Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes

IL-17 is an important cytokine signature of the TH differentiation pathway TH17. This T-cell subset is crucial in mediating autoimmune disease or antimicrobial immunity in animal models, but its presence and role in human disease remain to be completely characterized. We set out to determine the fre...

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Published inJournal of allergy and clinical immunology Vol. 131; no. 4; pp. 1117 - 1129.e5
Main Authors Chan, Yvonne R., Chen, Kong, Duncan, Steven R., Lathrop, Kira L., Latoche, Joseph D., Logar, Alison J., Pociask, Derek A., Wahlberg, Brendon J., Ray, Prabir, Ray, Anuradha, Pilewski, Joseph M., Kolls, Jay K.
Format Journal Article
LanguageEnglish
Published New York, NY Mosby, Inc 01.04.2013
Elsevier
Elsevier Limited
Subjects
Adult
Aged
Allergy and Immunology
animal models
Antigens
Antigens, Bacterial - immunology
Antigens, Bacterial - pharmacology
Antigens, Fungal - immunology
Antigens, Fungal - pharmacology
Aspergillus
Aspergillus - chemistry
Aspergillus species
autoimmune diseases
Biological and medical sciences
Case-Control Studies
Cell Proliferation - drug effects
chronic infectious disease
Chronic obstructive pulmonary disease
Cystic fibrosis
Cystic Fibrosis - genetics
Cystic Fibrosis - immunology
Cystic Fibrosis - pathology
Disease
Errors of metabolism
Female
flow cytometry
fluorescent antibody technique
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Fungal infections
Gene Expression
human diseases
Human subjects
Humans
IL-17
IL-22
Immune system
immunity
Immunologic Memory
Immunopathology
Immunophenotyping
interleukin-17
Interleukin-17 - genetics
Interleukin-17 - immunology
Interleukin-22
Interleukins - genetics
Interleukins - immunology
Lung - drug effects
Lung - immunology
Lung - pathology
lung transplant
Lungs
lymph nodes
Lymph Nodes - drug effects
Lymph Nodes - immunology
Lymph Nodes - pathology
Lymphocyte Activation - drug effects
Male
Medical sciences
memory T-cell response
Metabolic diseases
Middle Aged
Miscellaneous hereditary metabolic disorders
organ transplantation
pathogens
patients
phenotype
Pseudomonas aeruginosa
Pseudomonas aeruginosa - chemistry
Pseudomonas species
quantitative polymerase chain reaction
Review boards
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Studies
T-lymphocytes
TH17
Th17 Cells - drug effects
Th17 Cells - immunology
Th17 Cells - pathology
TH22
Transplants & implants
memory T-cell response
CORE
TCR
CF
Aspergillus species
lung transplant
Pa(EL)
PLC
Con A
DLN
IL-22
TH22
ROR
cystic fibrosis
IL-17
Pseudomonas species
chronic infectious disease
TH17
NK
Asp
COPD
Pa(LL)
Parenchymal lung leukocyte
Center for Organ Recovery and Education
Pseudomonas aeruginosa late log-phase filtrate antigen
T H17
T-cell receptor
T H22
Draining lymph node cell
Chronic obstructive pulmonary disease
Retinoic acid receptor (RAR)-related orphan receptor
Aspergillus mitogilin
Concanavalin A
Natural killer
Pseudomonas aeruginosa early log-phase sonicate antigen
Pseudomonadales
22
Lung
Interleukin 22
Transplantation
Pseudomonas
Respiratory system
Fungi
Aspergillus
Immunology
T
Surgery
T-Lymphocyte
Bacteria
Graft
Pseudomonadaceae
Fungi Imperfecti
Th17 lymphocyte
Species
Pancreatic disease
Human
Immunopathology
Immune response
Lymph node
Respiratory disease
Chronic disease
17
Cytokine
Metabolic diseases
Cystic fibrosis
Interleukin 17
Genetic disease
Memory lymphocyte
Infection
Treatment
Digestive diseases
Online AccessGet full text

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Abstract IL-17 is an important cytokine signature of the TH differentiation pathway TH17. This T-cell subset is crucial in mediating autoimmune disease or antimicrobial immunity in animal models, but its presence and role in human disease remain to be completely characterized. We set out to determine the frequency of TH17 cells in patients with cystic fibrosis (CF), a disease in which there is recurrent infection with known pathogens. Explanted lungs from patients undergoing transplantation or organ donors (CF samples = 18; non-CF, nonbronchiectatic samples = 10) were collected. Hilar nodes and parenchymal lung tissue were processed and examined for TH17 signature by using immunofluorescence and quantitative real-time PCR. T cells were isolated and stimulated with antigens from Pseudomonas aeruginosa and Aspergillus species. Cytokine profiles and staining with flow cytometry were used to assess the reactivity of these cells to antigen stimulation. We found a strong IL-17 phenotype in patients with CF compared with that seen in control subjects without CF. Within this tissue, we found pathogenic antigen–responsive CD4+IL-17+ cells. There were double-positive IL-17+IL-22+ cells [TH17(22)], and the IL-22+ population had a higher proportion of memory characteristics. Antigen-specific TH17 responses were stronger in the draining lymph nodes compared with those seen in matched parenchymal lungs. Inducible proliferation of TH17(22) with memory cell characteristics is seen in the lungs of patients with CF. The function of these individual subpopulations will require further study regarding their development. T cells are likely not the exclusive producers of IL-17 and IL-22, and this will require further characterization.
