Osteoblast-Specific Overexpression of Human WNT16 Increases Both Cortical and Trabecular Bone Mass and Structure in Mice

• Published in: Endocrinology (Philadelphia) Vol. 157; no. 2; pp. 722 - 736
• Main Authors: Alam, Imranul, Alkhouli, Mohammed, Gerard-O'Riley, Rita L, Wright, Weston B, Acton, Dena, Gray, Amie K, Patel, Bhavmik, Reilly, Austin M, Lim, Kyung-Eun, Robling, Alexander G, Econs, Michael J
• Format: Journal Article
• Language: English
• Published: United States Endocrine Society 01.02.2016
• Subjects: Acid Phosphatase - genetics; Acid Phosphatase - metabolism; Alkaline Phosphatase - genetics; Alkaline Phosphatase - metabolism; Animals; Bone and Bones - diagnostic imaging; Bone Density - genetics; Collagen Type I - genetics; Collagen Type I - metabolism; Female; Femur - diagnostic imaging; Femur - metabolism; Humans; Isoenzymes - genetics; Isoenzymes - metabolism; Male; Mice; Mice, Transgenic; Original Research; Osteoblasts - metabolism; Osteocalcin - genetics; Osteocalcin - metabolism; Osteogenesis - genetics; Osteoporosis; Osteoprotegerin - genetics; Osteoprotegerin - metabolism; Peptides - genetics; Peptides - metabolism; RANK Ligand - genetics; RANK Ligand - metabolism; Real-Time Polymerase Chain Reaction; Retroviridae; RNA, Messenger - metabolism; Tartrate-Resistant Acid Phosphatase; Wnt Proteins - genetics; Wnt Signaling Pathway; X-Ray Microtomography

Previous genome-wide association studies have identified common variants in genes associated with bone mineral density (BMD) and risk of fracture. Recently, we identified single nucleotide polymorphisms (SNPs) in Wingless-type mouse mammary tumor virus integration site (WNT)16 that were associated w...