Differential Analysis of Key Proteins Related to Fibrosis and Inflammation in Soluble Egg Antigen of Schistosoma mansoni at Different Infection Times

• Published in: Pathogens (Basel) Vol. 12; no. 3; p. 441
• Main Authors: Chen, Ying-Chou, Chen, I-An, Peng, Shih-Yi, Cheng, Po-Ching
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.03.2023; MDPI
• Subjects: 14-3-3 protein; Antigens; Bladder; Cell activation; Chemokines; Chronic infection; coculture; Collagen; Cytokines; Eggs; Fibrosis; Gene expression; Global health; Granulomas; Heat shock proteins; heat stress; hepatic stellate cells; Immune response; Immune system; Infections; Inflammation; Kinases; Laboratory animals; Liver; liver cirrhosis; liver fibrosis; Mass spectrometry; Mass spectroscopy; Matrilysin; Parasites; PBMCs; Peripheral blood mononuclear cells; Phosphorylation; phosphotransferases (kinases); Proteins; Public health; Schistosoma mansoni; Schistosoma mansoni; Schistosomiasis; Scientific imaging; secretion; Soluble egg antigen; Transforming growth factor-b; Tropical diseases; mass spectrometry; hepatic stellate cells; liver fibrosis; Schistosoma mansoni; PBMCs; soluble egg antigen

Schistosomiasis is a major global health problem. Schistosomes secrete antigens into the host tissue that bind to chemokines or inhibit immune cell receptors, regulating the immune responses to allow schistosome development. However, the detailed mechanism of chronic schistosome infection-induced li...