Analysis of hyperalgesia time courses in humans after painful electrical high-frequency stimulation identifies a possible transition from early to late LTP-like pain plasticity

• Published in: Pain (Amsterdam) Vol. 152; no. 7; pp. 1532 - 1539
• Main Authors: Pfau, Doreen B., Klein, Thomas, Putzer, Daniel, Pogatzki-Zahn, Esther M., Treede, Rolf-Detlef, Magerl, Walter
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier B.V 01.07.2011; Lippincott Williams & Wilkins, Inc; Elsevier
• Subjects: Adult; Biological and medical sciences; Biophysical Phenomena; Central sensitization; Chronic pain; Early LTP; Electric Stimulation - adverse effects; Female; Fundamental and applied biological sciences. Psychology; Humans; Hyperalgesia - physiopathology; Illness and personality; Illness, stress and coping; Late LTP; Likelihood Functions; Long-term potentiation; Long-Term Potentiation - physiology; LTP; LTP1; LTP2; Male; Pain Measurement; Pain Threshold - physiology; Persistent pain; Psychology and medicine; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Secondary hyperalgesia; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors; Statistics as Topic; Time Factors; Vertebrates: nervous system and sense organs; Young Adult; Secondary hyperalgesia; Early LTP; Long-term potentiation; Central sensitization; Late LTP; LTP; LTP2; LTP1; Persistent pain; Chronic pain; Allodynia; Human; Potentiation; Sensation; Electrical stimulus; Recovery; Electrodes; Pain; Synaptic plasticity; Skin; Sensitization; High frequency; Time analysis

Electrical high-frequency stimulation (HFS) of skin afferents elicits long-term potentiation (LTP)-like hyperalgesia in humans. Time courses were evaluated in the facilitating (homotopic) or facilitated (heterotopic) pathways to delineate the relative contributions of early or late LTP-like pain pla...