Folic acid and orofacial clefts: a review of the evidence
Orofacial clefts are common and burdensome birth defects with a complex genetic and environmental etiology. The contribution of nutritional factors and supplements to the etiology of orofacial clefts has long been theorized and studied. Multiple studies have evaluated the role of folic acid in the o...
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| Published in | Oral diseases Vol. 16; no. 1; pp. 11 - 19 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.01.2010
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Orofacial clefts are common and burdensome birth defects with a complex genetic and environmental etiology. The contribution of nutritional factors and supplements to the etiology of orofacial clefts has long been theorized and studied. Multiple studies have evaluated the role of folic acid in the occurrence and recurrence of orofacial clefts, using observational and non‐randomized interventional designs. While preventive effects of folic acid on orofacial clefts are commonly reported, the evidence remains generally inconsistent. This paper reviews the findings of the main studies of the effects of folic acid on orofacial clefts, summarizes study limitations, and discusses research needs with a focus on studying the effects of high dosage folic acid on the recurrence of oral clefts using a randomized clinical trial design. The role of folic acid in the prevention of neural tube defects is also briefly summarized and discussed as a reference model for orofacial clefts. |
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| AbstractList | Orofacial clefts are common and burdensome birth defects with a complex genetic and environmental etiology. The contribution of nutritional factors and supplements to the etiology of orofacial clefts has long been theorized and studied. Multiple studies have evaluated the role of folic acid in the occurrence and recurrence of orofacial clefts, using observational and non‐randomized interventional designs. While preventive effects of folic acid on orofacial clefts are commonly reported, the evidence remains generally inconsistent. This paper reviews the findings of the main studies of the effects of folic acid on orofacial clefts, summarizes study limitations, and discusses research needs with a focus on studying the effects of high dosage folic acid on the recurrence of oral clefts using a randomized clinical trial design. The role of folic acid in the prevention of neural tube defects is also briefly summarized and discussed as a reference model for orofacial clefts. Orofacial clefts are common and burdensome birth defects with a complex genetic and environmental etiology. The contribution of nutritional factors and supplements to the etiology of orofacial clefts has long been theorized and studied. Multiple studies have evaluated the role of folic acid in the occurrence and recurrence of orofacial clefts, using observational and non-randomized interventional designs. While preventive effects of folic acid on orofacial clefts are commonly reported, the evidence remains generally inconsistent. This paper reviews the findings of the main studies of the effects of folic acid on orofacial clefts, summarize study limitations, and discuss research needs with a focus on studying the effects of high dosage folic acid on the recurrence of oral clefts using a randomized clinical trial design. The role of folic acid in the prevention of neural tube defects is also briefly summarized and discussed as a reference model for orofacial clefts. |
| Author | Murray, JC Wehby, GL |
| Author_xml | – sequence: 1 givenname: GL surname: Wehby fullname: Wehby, GL organization: Department of Health Management and Policy, College of Public Health, University of Iowa, Iowa City, IA 52242 – sequence: 2 givenname: JC surname: Murray fullname: Murray, JC organization: University of Iowa, Div of Neonatology, Dept of Pediatrics, Iowa City, IA 52242, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20331806$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | cleft lip Cleft Lip - genetics Cleft Lip - prevention & control Cleft Palate - genetics Cleft Palate - prevention & control Clinical Trials as Topic folate folic acid Folic Acid - therapeutic use Gene Expression Regulation, Developmental Humans Neural Tube Defects - prevention & control Orofacial clefts prevention randomized clinical trials Vitamin B Complex - therapeutic use |
| Title | Folic acid and orofacial clefts: a review of the evidence |
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