Flash Chemistry: Fast Chemical Synthesis by Using Microreactors

• Published in: Chemistry : a European journal Vol. 14; no. 25; pp. 7450 - 7459
• Main Authors: Yoshida, Jun-ichi, Nagaki, Aiichiro, Yamada, Takeshi
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.01.2008; WILEY‐VCH Verlag
• Subjects: green chemistry; microreactors; polymerization; synthetic methods
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.200800582

This concept article provides a brief outline of the concept of flash chemistry for carrying out extremely fast reactions in organic synthesis by using microreactors. Generation of highly reactive species is one of the key elements of flash chemistry. Another important element of flash chemistry is the control of extremely fast reactions to obtain the desired products selectively. Fast reactions are usually highly exothermic, and heat removal is an important factor in controlling such reactions. Heat transfer occurs very rapidly in microreactors by virtue of a large surface area per unit volume, making precise temperature control possible. Fast reactions often involve highly unstable intermediates, which decompose very quickly, making reaction control difficult. The residence time can be greatly reduced in microreactors, and this feature is quite effective in controlling such reactions. For extremely fast reactions, kinetics often cannot be used because of the lack of homogeneity of the reaction environment when they are conducted in conventional reactors such as flasks. Fast mixing using micromixers solves such problems. The concept of flash chemistry has been successfully applied to various organic reactions including a) highly exothermic reactions that are difficult to control in conventional reactors, b) reactions in which a reactive intermediate easily decomposes in conventional reactors, c) reactions in which undesired byproducts are produced in the subsequent reactions in conventional reactors, and d) reactions whose products easily decompose in conventional reactors. The concept of flash chemistry can be also applied to polymer synthesis. Cationic polymerization can be conducted with an excellent level of molecular‐weight control and molecular‐weight distribution control. Speedy reaction: Flash chemistry is defined as a field of chemical synthesis in which extremely fast reactions are conducted in a highly controlled manner to produce desired compounds with high selectivity. This article provides a brief outline of the concept of flash chemistry using microreactors and its applications to organic synthesis and polymer synthesis.