing of mycobacteria and inhibits nitric oxide production by macrophages in mice. J. Leukoc. Biol. 57, 883-890. – reference: Snellman, E., C. T. Jansen, T. Rantanen and P. Pasanen (1997) Epidermal urocanic acid concentration and photoisomerization reactivity in patients with cutaneous malignant melanoma or basal cell carcinoma. Acta Derm. Venereol. 79, 200-203. – reference: Troost, R. J. J., M. M. A. Kozel, C. G. Van Helden-Meeuwsen, T. Van Joost, P. G. H. Mulder, R. Benner and E. P. Prens (1995) Hyposensitization in nickel allergic contact dermatitis: Clinical and immunologic monitoring. J. Am. Acad. Dermatol. 32, 576-583. – reference: Norbury, K. C., M. L. Kripke and M. B. Budmen (1977) In vitro reactivity of macrophages and lymphocytes from ultraviolet-irradiated mice. J. Natl Cancer Inst. 59, 1231-1235. – reference: Clydesdale, G. J., G. W. Dandie and H. K. Muller (2001) Ultraviolet light induced injury: Immunological and inflammatory effects. Immunol. Cell Biol. 79, 547-568. – reference: Grimbaldeston, M. A., A. L. Pearce, B. O. Robertson, B. J. Coventry, G. Marshman, J. J. Finlay-Jones and P. H. Hart (2004) Association between melanoma and dermal mast cell prevalence in sun-unexposed skin. Br. J. Dermatol. 150, 895-903. – reference: Van Praag, M. C., A. A. Mulder, F. H. Claas, B. J. Vermeer and A. M. Mommaas (1994) Long-term ultraviolet B-induced impairment of Langerhans cell function: An immunoelectron microscope study. Clin. Exp. Immunol. 95, 73-77. – reference: Grimbaldeston, M. A., L. Skov, O. Baadsgaard, B. G. Skov, G. Marshman, J. J. Finlay-Jones and P. H. Hart (2000) High dermal mast cell prevalence is a predisposing factor for basal cell carcinoma in humans. J. Invest. Dermatol. 115, 317-320. – reference: Hanneman, K. K., K. D. Cooper and E. D. Baron (2006) Ultraviolet immunosuppression: Mechanisms and consequences. Dermatol. Clin. 24, 19-25. – reference: Sheehan, J. M., N. Cragg, C. A. Chadwick, C. S. Potten and A. R. Young (2002) Repeated ultraviolet exposure affords the same protection against DNA photodamage and erythema in human skin types II and IV but is associated with faster DNA repair in skin type IV. J. Invest. Dermatol. 118, 825-829. – reference: De Fabo, E. C. and F. P. Noonan (1983) Mechanism of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology. J. Exp. Med. 158, 84-98. – reference: Young, A. R., C. A. Chadwick, G. I. Harrison, O. Nikaido, J. Ramsden and C. S. Potten (1998) The similarity of action spectra for thymine dimers in human epidermis and erythema suggests that DNA is the chromophore for erythema. J. Invest. Dermatol. 111, 982-988. – reference: Hersey, P., M. MacDonald, C. Burns, S. Schibeci, H. Matthews and F. J. Wilkinson (1987) Analysis of the effect of a sunscreen agent on the suppression of natural killer cell activity induced in human subjects by radiation from solarium lamps. J. Invest. Dermatol. 88, 271-276. – reference: Leino, L., K. Saarinen, K. Kiviso, L. Koulu, C. T. Jansen and K. Punnonen (1999) Systemic suppression of human peripheral blood phagocytic leukocytes after whole-body UVB irradiation. J. Leukoc. Biol. 65, 573-582. – reference: O'Dell, B. L., R. T. Jessen, L. E. Becker, R. T. Jackson and E. B. Smith (1980) Diminished immune responses in sun-damaged skin. Arch. Dermatol. 116, 559-561. – reference: Lavker, R. M., G. F. Gerberick, D. Veres, C. J. Irwin and K. H. Kaidbey (1995) Cumulative effects from repeated exposures to suberythemal doses of UVB and UVA in human skin. J. Am. Acad. Dermatol. 32, 53-62. – reference: Snopov, S. A., S. M. Kharit, M. Norval and V. V. Ivanova (2005) Circulating leukocyte and cytokine responses to measles and poliovirus vaccination in children after ultraviolet radiation exposures. Arch. Virol. 150, 1729-1743. – reference: Hammerberg, C., N. Duraiswamy and K. D. Cooper (1996) Temporal correlation between UV radiation locally-induced tolerance and the sequential appearance of dermal, then epidermal, class II MHC+CD11b+ monocytic/macrophagic cells. J. Invest. Dermatol. 107, 755-763. – reference: Sjovall, P. and O. B. Christensen (1986) Local and systemic effect of ultraviolet irradiation (UVB and UVA) on human allergic contact dermatitis. Acta Derm. Venereol. 66, 290-294. – reference: Moyal, D., C. Courbiere, Y. Le Corre, O. De Lacharriere and C. Hourseau (1997) Immunosuppression induced by chronic solar-simulated irradiation in humans and its prevention by sunscreens. Eur. J. Dermatol. 7, 223-225. – reference: Damian, D. L., R.StC. Barnetson and G. M. Halliday (1999) Low-dose UVA and UVB have different time courses for suppression of contact hypersensitivity to a recall antigen in humans. J. Invest. Dermatol. 112, 939-944. – reference: Ullrich, S. E. (2005) Mechanisms underlying UV-induced immune suppression. Mutat. Res. 571, 185-205. – reference: McLoone, P., E. Simics, A. Barton, M. Norval and N. K. Gibbs (2005) An action spectrum for the production of cis-urocanic acid in human skin in vivo. J. Invest. Dermatol. 124, 1071-1074. – reference: Damian, D. L., G. M. Halliday, C. A. Taylor and R.StC. Barnetson (1998) Ultraviolet radiation induced suppression of Mantoux reactions in humans. J. Invest. Dermatol. 