AbstractList IL-17 is an important cytokine signature of the TH differentiation pathway TH17. This T-cell subset is crucial in mediating autoimmune disease or antimicrobial immunity in animal models, but its presence and role in human disease remain to be completely characterized. We set out to determine the frequency of TH17 cells in patients with cystic fibrosis (CF), a disease in which there is recurrent infection with known pathogens. Explanted lungs from patients undergoing transplantation or organ donors (CF samples = 18; non-CF, nonbronchiectatic samples = 10) were collected. Hilar nodes and parenchymal lung tissue were processed and examined for TH17 signature by using immunofluorescence and quantitative real-time PCR. T cells were isolated and stimulated with antigens from Pseudomonas aeruginosa and Aspergillus species. Cytokine profiles and staining with flow cytometry were used to assess the reactivity of these cells to antigen stimulation. We found a strong IL-17 phenotype in patients with CF compared with that seen in control subjects without CF. Within this tissue, we found pathogenic antigen–responsive CD4+IL-17+ cells. There were double-positive IL-17+IL-22+ cells [TH17(22)], and the IL-22+ population had a higher proportion of memory characteristics. Antigen-specific TH17 responses were stronger in the draining lymph nodes compared with those seen in matched parenchymal lungs. Inducible proliferation of TH17(22) with memory cell characteristics is seen in the lungs of patients with CF. The function of these individual subpopulations will require further study regarding their development. T cells are likely not the exclusive producers of IL-17 and IL-22, and this will require further characterization.
Background IL-17 is an important cytokine signature of the TH differentiation pathway TH 17. This T-cell subset is crucial in mediating autoimmune disease or antimicrobial immunity in animal models, but its presence and role in human disease remain to be completely characterized. Objective We set out to determine the frequency of TH 17 cells in patients with cystic fibrosis (CF), a disease in which there is recurrent infection with known pathogens. Methods Explanted lungs from patients undergoing transplantation or organ donors (CF samples = 18; non-CF, nonbronchiectatic samples = 10) were collected. Hilar nodes and parenchymal lung tissue were processed and examined for TH 17 signature by using immunofluorescence and quantitative real-time PCR. T cells were isolated and stimulated with antigens from Pseudomonas aeruginosa and Aspergillus species. Cytokine profiles and staining with flow cytometry were used to assess the reactivity of these cells to antigen stimulation. Results We found a strong IL-17 phenotype in patients with CF compared with that seen in control subjects without CF. Within this tissue, we found pathogenic antigen–responsive CD4+ IL-17+ cells. There were double-positive IL-17+ IL-22+ cells [TH 17(22)], and the IL-22+ population had a higher proportion of memory characteristics. Antigen-specific TH 17 responses were stronger in the draining lymph nodes compared with those seen in matched parenchymal lungs. Conclusion Inducible proliferation of TH 17(22) with memory cell characteristics is seen in the lungs of patients with CF. The function of these individual subpopulations will require further study regarding their development. T cells are likely not the exclusive producers of IL-17 and IL-22, and this will require further characterization.
BACKGROUND: IL-17 is an important cytokine signature of the TH differentiation pathway TH17. This T-cell subset is crucial in mediating autoimmune disease or antimicrobial immunity in animal models, but its presence and role in human disease remain to be completely characterized. OBJECTIVE: We set out to determine the frequency of TH17 cells in patients with cystic fibrosis (CF), a disease in which there is recurrent infection with known pathogens. METHODS: Explanted lungs from patients undergoing transplantation or organ donors (CF samples = 18; non-CF, nonbronchiectatic samples = 10) were collected. Hilar nodes and parenchymal lung tissue were processed and examined for TH17 signature by using immunofluorescence and quantitative real-time PCR. T cells were isolated and stimulated with antigens from Pseudomonas aeruginosa and Aspergillus species. Cytokine profiles and staining with flow cytometry were used to assess the reactivity of these cells to antigen stimulation. RESULTS: We found a strong IL-17 phenotype in patients with CF compared with that seen in control subjects without CF. Within this tissue, we found pathogenic antigen–responsive CD4⁺IL-17⁺ cells. There were double-positive IL-17⁺IL-22⁺ cells [TH17(22)], and the IL-22⁺ population had a higher proportion of memory characteristics. Antigen-specific TH17 responses were stronger in the draining lymph nodes compared with those seen in matched parenchymal lungs. CONCLUSION: Inducible proliferation of TH17(22) with memory cell characteristics is seen in the lungs of patients with CF. The function of these individual subpopulations will require further study regarding their development. T cells are likely not the exclusive producers of IL-17 and IL-22, and this will require further characterization.
