co-activator of nitrogen-regulated transcription in Saccharomyces cerevisiae

• Published in: Molecular microbiology Vol. 31; no. 3; pp. 753 - 762
• Main Authors: Soussi-Boudekou, S, Andre, B
• Format: Journal Article
• Language: English
• Published: Oxford BSL Blackwell Science Ltd 01.02.1999; Blackwell Publishing Ltd
• Subjects: Adaptor Proteins, Signal Transducing; analysis; beta-Galactosidase; beta-Galactosidase - analysis; Cell Cycle Proteins; DNA-Binding Proteins; DNA-Binding Proteins - genetics; Epistasis, Genetic; Fungal Proteins; Fungal Proteins - genetics; Gene Deletion; Gene Expression Regulation, Fungal; genetics; Glutamate Dehydrogenase (NADP+); Glutamate Dehydrogenase (NADP+) - metabolism; Glutamate-Ammonia Ligase; Glutamate-Ammonia Ligase - analysis; Glutamic Acid; Glutamic Acid - analysis; Histone Acetyltransferases; Lac Operon; metabolism; Nitrogen; Nitrogen - metabolism; Nitrogen - pharmacology; nitrogen catabolite repression; p300-CBP Transcription Factors; pharmacology; Plant Proteins; Plant Proteins - genetics; Proline; Proline - analysis; Quaternary Ammonium Compounds; Quaternary Ammonium Compounds - analysis; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae Proteins; Trans-Activators; Trans-Activators - genetics; transcription (genetics); Transcription Factors; Transcription, Genetic

In Saccharomyces cerevisiae, the transcription factors Gln3p and Nil1p of the GATA family play a determinant role in expression of genes that are subject to nitrogen catabolite repression. Here we report the isolation of a new yeast mutant, gan1‐1, exhibiting dramatically decreased NAD‐linked glutam...