Docosahexaenoic acid,22:6n-3: Its roles in the structure and function of the brain

• Published in: International journal of developmental neuroscience Vol. 79; no. 1; pp. 21 - 31
• Main Authors: Mallick, Rahul, Basak, Sanjay, Duttaroy, Asim K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.12.2019; Elsevier BV
• Subjects: Aging; Aging - metabolism; Alzheimer's disease; Animals; Apoptosis; Attention deficit hyperactivity disorder; Bipolar disorder; Brain; Brain - metabolism; Brain development; Brain Diseases - metabolism; Brain disorders; Calcium homeostasis; Calcium ions; Clinical trials; Cognition; Cognition - physiology; Cognitive; Cognitive ability; DHA uptake; Diet; Dietary supplements; Disorders; Docosahexaenoic acid; Docosahexaenoic acid,22:6n-3; Docosahexaenoic Acids - metabolism; Endocannabinoid system; Epidemiology; FABPs; Fatty acids; Fatty Acids - metabolism; Fetuses; Fish oils; Functional anatomy; Homeostasis; Humans; Impulsive behavior; Infants; Life cycles; Maintenance; Marine oil; Mental disorders; Metabolites; Neurodegenerative diseases; Neurogenesis; Neurogenesis - physiology; Nutrient cycles; Pain perception; Quality of life; Resolvins; Schizophrenia; ADHD; NO; Brain disorders; Docosahexaenoic acid,22:6n-3; Brain development; Clinical trials; NPD1; RXR; Neurogenesis; B-FABP; FAHFA; FADS2; Endocannabinoid system; PPAR; Resolvins; H-FABP; Marine oil; DHA uptake; Cognitive; APOE; CYP; PPAR-α; PPAR-γ; AA; p-FABPpm; EDPs; AD; HDoHE; FABP; EFOX; GPRs; COX; LCPUFA; FABPs; LOX; ALA; EPA; MaR1; HPA; PEMT; DHA; PUFAs; HpDHA

•Docosahexaenoic acid,22:6n-3 (DHA) is important for brain growth and development.•Dietary intake of DHA is recommended throughout the life cycle.•DHA and its metabolites are involved in the brain structure and function.•DHA deficiency is observed in brain disorders.•Clinical trials of DHA supplemen...