IL-17 is an important cytokine signature of the TH differentiation pathway TH17. This T-cell subset is crucial in mediating autoimmune disease or antimicrobial immunity in animal models, but its presence and role in human disease remain to be completely characterized. We set out to determine the frequency of TH17 cells in patients with cystic fibrosis (CF), a disease in which there is recurrent infection with known pathogens. Explanted lungs from patients undergoing transplantation or organ donors (CF samples=18; non-CF, nonbronchiectatic samples=10) were collected. Hilar nodes and parenchymal lung tissue were processed and examined for TH17 signature by using immunofluorescence and quantitative real-time PCR. T cells were isolated and stimulated with antigens from Pseudomonas aeruginosa and Aspergillus species. Cytokine profiles and staining with flow cytometry were used to assess the reactivity of these cells to antigen stimulation. We found a strong IL-17 phenotype in patients with CF compared with that seen in control subjects without CF. Within this tissue, we found pathogenic antigen-responsive CD4+IL-17+ cells. There were double-positive IL-17+IL-22+ cells [TH17(22)], and the IL-22+ population had a higher proportion of memory characteristics. Antigen-specific TH17 responses were stronger in the draining lymph nodes compared with those seen in matched parenchymal lungs. Inducible proliferation of TH17(22) with memory cell characteristics is seen in the lungs of patients with CF. The function of these individual subpopulations will require further study regarding their development. T cells are likely not the exclusive producers of IL-17 and IL-22, and this will require further characterization.
Background IL-17 is an important cytokine signature of the THdifferentiation pathway TH17. This T-cell subset is crucial in mediating autoimmune disease or antimicrobial immunity in animal models, but its presence and role in human disease remain to be completely characterized. Objective We set out to determine the frequency of TH17 cells in patients with cystic fibrosis (CF), a disease in which there is recurrent infection with known pathogens. Methods Explanted lungs from patients undergoing transplantation or organ donors (CF samples = 18; non-CF, nonbronchiectatic samples = 10) were collected. Hilar nodes and parenchymal lung tissue were processed and examined for TH17 signature by using immunofluorescence and quantitative real-time PCR. T cells were isolated and stimulated with antigens fromPseudomonas aeruginosaandAspergillusspecies. Cytokine profiles and staining with flow cytometry were used to assess the reactivity of these cells to antigen stimulation. Results We found a strong IL-17 phenotype in patients with CF compared with that seen in control subjects without CF. Within this tissue, we found pathogenic antigen-responsive CD4+IL-17+cells. There were double-positive IL-17+IL-22+cells [TH17(22)], and the IL-22+population had a higher proportion of memory characteristics. Antigen-specific TH17 responses were stronger in the draining lymph nodes compared with those seen in matched parenchymal lungs. Conclusion Inducible proliferation of TH17(22) with memory cell characteristics is seen in the lungs of patients with CF. The function of these individual subpopulations will require further study regarding their development. T cells are likely not the exclusive producers of IL-17 and IL-22, and this will require further characterization.
IL-17 is an important cytokine signature of the TH differentiation pathway TH17. This T-cell subset is crucial in mediating autoimmune disease or antimicrobial immunity in animal models, but its presence and role in human disease remain to be completely characterized.BACKGROUNDIL-17 is an important cytokine signature of the TH differentiation pathway TH17. This T-cell subset is crucial in mediating autoimmune disease or antimicrobial immunity in animal models, but its presence and role in human disease remain to be completely characterized.We set out to determine the frequency of TH17 cells in patients with cystic fibrosis (CF), a disease in which there is recurrent infection with known pathogens.OBJECTIVEWe set out to determine the frequency of TH17 cells in patients with cystic fibrosis (CF), a disease in which there is recurrent infection with known pathogens.Explanted lungs from patients undergoing transplantation or organ donors (CF samples=18; non-CF, nonbronchiectatic samples=10) were collected. Hilar nodes and parenchymal lung tissue were processed and examined for TH17 signature by using immunofluorescence and quantitative real-time PCR. T cells were isolated and stimulated with antigens from Pseudomonas aeruginosa and Aspergillus species. Cytokine profiles and staining with flow cytometry were used to assess the reactivity of these cells to antigen stimulation.METHODSExplanted lungs from patients undergoing transplantation or organ donors (CF samples=18; non-CF, nonbronchiectatic samples=10) were collected. Hilar nodes and parenchymal lung tissue were processed and examined for TH17 signature by using immunofluorescence and quantitative real-time PCR. T cells were isolated and stimulated with antigens from Pseudomonas aeruginosa and Aspergillus species. Cytokine profiles and staining with flow cytometry were used to assess the reactivity of these cells to antigen stimulation.We found a strong IL-17 phenotype in patients with CF compared with that seen in control subjects without CF. Within this tissue, we found pathogenic antigen-responsive CD4+IL-17+ cells. There were double-positive IL-17+IL-22+ cells [TH17(22)], and the IL-22+ population had a higher proportion of memory characteristics. Antigen-specific TH17 responses were stronger in the draining lymph nodes compared with those seen in matched parenchymal lungs.RESULTSWe found a strong IL-17 phenotype in patients with CF compared with that seen in control subjects without CF. Within this tissue, we found pathogenic antigen-responsive CD4+IL-17+ cells. There were double-positive IL-17+IL-22+ cells [TH17(22)], and the IL-22+ population had a higher proportion of memory characteristics. Antigen-specific TH17 responses were stronger in the draining lymph nodes compared with those seen in matched parenchymal lungs.Inducible proliferation of TH17(22) with memory cell characteristics is seen in the lungs of patients with CF. The function of these individual subpopulations will require further study regarding their development. T cells are likely not the exclusive producers of IL-17 and IL-22, and this will require further characterization.CONCLUSIONInducible proliferation of TH17(22) with memory cell characteristics is seen in the lungs of patients with CF. The function of these individual subpopulations will require further study regarding their development. T cells are likely not the exclusive producers of IL-17 and IL-22, and this will require further characterization.
