Increased plasma chemokine levels in children with Prader-Willi syndrome

• Published in: American journal of medical genetics. Part A Vol. 167A; no. 3; pp. 563 - 571
• Main Authors: Butler, Merlin G., Hossain, Waheeda, Sulsona, Carlos, Driscoll, Daniel J., Manzardo, Ann M.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.03.2015; Wiley Subscription Services, Inc
• Subjects: bioinflammatory chemokines; Chemokines - blood; Child; Child, Preschool; children; cytokines; Cytokines - blood; Female; Genetic Testing; Humans; immune system; Male; neurodevelopment; Phenotype; Prader-Willi syndrome; Prader-Willi Syndrome - blood; Prader-Willi Syndrome - diagnosis; Prader-Willi Syndrome - genetics; Siblings; bioinflammatory chemokines; immune system; cytokines; Prader-Willi syndrome; neurodevelopment; children

Prader–Willi syndrome (PWS) is caused by loss of paternally expressed genes from the 15q11‐q13 region and reportedly rearranged as a cause of autism. Additionally, increased inflammatory markers and features of autism are reported in PWS. Cytokines encoded by genes involved with inflammation, cell p...