110, 824-827. – reference: Schwarz, T. (2005) Mechanisms of UV-induced immunosuppression. Keio J. Med. 54, 165-171. – reference: Narbutt, J., A. Lesiak, M. Skibinska, A. Wozniacka, H. Van Loveren, A. Sysa-Jedrzejowska, I. Lewy-Trenda, A. Omulscka and M. Norval (2005) Suppression of contact hypersensitivity after repeated exposures of humans to low doses of solar simulated radiation. Photochem. Photobiol. Sci. 4, 517-522. – reference: Weber, A., J. Knop and M. Maurer (2003) Pattern analysis of human cutaneous mast cell populations by total body surface mapping. Br. J. Dermatol. 148, 224-228. – reference: Sleijffers, A., A. Kammeyer, F. R. De Gruijl, G. J. Boland, J. Van Hattum, W. A. Van Vloten, H. Van Loveren, M. B. Teunissen and J. Garssen (2003) Epidermal cis-urocanic acid levels correlate with lower specific cellular immune responses after hepatitis B vaccination of ultraviolet B-exposed humans. Photochem. Photobiol. 77, 271-275. – reference: Norval, M. (2006) Photoimmunosuppression of contact hypersensitivity. Expert Rev. Dermatol. 1, 227-239. – reference: Narbutt, J., A. Lesiak, J. Boncela, A. Wozniacka and M. Norval (2007) Repeated exposures of humans to low doses of solar simulated radiation lead to limited photoadaptation and photoprotection against UVB-induced erythema and cytokine mRNA up-regulation. J. Dermatol. Sci. 45, 210-212. – reference: Alcalay, J. and M. L. Kripke (1991) Antigen-presenting activity of draining lymph node cells from mice painted with a contact allergen during ultraviolet carcinogenesis. J. Immunol. 146, 1717-1721. – reference: McLoone, P. and M. Norval (2005) Adaptation to the UV-induced suppression of phagocytic activity in murine peritoneal macrophages following chronic exposure to solar simulated radiation. Photochem. Photobiol. Sci. 4, 783-788. – reference: De Fine Olivarius, F., J. Lock-Andersen, F. Gronhoj Larsen, H. C. Wulf, J. Crosby and M. Norval (1998) Urocanic acid isomers in patients with basal cell carcinoma and cutaneous malignant melanoma. Br. J. Dermatol. 138, 986-992. – reference: Meunier, L., Z. Bata-Csorgo and K. D. Cooper (1995) In human dermis, ultraviolet radiation induces expansion of a CD36+ CD11b+ CD1- macrophage subset by infiltration and proliferation; CD1+ Langerhans-like dendritic antigen-presenting cells are concomitantly depleted. J. Invest. Dermatol. 105, 782-788. – reference: Schade, N., C. Esser and J. Krutmann (2005) Ultraviolet B radiation-induced immunosuppression: Molecular mechanisms and cellular alterations. Photochem. Photobiol. Sci. 4, 699-798. – reference: Grimbaldeston, M. A., A. Green, S. Darlington, B. O. Robertson, G. Marshman, J. J. Finlay-Jones and P. H. Hart (2003) Susceptibility to basal cell carcinoma is associated with high dermal mast cell prevalence in non-sun-exposed skin for an Australian population. Photochem. Photobiol. 78, 633-639. – reference: Moyal, D. D. and A. M. Fourtanier (2001) Broad-spectrum sunscreens provide better protection from the suppression of the elicitation phase of delayed-type hypersensitivity response in humans. J. Invest. Dermatol. 117, 1186-1192. – reference: McLoone, P., G. M. Woods and M. Norval (2005) Decrease in Langerhans cells and increase in lymph node dendritic cells following chronic exposure of mice to suberythemal doses of solar simulated radiation. Photochem. Photobiol. 81, 1168-1173. – reference: Duthie, M. S., I. Kimber, R. J. Dearman and M. Norval (2000) Differential effects of UVAI and UVB radiation on Langerhans cell migration in mice. J. Photochem. Photobiol. B, Biol. 57, 123-131. – reference: Grimbaldeston, M. A., L. Skov, J. J. Finlay-Jones and P. H. Hart (2002) Squamous cell carcinoma is not associated with high dermal mast cell prevalence in humans. J. Invest. Dermatol. 119, 1204-1206. – reference: Kligman, L. H. and G. F. Murphy (1996) Ultraviolet B radiation increases hairless mouse mast cells in a dose-dependent manner and alters distribution of UV-induced mast cell growth factor. Photochem. Photobiol. 63, 123-127. – reference: Learn, D. B. and S. J. Moloney (1991) Numbers of murine mast cells remain unchanged during chronic ultraviolet B irradiation. Photodermatol. Photoimmunol. Photomed. 8, 195-199. – reference: Mitchell, D. L., M. Byrom, S. Chiarello and M. G. Lowery (2001) Attenuation of DNA damage in the dermis and epidermis of the albino hairless mouse by chronic exposure to ultraviolet-A and -B radiation. Photochem. Photobiol. 73, 83-89. – reference: Narbutt, J., M. Skibinska, A. Lesiak, A. Wozniacka, A. Sysa-Jedrzewska, B. Cebula, T. Robak and P. Smolewski (2004) Exposure to low doses of solar-simulated radiation induces an increase in the myeloid subtype of blood dendritic cells. Scand. J. Immunol. 60, 429-435. – reference: Neill, W. A., K. E. Halliday and M. Norval (1998) Differential effect of phototherapy on the activities of human natural killer cells and cytotoxic T cells. J. Photochem. Photobiol. B, Biol. 47, 129-135. – reference: Kasahara, S., K. Aizawa, M. Okamiya, N. Kazuno, S. Mutoh, H. Fugo, E. L. Cooper and H. Wago (2001) UVB irradiation suppresses cytokine production and innate cellular immune functions in mice. Cytokine 14, 104-111. – reference: Whitmore, S. E. and W. L. Morison (2000) The effect of suntan parlor exposure on delayed and contact hypersensitivity. Photochem. Photobiol. 