Author Pilewski, Joseph M.
Duncan, Steven R.
Latoche, Joseph D.
Logar, Alison J.
Pociask, Derek A.
Ray, Anuradha
Chen, Kong
Lathrop, Kira L.
Wahlberg, Brendon J.
Ray, Prabir
Kolls, Jay K.
Chan, Yvonne R.
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  fullname: Chen, Kong
  organization: Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh, Pittsburgh, Pa
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  surname: Duncan
  fullname: Duncan, Steven R.
  organization: Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pa
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  surname: Lathrop
  fullname: Lathrop, Kira L.
  organization: Eye and Ear Institute, University of Pittsburgh, Pittsburgh, Pa
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  givenname: Joseph D.
  surname: Latoche
  fullname: Latoche, Joseph D.
  organization: Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pa
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  fullname: Logar, Alison J.
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  organization: Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh, Pittsburgh, Pa
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  givenname: Brendon J.
  surname: Wahlberg
  fullname: Wahlberg, Brendon J.
  organization: Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pa
– sequence: 9
  givenname: Prabir
  surname: Ray
  fullname: Ray, Prabir
  organization: Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pa
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  givenname: Anuradha
  surname: Ray
  fullname: Ray, Anuradha
  organization: Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pa
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  givenname: Jay K.
  surname: Kolls
  fullname: Kolls, Jay K.
  organization: Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh, Pittsburgh, Pa
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Cites_doi 10.1038/mt.2009.149
10.1016/1074-7613(95)90070-5
10.1016/j.immuni.2008.11.009
10.1038/ni1261
10.1038/nri2433
10.1172/JCI42388
10.1084/jem.20061308
10.1084/jem.20050193
10.1038/ni1254
10.4049/jimmunol.136.7.2348
10.1126/scitranslmed.3000928
10.1084/jem.183.6.2593
10.1038/nm1710
10.1016/j.immuni.2007.11.016
10.1152/ajplung.00344.2007
10.1053/rmed.2003.1507
10.1111/j.1365-2249.2009.03965.x
10.1038/bmt.2010.28
10.1165/rcmb.2003-0285OC
10.4049/jimmunol.0803868
10.4049/jimmunol.181.12.8504
10.1097/TP.0b013e3181fdd948
10.1111/j.1365-2567.2009.03240.x
10.1378/chest.117.5_suppl_1.286S
10.1136/thorax.57.9.759
10.4049/jimmunol.0803803
10.1164/rccm.200210-1179OC
10.1073/pnas.2634339100
10.1080/15412550701817656
10.1002/eji.200737409
10.4049/jimmunol.175.1.404
10.4049/jimmunol.0903961
10.1164/rccm.200401-094OC
10.1016/j.jaci.2010.11.043
10.1016/j.immuni.2006.01.001
10.1074/jbc.M109.017129
10.1084/jem.20091983
10.4049/jimmunol.0902999
10.1111/j.1399-0012.2010.01362.x
10.1038/nature04753
10.1096/fj.05-4406com
10.1183/09031936.03.00303503
10.1165/ajrcmb.25.3.4424
10.1038/nature07537
10.1182/blood-2005-09-010116
10.1165/ajrcmb.26.1.4253
10.1007/s10875-005-5625-6
10.1111/j.1440-1711.2005.01365.x
10.4049/jimmunol.173.5.3482
10.1136/thx.2005.051979
10.4049/jimmunol.155.12.5483
10.1067/mai.2003.1557
10.1038/nature06471
10.1164/rccm.200506-859OC
10.1016/j.ymthe.2005.08.025
10.1084/jem.20081463
10.1128/IAI.66.3.959-965.1998
10.1152/ajplung.00312.2006
10.1097/TP.0b013e3181bcde7b
10.1189/jlb.0904490
10.4049/jimmunol.0803282
10.1084/jem.194.4.519
10.1038/nature04754
10.1128/IAI.65.12.5052-5056.1997
10.4049/jimmunol.162.4.2347
10.4049/jimmunol.150.12.5445
10.1038/nri1418
10.1038/nm1743
10.1126/scitranlsmed.3000154
ContentType Journal Article
Copyright 2012 American Academy of Allergy, Asthma & Immunology
American Academy of Allergy, Asthma & Immunology
2014 INIST-CNRS
Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Copyright Elsevier Limited Apr 2013
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– notice: American Academy of Allergy, Asthma & Immunology
– notice: 2014 INIST-CNRS
– notice: Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
– notice: Copyright Elsevier Limited Apr 2013
