c‐IAP ubiquitin protein ligase activity is required for 4‐1BB signaling and CD8+ memory T‐cell survival

• Published in: European journal of immunology Vol. 45; no. 9; pp. 2672 - 2682
• Main Authors: Giardino Torchia, Maria Letizia, Munitic, Ivana, Castro, Ehydel, Herz, Jasmin, McGavern, Dorian B., Ashwell, Jonathan D.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.09.2015
• Subjects: 4‐1BB; Adoptive Transfer; Animals; Antibodies, Monoclonal - pharmacology; Apoptosis - genetics; Apoptosis - immunology; Baculoviral IAP Repeat-Containing 3 Protein; CD8+ memory T cell; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - pathology; CD8-Positive T-Lymphocytes - transplantation; CD8-Positive T-Lymphocytes - virology; Cell Survival - genetics; Cell Survival - immunology; Cells, Cultured; Female; Gene Expression Regulation; Immunologic Memory - genetics; Inhibitor of Apoptosis Proteins - genetics; Inhibitor of Apoptosis Proteins - immunology; Inhibitor of Apoptosis Proteins - metabolism; Lymphocyte Activation - drug effects; Lymphocyte Count; Lymphocytes; Lymphocytic Choriomeningitis - genetics; Lymphocytic Choriomeningitis - immunology; Lymphocytic Choriomeningitis - pathology; Lymphocytic Choriomeningitis - virology; lymphocytic choriomeningitis virus; Lymphocytic choriomeningitis virus - immunology; Mice; Mice, Transgenic; Mutation; NF-kappa B - genetics; NF-kappa B - immunology; Rodents; Signal Transduction; T cell receptors; Tumor Necrosis Factor Receptor Superfamily, Member 9 - antagonists & inhibitors; Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics; Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology; T‐cell memory; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - immunology; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; CD8+ memory T cell; Signal transduction; 4-1BB; Ubiquitination; lymphocytic choriomeningitis virus; T-cell memory

Cellular inhibitor of apoptosis proteins (c‐IAP) 1 and 2 are widely expressed ubiquitin protein ligases that regulate a variety of cellular functions, including the sensitivity of T cells to costimulation. 4‐1BB is a TNF receptor family member that signals via a complex that includes TRAF family mem...