71, 700-705. – reference: Janssens, A. S., R. Heide, J. C. Den Hollander, P. G. M. Mulder, B. Tank and A. P. Oranje (2005) Mast cell distribution in normal adult skin. J. Clin. Pathol. 58, 285-289. – reference: Moller, P., H. Wallin, E. Holst and L. E. Knudsen (2002) Sunlight-induced DNA damage in human mononuclear cells. FASEB J. 16, 45-53. – reference: Hersey, P., M. MacDonald, C. Henderson, S. Schibeci, G. D'Alessandro, M. Pryor and F. J. Wilkinson (1988) Suppression of natural killer cell activity in humans by radiation from solarium lamps depleted of UVB. J. Invest. Dermatol. 90, 305-310. – reference: Poswig, A., J. Wenk, P. Brenneisen, M. Wlaschek, C. Hommel, G. Quel, K. Faisst, J. Dissemond, K. Briviba, T. Kreig and K. Scharffetter-Kochanek (1999) Adaptive antioxidant response of manganese-superoxide dismutase following repetitive UVA irradiation. J. Invest. Dermatol. 112, 13-18. – reference: Kavanagh, G., J. Crosby and M. Norval (1995) Urocanic acid isomers in human skin: Analysis of site variation. Br. J. Dermatol. 133, 728-731. – reference: Snellman, E., C. T. Jansen, G. Xu, P. Pasanen, J. Laihia and K. Hemminki (2002) Correlation analysis of production and photoisomerisation of epidermal urocanic acid versus induction and repair of DNA photoproducts in the human skin in situ. J. Invest. Dermatol. 118, 893-895. – reference: El-Ghorr, A. A. and M. Norval (1999) The UV waveband dependencies in mice differ for the suppression of contact hypersensitivity, delayed-type hypersensitivity and cis-urocanic acid formation. J. Invest. Dermatol. 112, 757-762. – reference: Steerenberg, P. A., F. Daamen, E. Weesendorp and H. Van Loveren (2006) No adaptation to UV-induced immunosuppression and DNA damage following exposure to mice to chronic UV-exposure. J. Photochem. Photobiol. B, Biol. 84, 28-37. – reference: Bykov, V. J., J. M. Sheehan, K. Hemminki and A. R. Young (1999) In situ repair of cyclobutane pyrimidine dimers and 6-4 photoproducts in human skin exposed to solar simulating radiation. J. Invest. Dermatol. 112, 326-331. – reference: Grimbaldeston, M. A., A. Simpson, J. J. Finlay-Jones and P. H. Hart (2003) The effect of ultraviolet radiation exposure on the prevalence of mast cells in human skin. Br. J. Dermatol. 148, 300-306. – reference: Ross, J. A., S. E. M. Howie, M. Norval, J. Maingay and T. J. Simpson (1986) Ultraviolet-irradiated urocanic acid suppresses delayed-type hypersensitivity to herpes simplex virus. J. Invest. Dermatol. 87, 630-633. – reference: Grimbaldeston, M. A., J. J. Finlay-Jones and P. H. Hart (2006) Mast cells in photodamaged skin: What is their role in skin cancer? Photochem. Photobiol. 5, 177-183. – reference: Hug, D. H. (2004) Association of nonmelanoma skin cancer with second malignancy. Cancer 101, 206-207. – reference: De Simone, C., C. Masini, M. S. Cattaruzza, C. Guerriero, D. Cerimele and M. Norval (2001) Urocanic acid isomers in patients with non-melanoma skin cancer. Br. J. Dermatol. 144, 858-861. – reference: Hart, P. H., M. A. Grimbaldeston, G. J. Swift, A. Jaksic, F. P. Noonan and J. J. Finlay-Jones (1998) Dermal mast cells determine susceptibility to UVB-induced systemic suppression of contact hypersensitivity. J. Exp. Med. 187, 2045-2053. – reference: Bech-Thomsen, N. and H. C. Wulf (1996) Photoprotection due to pigmentation and epidermal thickness after repeated exposure to ultraviolet light and psoralen plus ultraviolet A therapy. Photodermatol. Photoimmunol. Photomed. 11, 213-218. – reference: Meischer, G. (1930) Das problems des lichtchutzes und der lichtgewohnung. Strahlentherapie 35, 403-443. – reference: Czernielewski, J. M., I. Masouye, A. Pisani, J. Ferracin, D. Auvolat and J. P. Ortonne (1988) Effect of chronic sun exposure on human Langerhans cell density. Photodermatology 5, 116-120. – reference: Alcalay, J., J. N. Craig and M. L. Kripke (1989) Alterations in Langerhans cells and Thy-1+ dendritic epidermal cells in murine epidermis during the evolution of ultraviolet radiation-induced skin cancers. Cancer Res. 49, 4591-4596. – reference: Murphy, G. M., P. G. Norris, A. R. Young, M. F. Corbett and J. L. Hawk (1993) Low-dose ultraviolet-B irradiation depletes human epidermal Langerhans cells. Br. J. Dermatol. 129, 674-677. – reference: Cestari, T. F., M. L. Kripke, P. L. Baptista, L. Bakos and C. D. Bucana (1995) Ultraviolet radiation decreases the granulomatous response to lepromin in humans. J. Invest. Dermatol. 105, 8-13. – reference: Young, A. R., C. S. Potten, C. A. Chadwick, G. M. Murphy, J. L. Hawk and A. J. Cohen (1991) Photoprotection and 5-MOP photochemoprotection from UVR-induced DNA damage in humans: The role of skin type. J. Invest. Dermatol. 97, 942-948. – reference: Bataille, V., V. J. Bykov, P. Sasieni, S. Harulow, J. Cuzick and K. Hemminki (2000) Photoadaptation to ultraviolet (UV) radiation in vivo: Photoproducts in epidermal cells following UVB therapy for psoriasis. Br. J. Dermatol. 