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Issue 4
Keywords memory T-cell response
CORE
TCR
CF
Aspergillus species
lung transplant
Pa(EL)
PLC
Con A
DLN
IL-22
TH22
ROR
cystic fibrosis
IL-17
Pseudomonas species
chronic infectious disease
TH17
NK
Asp
COPD
Pa(LL)
Parenchymal lung leukocyte
Center for Organ Recovery and Education
Pseudomonas aeruginosa late log-phase filtrate antigen
T H17
T-cell receptor
T H22
Draining lymph node cell
Chronic obstructive pulmonary disease
Retinoic acid receptor (RAR)-related orphan receptor
Aspergillus mitogilin
Concanavalin A
Natural killer
Pseudomonas aeruginosa early log-phase sonicate antigen
Pseudomonadales
22
Lung
Interleukin 22
Transplantation
Pseudomonas
Respiratory system
Fungi
Aspergillus
Immunology
T
Surgery
T-Lymphocyte
Bacteria
Graft
Pseudomonadaceae
Fungi Imperfecti
Th17 lymphocyte
Species
Pancreatic disease
Human
Immunopathology
Immune response
Lymph node
Respiratory disease
Chronic disease
17
Cytokine
Metabolic diseases
Cystic fibrosis
Interleukin 17
Genetic disease
Memory lymphocyte
Infection
Treatment
Digestive diseases
Language English
License https://www.elsevier.com/tdm/userlicense/1.0
CC BY 4.0
Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
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PublicationTitle Journal of allergy and clinical immunology
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References Patel, Seemungal, Wilks, Lloyd-Owen, Donaldson, Wedzicha (bib38) 2002; 57
Gibbons, Israel, Deykin, Schaub, He, Perkins (bib66) 2005; 25
Lefrançois, Lycke (bib46) 2001
Mosmann, Cherwinski, Bond, Giedlin, Coffman (bib1) 1986; 136
Kreindler, Bertrand, Lee, Karasic, Aujla, Pilewski (bib32) 2009; 296
Chakir, Shannon, Molet, Fukakusa, Elias, Laviolette (bib23) 2003; 111
Sethi (bib26) 2000; 117
Harrington, Hatton, Mangan, Turner, Murphy, Murphy (bib18) 2005; 6
Yao, Fanslow, Seldin, Rousseau, Painter, Comeau (bib3) 1995; 3
Rowe, Lopes, Ikeda, Bailey, Barde, Zenke (bib53) 2006; 13
Yu, Ruddy, Wong, Sfintescu, Baker, Smith (bib27) 2007; 109
Chan, Liu, Pociask, Zheng, Mietzner, Berger (bib28) 2009; 182
Romani, Fallarino, De Luca, Montagnoli, D'Angelo, Zelante (bib55) 2008; 451
Laan, Prause, Miyamoto, Sjostrand, Hytonen, Kaneko (bib8) 2003; 21
Newcomb, Boswell, Zhou, Huckabee, Goleniewska, Sevin (bib50) 2011; 127
Ishigame, Kakuta, Nagai, Kadoki, Nambu, Komiyama (bib14) 2009; 30
Aujla, Chan, Zheng, Fei, Askew, Pociask (bib44) 2008; 14
Newcomb, Zhou, Moore, Goleniewska, Hershey, Kolls (bib49) 2009; 182
Braun, Molitor-Dart, Wigfield, Xiang, Fain, Jankowska-Gan (bib67) 2009; 88
Wang, Li, Xie, Wang, Xia, Ye (bib70) 2011; 25
Laan, Cui, Hoshino, Lotvall, Sjostrand, Gruenert (bib7) 1999; 162
Morris, Sciurba, Lebedeva, Githaiga, Elliott, Hogg (bib40) 2004; 170
Fossiez, Djossou, Chomarat, Flores-Romo, Ait-Yahia, Maat (bib6) 1996; 183
Kruisbeek (bib45) 2001
Eyerich, Eyerich, Pennino, Carbone, Nasorri, Pallotta (bib62) 2009; 119
Onishi, Gaffen (bib16) 2010; 129
Di Stefano, Caramori, Gnemmi, Contoli, Vicari, Capelli (bib25) 2009; 157
Papi, Bellettato, Braccioni, Romagnoli, Casolari, Caramori (bib37) 2006; 173
Lebre, Burwell, Vieira, Lora, Coyle, Kapsenberg (bib65) 2005; 83
Carvalho, Cunha, Di Ianni, Pitzurra, Aloisi, Falzetti (bib72) 2010; 45
Shen, Ruddy, Plamondon, Gaffen (bib35) 2005; 77
McAllister, Henry, Kreindler, Dubin, Ulrich, Steele (bib24) 2005; 175
Yao, Painter, Fanslow, Ulrich, Macduff, Spriggs (bib4) 1995; 155
Barczyk, Pierzchala, Sozanska (bib22) 2003; 97
Kolls, McCray, Chan (bib31) 2008; 8
Stoltz, Meyerholz, Pezzulo, Ramachandran, Rogan, Davis (bib54) 2010; 2
Coakley, Grubb, Paradiso, Gatzy, Johnson, Kreda (bib56) 2003; 100
Deteix, Attuil-Audenis, Duthey, Patey, McGregor, Dubois (bib68) 2010; 184
Dubin, Kolls (bib59) 2007; 292
Conti, Shen, Nayyar, Stocum, Sun, Lindemann (bib15) 2009; 206
Yang, Pappu, Nurieva, Akimzhanov, Kang, Chung (bib48) 2008; 28
Kao, Chen, Thai, Wachi, Huang, Kim (bib29) 2004; 173
Dorschner, Lopez-Garcia, Peschel, Kraus, Morikawa, Nizet (bib57) 2006; 20
Rouvier, Luciani, Mattei, Denizot, Golstein (bib5) 1993; 150
Peric, Koglin, Kim, Morizane, Besch, Prinz (bib34) 2008; 181
