Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes

• Published in: Journal of allergy and clinical immunology Vol. 131; no. 4; pp. 1117 - 1129.e5
• Main Authors: Chan, Yvonne R., Chen, Kong, Duncan, Steven R., Lathrop, Kira L., Latoche, Joseph D., Logar, Alison J., Pociask, Derek A., Wahlberg, Brendon J., Ray, Prabir, Ray, Anuradha, Pilewski, Joseph M., Kolls, Jay K.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.04.2013; Elsevier; Elsevier Limited
• Subjects: Adult; Aged; Allergy and Immunology; animal models; Antigens; Antigens, Bacterial - immunology; Antigens, Bacterial - pharmacology; Antigens, Fungal - immunology; Antigens, Fungal - pharmacology; Aspergillus; Aspergillus - chemistry; Aspergillus species; autoimmune diseases; Biological and medical sciences; Case-Control Studies; Cell Proliferation - drug effects; chronic infectious disease; Chronic obstructive pulmonary disease; Cystic fibrosis; Cystic Fibrosis - genetics; Cystic Fibrosis - immunology; Cystic Fibrosis - pathology; Disease; Errors of metabolism; Female; flow cytometry; fluorescent antibody technique; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Fungal infections; Gene Expression; human diseases; Human subjects; Humans; IL-17; IL-22; Immune system; immunity; Immunologic Memory; Immunopathology; Immunophenotyping; interleukin-17; Interleukin-17 - genetics; Interleukin-17 - immunology; Interleukin-22; Interleukins - genetics; Interleukins - immunology; Lung - drug effects; Lung - immunology; Lung - pathology; lung transplant; Lungs; lymph nodes; Lymph Nodes - drug effects; Lymph Nodes - immunology; Lymph Nodes - pathology; Lymphocyte Activation - drug effects; Male; Medical sciences; memory T-cell response; Metabolic diseases; Middle Aged; Miscellaneous hereditary metabolic disorders; organ transplantation; pathogens; patients; phenotype; Pseudomonas aeruginosa; Pseudomonas aeruginosa - chemistry; Pseudomonas species; quantitative polymerase chain reaction; Review boards; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Studies; T-lymphocytes; TH17; Th17 Cells - drug effects; Th17 Cells - immunology; Th17 Cells - pathology; TH22; Transplants & implants; memory T-cell response; CORE; TCR; CF; Aspergillus species; lung transplant; Pa(EL); PLC; Con A; DLN; IL-22; TH22; ROR; cystic fibrosis; IL-17; Pseudomonas species; chronic infectious disease; TH17; NK; Asp; COPD; Pa(LL); Parenchymal lung leukocyte; Center for Organ Recovery and Education; Pseudomonas aeruginosa late log-phase filtrate antigen; T H17; T-cell receptor; T H22; Draining lymph node cell; Chronic obstructive pulmonary disease; Retinoic acid receptor (RAR)-related orphan receptor; Aspergillus mitogilin; Concanavalin A; Natural killer; Pseudomonas aeruginosa early log-phase sonicate antigen; Pseudomonadales; 22; Lung; Interleukin 22; Transplantation; Pseudomonas; Respiratory system; Fungi; Aspergillus; Immunology; T; Surgery; T-Lymphocyte; Bacteria; Graft; Pseudomonadaceae; Fungi Imperfecti; Th17 lymphocyte; Species; Pancreatic disease; Human; Immunopathology; Immune response; Lymph node; Respiratory disease; Chronic disease; 17; Cytokine; Metabolic diseases; Cystic fibrosis; Interleukin 17; Genetic disease; Memory lymphocyte; Infection; Treatment; Digestive diseases

IL-17 is an important cytokine signature of the TH differentiation pathway TH17. This T-cell subset is crucial in mediating autoimmune disease or antimicrobial immunity in animal models, but its presence and role in human disease remain to be completely characterized. We set out to determine the fre...