143, 477-483. – volume: 7 start-page: 223 year: 1997 end-page: 225 article-title: Immunosuppression induced by chronic solar‐simulated irradiation in humans and its prevention by sunscreens publication-title: Eur. J. Dermatol. – volume: 77 start-page: 394 year: 1992 end-page: 399 article-title: The effect of ultraviolet B irradiation and urocanic acid isomers on dendritic cell migration publication-title: Immunology – volume: 571 start-page: 185 year: 2005 end-page: 205 article-title: Mechanisms underlying UV‐induced immune suppression publication-title: Mutat. Res. – volume: 68 start-page: 738 year: 1998 end-page: 744 article-title: Suppression of delayed and contact hypersensitivity responses in mice have different UV dose responses publication-title: Photochem. Photobiol. – volume: 1 start-page: 227 year: 2006 end-page: 239 article-title: Photoimmunosuppression of contact hypersensitivity publication-title: Expert Rev. Dermatol. – volume: 32 start-page: 53 year: 1995 end-page: 62 article-title: Cumulative effects from repeated exposures to suberythemal doses of UVB and UVA in human skin publication-title: J. Am. Acad. Dermatol. – volume: 112 start-page: 939 year: 1999 end-page: 944 article-title: Low‐dose UVA and UVB have different time courses for suppression of contact hypersensitivity to a recall antigen in humans publication-title: J. Invest. Dermatol. – volume: 144 start-page: 858 year: 2001 end-page: 861 article-title: Urocanic acid isomers in patients with non‐melanoma skin cancer publication-title: Br. J. Dermatol. – volume: 119 start-page: 1204 year: 2002 end-page: 1206 article-title: Squamous cell carcinoma is not associated with high dermal mast cell prevalence in humans publication-title: J. Invest. Dermatol. – volume: 65 start-page: 862 year: 1997 end-page: 865 article-title: Urocanic acid concentration and photoisomerisation in Caucasian skin phototypes publication-title: Photochem. Photobiol. – volume: 11 start-page: 213 year: 1996 end-page: 218 article-title: Photoprotection due to pigmentation and epidermal thickness after repeated exposure to ultraviolet light and psoralen plus ultraviolet A therapy publication-title: Photodermatol. Photoimmunol. Photomed. – volume: 60 start-page: 429 year: 2004 end-page: 435 article-title: Exposure to low doses of solar‐simulated radiation induces an increase in the myeloid subtype of blood dendritic cells publication-title: Scand. J. Immunol. – volume: 12 start-page: 93 year: 1996 end-page: 99 article-title: The sunscreening effect of urocanic acid publication-title: Photodermatol. Photoimmunol. Photomed. – volume: 146 start-page: 1717 year: 1991 end-page: 1721 article-title: Antigen‐presenting activity of draining lymph node cells from mice painted with a contact allergen during ultraviolet carcinogenesis publication-title: J. Immunol. – volume: 45 start-page: 210 year: 2007 end-page: 212 article-title: Repeated exposures of humans to low doses of solar simulated radiation lead to limited photoadaptation and photoprotection against UVB‐induced erythema and cytokine mRNA up‐regulation publication-title: J. Dermatol. Sci. – volume: 77 start-page: 271 year: 2003 end-page: 275 article-title: Epidermal ‐urocanic acid levels correlate with lower specific cellular immune responses after hepatitis B vaccination of ultraviolet B‐exposed humans publication-title: Photochem. Photobiol. – volume: 24 start-page: 19 year: 2006 end-page: 25 article-title: Ultraviolet immunosuppression: Mechanisms and consequences publication-title: Dermatol. Clin. – volume: 118 start-page: 825 year: 2002 end-page: 829 article-title: Repeated ultraviolet exposure affords the same protection against DNA photodamage and erythema in human skin types II and IV but is associated with faster DNA repair in skin type IV publication-title: J. Invest. Dermatol. – volume: 54 start-page: 165 year: 2005 end-page: 171 article-title: Mechanisms of UV‐induced immunosuppression publication-title: Keio J. Med. – volume: 124 start-page: 1071 year: 2005 end-page: 1074 article-title: An action spectrum for the production of ‐urocanic acid in human skin in vivo publication-title: J. Invest. Dermatol. – volume: 32 start-page: 576 year: 1995 end-page: 583 article-title: Hyposensitization in nickel allergic contact dermatitis: Clinical and immunologic monitoring publication-title: J. Am. Acad. Dermatol. – volume: 79 start-page: 547 year: 2001 end-page: 568 article-title: Ultraviolet light induced injury: Immunological and inflammatory effects publication-title: Immunol. Cell Biol. – volume: 187 start-page: 2045 year: 1998 end-page: 2053 article-title: Dermal mast cells determine susceptibility to UVB‐induced systemic suppression of contact hypersensitivity publication-title: J. Exp. Med. – volume: 105 start-page: 8 year: 1995 end-page: 13 article-title: Ultraviolet radiation decreases the granulomatous response to lepromin in humans publication-title: J. Invest. Dermatol. – volume: 58 start-page: 285 year: 2005 end-page: 289 article-title: Mast cell distribution in normal adult skin publication-title: J. Clin. Pathol. – volume: 65 start-page: 573 year: 1999 end-page: 582 article-title: Systemic suppression of human peripheral blood phagocytic leukocytes after whole‐body UVB irradiation publication-title: J. Leukoc. Biol. – volume: 83 start-page: 254 year: 2003 end-page: 261 