Karlsen, Borregaard, Cowland (bib30) 2010; 285
Xie, Wang, Zhang, Wang, Ye, Li (bib71) 2011; 91
Wilkinson, Patel, Wilks, Donaldson, Wedzicha (bib39) 2003; 167
Arce, Rowe, Chain, Lopes, Collins (bib52) 2009; 17
Ye, Rodriguez, Kanaly, Stocking, Schurr, Schwarzenberger (bib9) 2001; 194
Happel, Dubin, Zheng, Ghilardi, Lockhart, Quinton (bib11) 2005; 202
Puel, Doffinger, Natividad, Chrabieh, Barcenas-Morales, Picard (bib21) 2010; 207
Meshi, Vitalis, Ionescu, Elliott, Liu, Wang (bib36) 2002; 26
Morris, Sciurba, Norris (bib41) 2008; 5
Garvy, Wiley, Gigliotti, Harmsen (bib2) 1997; 65
Mangan, Harrington, O'Quinn, Helms, Bullard, Elson (bib13) 2006; 441
Cella, Fuchs, Vermi, Facchetti, Otero, Lennerz (bib60) 2009; 457
Liang, Tan, Luxenberg, Karim, Dunussi-Joannopoulos, Collins (bib33) 2006; 203
Vokaer, Van Rompaey, Lemaitre, Lhomme, Kubjak, Benghiat (bib69) 2010; 185
Elkington, Friedland (bib42) 2006; 61
Raffatellu, Santos, Verhoeven, George, Wilson, Winter (bib12) 2008; 14
Bettelli, Carrier, Gao, Korn, Strom, Oukka (bib17) 2006; 441
Shan, Cheng, Song, Roberts, Green, Hacken-Bitar (bib63) 2009; 1
Veldhoen, Hocking, Atkins, Locksley, Stockinger (bib20) 2006; 24
Parks, Wilson, Lopez-Boado (bib43) 2004; 4
Ye, Garvey, Zhang, Nelson, Bagby, Summer (bib10) 2001; 25
Park, Li, Yang, Chang, Nurieva, Wang (bib19) 2005; 6
Naess, Oftung, Aase, Wetzler, Sandin, Michaelsen (bib51) 1998; 66
Whittington, Armstrong, Uppington, Millar (bib61) 2004; 31
Zelante, De Luca, Bonifazi, Montagnoli, Bozza, Moretti (bib58) 2007; 37
Walsh, Brady, Finlay, Boon, Mills (bib64) 2009; 183
Kreindler, Steele, Nguyen, Chan, Pilewski, Alcorn (bib47) 2010; 120
Harrington (10.1016/j.jaci.2012.05.036_bib18) 2005; 6
Parks (10.1016/j.jaci.2012.05.036_bib43) 2004; 4
Garvy (10.1016/j.jaci.2012.05.036_bib2) 1997; 65
Mosmann (10.1016/j.jaci.2012.05.036_bib1) 1986; 136
Braun (10.1016/j.jaci.2012.05.036_bib67) 2009; 88
Elkington (10.1016/j.jaci.2012.05.036_bib42) 2006; 61
Rouvier (10.1016/j.jaci.2012.05.036_bib5) 1993; 150
Eyerich (10.1016/j.jaci.2012.05.036_bib62) 2009; 119
Patel (10.1016/j.jaci.2012.05.036_bib38) 2002; 57
Peric (10.1016/j.jaci.2012.05.036_bib34) 2008; 181
Meshi (10.1016/j.jaci.2012.05.036_bib36) 2002; 26
Kruisbeek (10.1016/j.jaci.2012.05.036_bib45) 2001
Barczyk (10.1016/j.jaci.2012.05.036_bib22) 2003; 97
Wang (10.1016/j.jaci.2012.05.036_bib70) 2011; 25
Laan (10.1016/j.jaci.2012.05.036_bib7) 1999; 162
Kreindler (10.1016/j.jaci.2012.05.036_bib32) 2009; 296
Ye (10.1016/j.jaci.2012.05.036_bib10) 2001; 25
Karlsen (10.1016/j.jaci.2012.05.036_bib30) 2010; 285
Cella (10.1016/j.jaci.2012.05.036_bib60) 2009; 457
Yu (10.1016/j.jaci.2012.05.036_bib27) 2007; 109
Xie (10.1016/j.jaci.2012.05.036_bib71) 2011; 91
Morris (10.1016/j.jaci.2012.05.036_bib40) 2004; 170
Kao (10.1016/j.jaci.2012.05.036_bib29) 2004; 173
Liang (10.1016/j.jaci.2012.05.036_bib33) 2006; 203
Raffatellu (10.1016/j.jaci.2012.05.036_bib12) 2008; 14
Newcomb (10.1016/j.jaci.2012.05.036_bib49) 2009; 182
Ishigame (10.1016/j.jaci.2012.05.036_bib14) 2009; 30
Lebre (10.1016/j.jaci.2012.05.036_bib65) 2005; 83
Deteix (10.1016/j.jaci.2012.05.036_bib68) 2010; 184
Mangan (10.1016/j.jaci.2012.05.036_bib13) 2006; 441
Rowe (10.1016/j.jaci.2012.05.036_bib53) 2006; 13
Yao (10.1016/j.jaci.2012.05.036_bib3) 1995; 3
Laan (10.1016/j.jaci.2012.05.036_bib8) 2003; 21
Shen (10.1016/j.jaci.2012.05.036_bib35) 2005; 77
Shan (10.1016/j.jaci.2012.05.036_bib63) 2009; 1
Romani (10.1016/j.jaci.2012.05.036_bib55) 2008; 451
Whittington (10.1016/j.jaci.2012.05.036_bib61) 2004; 31
Puel (10.1016/j.jaci.2012.05.036_bib21) 2010; 207
Kreindler (10.1016/j.jaci.2012.05.036_bib47) 2010; 120
Chan (10.1016/j.jaci.2012.05.036_bib28) 2009; 182
Di Stefano (10.1016/j.jaci.2012.05.036_bib25) 2009; 157
Zelante (10.1016/j.jaci.2012.05.036_bib58) 2007; 37
Aujla (10.1016/j.jaci.2012.05.036_bib44) 2008; 14
Walsh (10.1016/j.jaci.2012.05.036_bib64) 2009; 183
Stoltz (10.1016/j.jaci.2012.05.036_bib54) 2010; 2
Happel (10.1016/j.jaci.2012.05.036_bib11) 2005; 202
Bettelli (10.1016/j.jaci.2012.05.036_bib17) 2006; 441
Conti (10.1016/j.jaci.2012.05.036_bib15) 2009; 206
McAllister (10.1016/j.jaci.2012.05.036_bib24) 2005; 175
