The Antileukemia Activity of Natural Product HQ17(3) Is Possibly Associated with Downregulation of miR-17-92 Cluster

• Published in: BioMed research international Vol. 2014; no. 2014; pp. 1 - 6
• Main Authors: Liao, Ya-Chun, Lin, Tzu-Heng, Chen, Chih-Ying, Lin, Shwu-Bin, Au, Lo-Chun
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Puplishing Corporation 01.01.2014; Hindawi Publishing Corporation; John Wiley & Sons, Inc
• Subjects: Antigens, Neoplasm; Antimitotic agents; Antineoplastic agents; Apoptosis; Binding sites; Biotechnology; Cancer; Care and treatment; Cell Line, Tumor; DNA Topoisomerases, Type II; DNA-Binding Proteins - antagonists & inhibitors; Drug dosages; Fluorouracil - administration & dosage; Gene Expression Regulation, Leukemic - drug effects; Humans; Hydroquinones - administration & dosage; Leukemia; Leukemia - drug therapy; Leukemia - genetics; Leukemia - pathology; Lymphoma; Medical research; Medicinal plants; Medicine, Experimental; MicroRNA; MicroRNAs - biosynthesis; Proteins; Proto-Oncogene Proteins c-myc - genetics; Proto-Oncogene Proteins c-myc - metabolism; Rhus; Tumorigenesis

The compound 10′(Z),13′(E),15′(E)-heptadecatrienylhydroquinone [HQ17(3)] was purified from the sap of the lacquer tree Rhus succedanea. HQ17(3) has cytotoxic effect on cancer cells and can inhibit topoisomerase (topo) IIα activity. We treated various cancer cells with different doses of HQ17(3) and...