article-title: Enhanced ultraviolet responses in chronically sun‐exposed skin are dependent on previous sun exposure publication-title: Acta Derm. Venereol. – volume: 80 start-page: 81s issue: Suppl. year: 1983 end-page: 85s article-title: Chronologic and actinically induced aging in human facial skin publication-title: J. Invest. Dermatol. – volume: 81 start-page: 1168 year: 2005 end-page: 1173 article-title: Decrease in Langerhans cells and increase in lymph node dendritic cells following chronic exposure of mice to suberythemal doses of solar simulated radiation publication-title: Photochem. Photobiol. – volume: 11 start-page: 1 year: 1995 end-page: 5 article-title: Mast cells and elastosis in ultraviolet‐irradiated hairless mice publication-title: Photodermatol. Photoimmunol. Photomed. – volume: 63 start-page: 123 year: 1996 end-page: 127 article-title: Ultraviolet B radiation increases hairless mouse mast cells in a dose‐dependent manner and alters distribution of UV‐induced mast cell growth factor publication-title: Photochem. Photobiol. – volume: 97 start-page: 942 year: 1991 end-page: 948 article-title: Photoprotection and 5‐MOP photochemoprotection from UVR‐induced DNA damage in humans: The role of skin type publication-title: J. Invest. Dermatol. – volume: 112 start-page: 326 year: 1999 end-page: 331 article-title: In situ repair of cyclobutane pyrimidine dimers and 6‐4 photoproducts in human skin exposed to solar simulating radiation publication-title: J. Invest. Dermatol. – volume: 117 start-page: 1186 year: 2001 end-page: 1192 article-title: Broad‐spectrum sunscreens provide better protection from the suppression of the elicitation phase of delayed‐type hypersensitivity response in humans publication-title: J. Invest. Dermatol. – volume: 48 start-page: 42 year: 1999 end-page: 47 article-title: Isomerization of urocanic acid after ultraviolet radiation is influenced by skin pigmentation publication-title: J. Photochem. Photobiol. B, Biol. – volume: 84 start-page: 28 year: 2006 end-page: 37 article-title: No adaptation to UV‐induced immunosuppression and DNA damage following exposure to mice to chronic UV‐exposure publication-title: J. Photochem. Photobiol. B, Biol. – volume: 111 start-page: 982 year: 1998 end-page: 988 article-title: The similarity of action spectra for thymine dimers in human epidermis and erythema suggests that DNA is the chromophore for erythema publication-title: J. Invest. Dermatol. – volume: 71 start-page: 700 year: 2000 end-page: 705 article-title: The effect of suntan parlor exposure on delayed and contact hypersensitivity publication-title: Photochem. Photobiol. – volume: 101 start-page: 169 year: 1993 end-page: 174 article-title: Effect of phototherapy and urocanic acid isomers on natural killer cell function publication-title: J. Invest. Dermatol. – volume: 59 start-page: 1231 year: 1977 end-page: 1235 article-title: In vitro reactivity of macrophages and lymphocytes from ultraviolet‐irradiated mice publication-title: J. Natl Cancer Inst. – volume: 158 start-page: 84 year: 1983 end-page: 98 article-title: Mechanism of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology publication-title: J. Exp. Med. – volume: 129 start-page: 674 year: 1993 end-page: 677 article-title: Low‐dose ultraviolet‐B irradiation depletes human epidermal Langerhans cells publication-title: Br. J. Dermatol. – volume: 35 start-page: 403 year: 1930 end-page: 443 article-title: Das problems des lichtchutzes und der lichtgewohnung publication-title: Strahlentherapie – volume: 47 start-page: 129 year: 1998 end-page: 135 article-title: Differential effect of phototherapy on the activities of human natural killer cells and cytotoxic T cells publication-title: J. Photochem. Photobiol. B, Biol. – volume: 65 start-page: 101 year: 2001 end-page: 104 article-title: Biological consequences of cyclobutane pyrimidine dimers publication-title: J. Photochem. Photobiol. B, Biol. – volume: 16 start-page: 45 year: 2002 end-page: 53 article-title: Sunlight‐induced DNA damage in human mononuclear cells publication-title: FASEB J. – volume: 14 start-page: 104 year: 2001 end-page: 111 article-title: UVB irradiation suppresses cytokine production and innate cellular immune functions in mice publication-title: Cytokine – volume: 117 start-page: 678 year: 2001 end-page: 682 article-title: Solar‐simulated skin adaptation and its effect on subsequent UV‐induced epidermal DNA damage publication-title: J. Invest. Dermatol. – volume: 115 start-page: 317 year: 2000 end-page: 320 article-title: High dermal mast cell prevalence is a predisposing factor for basal cell carcinoma in humans publication-title: J. Invest. Dermatol. – volume: 107 start-page: 755 year: 1996 end-page: 763 article-title: Temporal correlation between UV radiation locally‐induced tolerance and the sequential appearance of dermal, then epidermal, class II MHC+CD11b+ monocytic/macrophagic cells publication-title: J. Invest. Dermatol. – volume: 118 start-page: 893 year: 2002 end-page: 895 article-title: Correlation analysis of production and photoisomerisation of epidermal urocanic acid versus induction and repair of DNA photoproducts in the human skin in situ publication-title: J. Invest. Dermatol. – volume: 5 start-page: 177 year: 2006 end-page: 183 article-title: Mast cells in photodamaged skin: What is their role in skin cancer? publication-title: Photochem. Photobiol. – volume: 4 start-page: 783 year: 2005 end-page: 788 article-title: Adaptation to the UV‐induced suppression of phagocytic activity in murine peritoneal macrophages following chronic exposure to solar simulated radiation publication-title: Photochem. Photobiol. Sci. – volume: 289 start-page: 501 year: 1997 end-page: 505 article-title: Urocanic acid isomers: Relation to body site, pigmentation, stratum corneum thickness and photosensitivity publication-title: Arch. Dermatol. Res. – volume: 49 start-page: 4591 year: 1989 end-page: 4596 article-title: Alterations in Langerhans cells and Thy‐1 dendritic epidermal cells in murine epidermis during the evolution of ultraviolet radiation‐induced skin cancers publication-title: Cancer Res. – volume: 90 start-page: 305 year: 1988 end-page: 310 article-title: Suppression of natural killer cell activity in humans by radiation from solarium lamps depleted of UVB publication-title: J. Invest. Dermatol. – volume: 148 start-page: 300 year: 2003 end-page: 306 article-title: The effect of ultraviolet radiation exposure on the prevalence of mast cells in human skin publication-title: Br. J. Dermatol. – volume: 110 start-page: 824 year: 1998 end-page: 827 article-title: Ultraviolet radiation induced suppression of Mantoux reactions in humans publication-title: J. Invest. Dermatol. – volume: 148 start-page: 224 year: 2003 end-page: 228 article-title: Pattern analysis of human cutaneous mast cell populations by total body surface mapping publication-title: Br. J. Dermatol. – volume: 150 start-page: 895 year: 2004 end-page: 903 article-title: Association between melanoma and dermal mast cell prevalence in sun‐unexposed skin publication-title: Br. J. Dermatol. – volume: 112 start-page: 757 year: 1999 end-page: 762 article-title: The UV waveband dependencies in mice differ for the suppression of contact hypersensitivity, delayed‐type hypersensitivity and ‐urocanic acid formation publication-title: J. Invest. Dermatol. – volume: 138 start-page: 986 year: 1998 end-page: 992 article-title: Urocanic acid isomers in patients with basal cell carcinoma and cutaneous malignant melanoma publication-title: Br. J. Dermatol. – volume: 57 start-page: 883 year: 1995 end-page: 890 article-title: Ultraviolet radiation reduces phagocytosis and intracellular killing of mycobacteria and inhibits nitric oxide production by macrophages in mice publication-title: J. Leukoc. Biol. – volume: 123 start-page: 965 year: 2004 end-page: 972 article-title: The time course of photoadaptation and pigmentation studied using a novel method to distinguish pigmentation from erythema publication-title: J. Invest. Dermatol. – volume: 73 start-page: 83 year: 2001 end-page: 89 article-title: Attenuation of DNA damage in the dermis and epidermis of the albino hairless mouse by chronic exposure to ultraviolet‐A and ‐B radiation publication-title: Photochem. Photobiol. – volume: 78 start-page: 633 year: 2003 end-page: 639 article-title: Susceptibility to basal cell carcinoma is associated with high dermal mast cell prevalence in non‐sun‐exposed skin for an Australian population publication-title: Photochem. Photobiol. – volume: 4 start-page: 517 year: 2005 end-page: 522 article-title: Suppression of contact hypersensitivity after repeated exposures of humans to low doses of solar simulated radiation publication-title: Photochem. Photobiol. Sci. – volume: 66 start-page: 290 year: 1986 end-page: 294 article-title: Local and systemic effect of ultraviolet irradiation (UVB and UVA) on human allergic contact dermatitis publication-title: Acta Derm. Venereol. – volume: 88 start-page: 271 year: 1987 end-page: 276 article-title: Analysis of the effect of a sunscreen agent on the suppression of natural killer cell activity induced in human subjects by radiation from solarium lamps publication-title: J. Invest. Dermatol. – volume: 150 start-page: 1729 year: 2005 end-page: 1743 article-title: Circulating leukocyte and cytokine responses to measles and poliovirus vaccination in children after ultraviolet radiation exposures publication-title: Arch. Virol. – volume: 87 start-page: 630 year: 1986 end-page: 633 article-title: Ultraviolet‐irradiated urocanic acid suppresses delayed‐type hypersensitivity to herpes simplex virus publication-title: J. Invest. Dermatol. – volume: 112 start-page: 13 year: 1999 end-page: 18 article-title: Adaptive antioxidant response of manganese‐superoxide dismutase following repetitive UVA irradiation publication-title: J. Invest. Dermatol. – volume: 4 start-page: 699 year: 2005 end-page: 798 article-title: Ultraviolet B radiation‐induced immunosuppression: Molecular mechanisms and cellular alterations publication-title: Photochem. Photobiol. Sci. – volume: 5 start-page: 116 year: 1988 end-page: 120 article-title: Effect of chronic sun exposure on human Langerhans cell density publication-title: Photodermatology – volume: 133 start-page: 728 year: 1995 end-page: 731 article-title: Urocanic acid isomers in human skin: Analysis of site variation publication-title: Br. J. Dermatol. – volume: 95 start-page: 73 year: 1994 end-page: 77 article-title: Long‐term ultraviolet B‐induced impairment of Langerhans cell function: An immunoelectron microscope study publication-title: Clin. Exp. Immunol. – volume: 56 start-page: 684 year: 1992 end-page: 690 article-title: Effect of β‐carotene supplementation on photosuppression of delayed‐type hypersensitivity in normal young men publication-title: Am. J. Clin. Nutr. – volume: 143 start-page: 477 year: 2000 end-page: 483 article-title: Photoadaptation to ultraviolet (UV) radiation : Photoproducts in epidermal cells following UVB therapy for psoriasis publication-title: Br. J. Dermatol. – volume: 105 start-page: 782 year: 1995 end-page: 788 article-title: In human dermis, ultraviolet radiation induces expansion of a CD36+ CD11b+ CD1‐ macrophage subset by infiltration and proliferation; CD1+ Langerhans‐like dendritic antigen‐presenting cells are concomitantly depleted publication-title: J. Invest. Dermatol. – volume: 66 start-page: 119 year: 1997 end-page: 123 article-title: Seasonal variation in urocanic acid isomers in human skin publication-title: Photochem. Photobiol. – volume: 79 start-page: 200 year: 1997 end-page: 203 article-title: Epidermal urocanic acid concentration and photoisomerization reactivity in patients with cutaneous malignant melanoma or basal cell carcinoma publication-title: Acta Derm. Venereol. – volume: 22 start-page: 67 year: 2006 end-page: 77 article-title: Biological effects of simulated ultraviolet daylight: A new approach to investigate daily photoprotection publication-title: Photodermatol. Photoimmunol. Photomed. – volume: 57 start-page: 123 year: 2000 end-page: 131 article-title: Differential effects of UVAI and UVB radiation on Langerhans cell migration in mice publication-title: J. Photochem. Photobiol. B, Biol. – volume: 116 start-page: 559 year: 1980 end-page: 561 article-title: Diminished immune responses in sun‐damaged skin publication-title: Arch. Dermatol. – volume: 101 start-page: 206 year: 2004 end-page: 207 article-title: Association of nonmelanoma skin cancer with second malignancy publication-title: Cancer – volume: 8 start-page: 195 year: 1991 end-page: 199 article-title: Numbers of murine mast cells remain unchanged during chronic ultraviolet B irradiation publication-title: Photodermatol. Photoimmunol. Photomed. – ident: e_1_2_6_54_2 doi: 10.1007/s00705-005-0561-6 – ident: e_1_2_6_74_2 doi: 10.1111/j.1751-1097.1998.tb02538.x – ident: e_1_2_6_29_2 doi: 10.1111/1523-1747.ep12456257 – volume: 49 start-page: 4591 year: 1989 ident: e_1_2_6_38_2 article-title: Alterations in Langerhans cells and Thy‐1+ dendritic epidermal cells in murine epidermis during the evolution of ultraviolet radiation‐induced skin cancers publication-title: Cancer Res. – ident: e_1_2_6_4_2 doi: 10.1016/j.mrfmmm.2004.06.059 – ident: e_1_2_6_20_2 doi: 10.1016/j.jdermsci.2006.11.001 – ident: e_1_2_6_32_2 doi: 10.1046/j.1523-1747.2002.16602.x – ident: e_1_2_6_63_2 doi: 10.1084/jem.187.12.2045 – ident: e_1_2_6_23_2 doi: 10.1111/j.0022-202X.2005.23731.x – ident: e_1_2_6_26_2 doi: 10.1002/cncr.20346 – ident: e_1_2_6_55_2 doi: 10.1111/1523-1747.ep12365802 – ident: e_1_2_6_77_2 doi: 10.1016/0190-9622(95)90340-2 – ident: e_1_2_6_7_2 doi: 10.1586/17469872.1.2.227 – ident: e_1_2_6_37_2 doi: 10.1046/j.1365-2133.2001.04145.x – volume: 5 start-page: 116 year: 1988 ident: e_1_2_6_42_2 article-title: Effect of chronic sun exposure on human Langerhans cell density publication-title: Photodermatology – ident: e_1_2_6_70_2 doi: 10.1111/j.1365-2133.2004.05966.x – ident: e_1_2_6_33_2 doi: 10.1562/0031-8655(2003)0770271ECUALC2.0.CO2 – ident: e_1_2_6_45_2 doi: 10.1111/j.1365-2133.1993.tb03330.x – ident: e_1_2_6_76_2 doi: 10.1039/b503166d – ident: e_1_2_6_86_2 doi: 10.1111/1523-1747.ep12312309 – ident: e_1_2_6_25_2 doi: 10.1007/s004030050230 – ident: e_1_2_6_59_2 doi: 10.1006/cyto.2001.0849 – ident: e_1_2_6_69_2 doi: 10.1136/jcp.2004.017210 – ident: e_1_2_6_18_2 doi: 10.1046/j.0022-202x.2001.01478.x – ident: e_1_2_6_65_2 doi: 10.1111/j.1600-0781.1995.tb00128.x – ident: e_1_2_6_22_2 doi: 10.1096/fj.01-0386com – ident: e_1_2_6_43_2 doi: 10.1016/0190-9622(95)90184-1 – volume: 8 start-page: 195 year: 1991 ident: e_1_2_6_66_2 article-title: Numbers of murine mast cells remain unchanged during chronic ultraviolet B irradiation publication-title: Photodermatol. Photoimmunol. Photomed. – ident: e_1_2_6_2_2 doi: 10.1046/j.1440-1711.2001.01047.x – volume: 59 start-page: 1231 year: 1977 ident: e_1_2_6_60_2 article-title: In vitro reactivity of macrophages and lymphocytes from ultraviolet‐irradiated mice publication-title: J. Natl Cancer Inst. doi: 10.1093/jnci/59.4.1231 – ident: e_1_2_6_49_2 doi: 10.1111/1523-1747.ep12466123 – ident: e_1_2_6_31_2 doi: 10.1016/S1011-1344(99)00007-X – ident: e_1_2_6_30_2 doi: 10.1111/j.1751-1097.1997.tb01935.x – volume: 7 start-page: 223 year: 1997 ident: e_1_2_6_83_2 article-title: Immunosuppression induced by chronic solar‐simulated irradiation in humans and its prevention by sunscreens publication-title: Eur. J. Dermatol. – ident: e_1_2_6_68_2 doi: 10.1046/j.1365-2133.2003.05090.x – ident: e_1_2_6_79_2 doi: 10.1046/j.1523-1747.1999.00610.x – volume: 35 start-page: 403 year: 1930 ident: e_1_2_6_9_2 article-title: Das problems des lichtchutzes und der lichtgewohnung publication-title: Strahlentherapie – ident: e_1_2_6_13_2 doi: 10.1016/S1011-1344(01)00245-7 – ident: e_1_2_6_71_2 doi: 10.1562/0031-8655(2003)0780633STBCCI2.0.CO2 – ident: e_1_2_6_12_2 doi: 10.1046/j.1523-1747.1999.00465.x – ident: e_1_2_6_3_2 doi: 10.2302/kjm.54.165 – ident: e_1_2_6_84_2 doi: 10.1046/j.0022-202x.2001.01545.x – ident: e_1_2_6_16_2 doi: 10.1046/j.1523-1747.1999.00523.x – ident: e_1_2_6_58_2 doi: 10.1002/jlb.57.6.883 – ident: e_1_2_6_10_2 doi: 10.1111/1523-1747.ep12491807 – ident: e_1_2_6_35_2 doi: 10.1080/000155599750010968 – ident: e_1_2_6_24_2 doi: 10.1111/j.1365-2133.1995.tb02746.x – ident: e_1_2_6_19_2 doi: 10.1080/00015550310016481 – ident: e_1_2_6_8_2 doi: 10.1111/j.0022-202X.2004.23464.x – ident: e_1_2_6_56_2 doi: 10.1111/1523-1747.ep12326032 – ident: e_1_2_6_62_2 doi: 10.1039/b504344a – ident: e_1_2_6_67_2 doi: 10.1046/j.1365-2133.2003.05113.x – ident: e_1_2_6_14_2 doi: 10.1046/j.1523-1747.1998.00436.x – ident: e_1_2_6_46_2 doi: 10.1562/2005-04-10-RA-484 – ident: e_1_2_6_61_2 doi: 10.1039/b503094c – ident: e_1_2_6_85_2 doi: 10.1046/j.1523-1747.1998.00176.x – ident: e_1_2_6_52_2 doi: 10.1016/S1011-1344(98)00211-5 – ident: e_1_2_6_17_2 doi: 10.1111/j.1600-0781.1995.tb00172.x – volume: 77 start-page: 394 year: 1992 ident: e_1_2_6_39_2 article-title: The effect of ultraviolet B irradiation and urocanic acid isomers on dendritic cell migration publication-title: Immunology – ident: e_1_2_6_5_2 doi: 10.1039/b418378a – volume: 12 start-page: 93 year: 1996 ident: e_1_2_6_27_2 article-title: The sunscreening effect of urocanic acid publication-title: Photodermatol. Photoimmunol. Photomed. – ident: e_1_2_6_48_2 doi: 10.1111/j.0300-9475.2004.01489.x – ident: e_1_2_6_50_2 doi: 10.1111/1523-1747.ep12456090 – volume: 146 start-page: 1717 year: 1991 ident: e_1_2_6_80_2 article-title: Antigen‐presenting activity of draining lymph node cells from mice painted with a contact allergen during ultraviolet carcinogenesis publication-title: J. Immunol. doi: 10.4049/jimmunol.146.6.1717 – volume: 80 start-page: 81s year: 1983 ident: e_1_2_6_41_2 article-title: Chronologic and actinically induced aging in human facial skin publication-title: J. Invest. Dermatol. doi: 10.1038/jid.1983.20 – volume: 116 start-page: 559 year: 1980 ident: e_1_2_6_87_2 article-title: Diminished immune responses in sun‐damaged skin publication-title: Arch. Dermatol. doi: 10.1001/archderm.1980.01640290069015 – ident: e_1_2_6_73_2 doi: 10.1046/j.1523-1747.2002.19511.x – volume: 66 start-page: 290 year: 1986 ident: e_1_2_6_78_2 article-title: Local and systemic effect of ultraviolet irradiation (UVB and UVA) on human allergic contact dermatitis publication-title: Acta Derm. Venereol. doi: 10.2340/0001555566290294 – ident: e_1_2_6_75_2 doi: 10.1046/j.1523-1747.1999.00565.x – ident: e_1_2_6_6_2 doi: 10.1016/j.det.2005.08.003 – ident: e_1_2_6_15_2 doi: 10.1111/j.1365-2133.2000.03698.x – ident: e_1_2_6_21_2 doi: 10.1562/0031-8655(2001)0730083AODDIT2.0.CO2 – ident: e_1_2_6_53_2 doi: 10.1562/0031-8655(2000)0710700TEOSPE2.0.CO2 – ident: e_1_2_6_57_2 doi: 10.1002/jlb.65.5.573 – ident: e_1_2_6_36_2 doi: 10.1046/j.1365-2133.1998.02264.x – ident: e_1_2_6_44_2 doi: 10.1111/j.1600-0781.2006.00209.x – ident: e_1_2_6_82_2 doi: 10.1093/ajcn/56.4.684 – ident: e_1_2_6_40_2 doi: 10.1016/S1011-1344(00)00087-7 – ident: e_1_2_6_72_2 doi: 10.1046/j.1523-1747.2000.00050.x – ident: e_1_2_6_81_2 doi: 10.1016/j.jphotobiol.2006.01.009 – ident: e_1_2_6_28_2 doi: 10.1084/jem.158.1.84 – ident: e_1_2_6_34_2 doi: 10.1111/j.1751-1097.1997.tb03147.x – ident: e_1_2_6_64_2 doi: 10.1111/j.1751-1097.1996.tb03002.x – ident: e_1_2_6_47_2 doi: 10.1111/j.1365-2249.1994.tb06017.x – ident: e_1_2_6_51_2 doi: 10.1111/1523-1747.ep12363652 – ident: e_1_2_6_11_2 doi: 10.1046/j.1523-1747.2002.01681.x |
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| Snippet | A single or a limited number of UVR exposures is recognized to suppress cell‐mediated immunity in human subjects. The complex pathway leading from the... A single or a limited number of UVR exposures is recognized to suppress cell-mediated immunity in human subjects. The complex pathway leading from the... AbstractA single or a limited number of UVR exposures is recognized to suppress cell-mediated immunity in human subjects. The complex pathway leading from the... |
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| SubjectTerms | Air pollution Animals Antigen presentation Cells Chromosomes - genetics Chromosomes - immunology Chromosomes - radiation effects Deoxyribonucleic acid DNA DNA damage DNA repair Genetic diversity Human subjects Humans Hypersensitivity Hypersensitivity - immunology Immune system Immune System - immunology Immune System - radiation effects Infectious diseases Light therapy Time Factors Ultraviolet radiation Ultraviolet Rays - adverse effects |
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| Title | The Effect of Chronic Ultraviolet Radiation on the Human Immune System |
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