Naess (10.1016/j.jaci.2012.05.036_bib51) 1998; 66
Dubin (10.1016/j.jaci.2012.05.036_bib59) 2007; 292
Yang (10.1016/j.jaci.2012.05.036_bib48) 2008; 28
Kolls (10.1016/j.jaci.2012.05.036_bib31) 2008; 8
Morris (10.1016/j.jaci.2012.05.036_bib41) 2008; 5
Wilkinson (10.1016/j.jaci.2012.05.036_bib39) 2003; 167
Onishi (10.1016/j.jaci.2012.05.036_bib16) 2010; 129
Sethi (10.1016/j.jaci.2012.05.036_bib26) 2000; 117
Dorschner (10.1016/j.jaci.2012.05.036_bib57) 2006; 20
Fossiez (10.1016/j.jaci.2012.05.036_bib6) 1996; 183
Veldhoen (10.1016/j.jaci.2012.05.036_bib20) 2006; 24
Newcomb (10.1016/j.jaci.2012.05.036_bib50) 2011; 127
Park (10.1016/j.jaci.2012.05.036_bib19) 2005; 6
Papi (10.1016/j.jaci.2012.05.036_bib37) 2006; 173
Yao (10.1016/j.jaci.2012.05.036_bib4) 1995; 155
Arce (10.1016/j.jaci.2012.05.036_bib52) 2009; 17
Coakley (10.1016/j.jaci.2012.05.036_bib56) 2003; 100
Carvalho (10.1016/j.jaci.2012.05.036_bib72) 2010; 45
Lefrançois (10.1016/j.jaci.2012.05.036_bib46) 2001
Gibbons (10.1016/j.jaci.2012.05.036_bib66) 2005; 25
Ye (10.1016/j.jaci.2012.05.036_bib9) 2001; 194
Chakir (10.1016/j.jaci.2012.05.036_bib23) 2003; 111
Vokaer (10.1016/j.jaci.2012.05.036_bib69) 2010; 185
References_xml – volume: 202
  start-page: 761
  year: 2005
  end-page: 769
  ident: bib11
  article-title: Divergent roles of IL-23 and IL-12 in host defense against
  publication-title: J Exp Med
– volume: 441
  start-page: 231
  year: 2006
  end-page: 234
  ident: bib13
  article-title: Transforming growth factor-beta induces development of the T(H)17 lineage
  publication-title: Nature
– volume: 6
  start-page: 1133
  year: 2005
  end-page: 1141
  ident: bib19
  article-title: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
  publication-title: Nat Immunol
– volume: 65
  start-page: 5052
  year: 1997
  end-page: 5056
  ident: bib2
  article-title: Protection against
  publication-title: Infect Immun
– volume: 117
  start-page: 286S
  year: 2000
  end-page: 291S
  ident: bib26
  article-title: Bacterial infection and the pathogenesis of COPD
  publication-title: Chest
– volume: 181
  start-page: 8504
  year: 2008
  end-page: 8512
  ident: bib34
  article-title: IL-17A enhances vitamin D3-induced expression of cathelicidin antimicrobial peptide in human keratinocytes
  publication-title: J Immunol
– volume: 173
  start-page: 1114
  year: 2006
  end-page: 1121
  ident: bib37
  article-title: Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations
  publication-title: Am J Respir Crit Care Med
– volume: 100
  start-page: 16083
  year: 2003
  end-page: 16088
  ident: bib56
  article-title: Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium
  publication-title: Proc Natl Acad Sci U S A
– volume: 1
  start-page: 4ra10
  year: 2009
  ident: bib63
  article-title: Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema
  publication-title: Sci Transl Med
– volume: 129
  start-page: 311
  year: 2010
  end-page: 321
  ident: bib16
  article-title: Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease
  publication-title: Immunology
– volume: 183
  start-page: 1577
  year: 2009
  end-page: 1586
  ident: bib64
  article-title: Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses
  publication-title: J Immunol
– volume: 57
  start-page: 759
  year: 2002
  end-page: 764
  ident: bib38
  article-title: Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations
  publication-title: Thorax
– volume: 91
  start-page: 27
  year: 2011
  end-page: 34
  ident: bib71
  article-title: Treatment With interleukin-12/23p40 antibody attenuates acute cardiac allograft rejection
  publication-title: Transplantation
– volume: 194
  start-page: 519
  year: 2001
  end-page: 527
  ident: bib9
  article-title: Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
  publication-title: J Exp Med
– volume: 26
  start-page: 52
  year: 2002
  end-page: 57
  ident: bib36
  article-title: Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response
  publication-title: Am J Respir Cell Mol Biol
– volume: 25
  start-page: 335
  year: 2001
  end-page: 340
  ident: bib10
  article-title: Interleukin-17 and lung host defense against
