HP1γ binding pre-mRNA intronic repeats modulates RNA splicing decisions

• Published in: EMBO reports Vol. 22; no. 9; pp. e52320 - n/a
• Main Authors: Rachez, Christophe, Legendre, Rachel, Costallat, Mickaël, Varet, Hugo, Yi, Jia, Kornobis, Etienne, Muchardt, Christian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.09.2021; Springer Nature B.V; EMBO Press; John Wiley and Sons Inc
• Subjects: Alternative splicing; Binding; Cbx3; Chromatin; DNA-directed RNA polymerase; EMBO09; EMBO36; Enrichment; Exons; Gene silencing; Genomes; Heterochromatin; HP1; Introns; Life Sciences; Proteins; Ribonucleic acid; RNA; RNA polymerase; RNA polymerase II; Splice junctions; Splicing; Transcription; HP1; splicing; RNA; chromatin; Cbx3; splicing Subject Categories Chromatin; Transcription & Genomics; RNA Biology

HP1 proteins are best known as markers of heterochromatin and gene silencing. Yet, they are also RNA-binding proteins and the HP1γ/CBX3 family member is present on transcribed genes together with RNA polymerase II, where it regulates co-transcriptional processes such as alternative splicing. To gain...