  publication-title: Am J Respir Cell Mol Biol
– volume: 184
  start-page: 5344
  year: 2010
  end-page: 5351
  ident: bib68
  article-title: Intragraft Th17 infiltrate promotes lymphoid neogenesis and hastens clinical chronic rejection
  publication-title: J Immunol
– volume: 155
  start-page: 5483
  year: 1995
  end-page: 5486
  ident: bib4
  article-title: Human IL-17: a novel cytokine derived from T cells
  publication-title: J Immunol
– volume: 25
  start-page: 437
  year: 2005
  end-page: 444
  ident: bib66
  article-title: The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretion
  publication-title: J Clin Immunol
– volume: 25
  start-page: E177
  year: 2011
  end-page: E186
  ident: bib70
  article-title: Dynamic changes in Th1, Th17, and FoxP3(+) T cells in patients with acute cellular rejection after cardiac transplantation
  publication-title: Clin Transplant
– volume: 45
  start-page: 1645
  year: 2010
  end-page: 1652
  ident: bib72
  article-title: Prognostic significance of genetic variants in the IL-23/Th17 pathway for the outcome of T cell-depleted allogeneic stem cell transplantation
  publication-title: Bone Marrow Transplant
– volume: 88
  start-page: 1341
  year: 2009
  end-page: 1348
  ident: bib67
  article-title: Transfer of tolerance to collagen type V suppresses T-helper-cell-17 lymphocyte-mediated acute lung transplant rejection
  publication-title: Transplantation
– volume: 173
  start-page: 3482
  year: 2004
  end-page: 3491
  ident: bib29
  article-title: IL-17 Markedly up-regulates β-defensin-2 expression in human airway epithelium via JAK and NF-κB signaling pathways
  publication-title: J Immunol
– volume: 441
  start-page: 235
  year: 2006
  end-page: 238
  ident: bib17
  article-title: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
  publication-title: Nature
– volume: 3
  start-page: 811
  year: 1995
  end-page: 821
  ident: bib3
  article-title: Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor
  publication-title: Immunity
– volume: 14
  start-page: 421
  year: 2008
  end-page: 428
  ident: bib12
  article-title: Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes
  publication-title: Nat Med
– volume: 14
  start-page: 275
  year: 2008
  end-page: 281
  ident: bib44
  article-title: IL-22 mediates mucosal host defense against gram-negative bacterial pneumonia
  publication-title: Nat Med
– volume: 183
  start-page: 2593
  year: 1996
  end-page: 2603
  ident: bib6
  article-title: T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
  publication-title: J Exp Med
– volume: 150
  start-page: 5445
  year: 1993
  end-page: 5456
  ident: bib5
  article-title: CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus Saimiri gene
  publication-title: J Immunol
– volume: 109
  start-page: 3794
  year: 2007
  end-page: 3802
  ident: bib27
  article-title: An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals
  publication-title: Blood
– volume: 77
  start-page: 388
  year: 2005
  end-page: 399
  ident: bib35
  article-title: Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-α-induced genes in bone cells
  publication-title: J Leukoc Biol
– volume: 451
  start-page: 211
  year: 2008
  end-page: 215
  ident: bib55
  article-title: Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
  publication-title: Nature
– volume: 111
  start-page: 1293
  year: 2003
  end-page: 1298
  ident: bib23
  article-title: Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression
  publication-title: J Allergy Clin Immunol
– volume: 21
  start-page: 387
  year: 2003
  end-page: 393
  ident: bib8
  article-title: A role of GM-CSF in the accumulation of neutrophils in the airways caused by IL-17 and TNF-alpha
  publication-title: Eur Respir J
– volume: 157
  start-page: 316
  year: 2009
  end-page: 324
  ident: bib25
  article-title: T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients
  publication-title: Clin Exp Immunol
– volume: 6
  start-page: 1123
  year: 2005
  end-page: 1132
  ident: bib18
  article-title: Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
  publication-title: Nat Immunol
– volume: 120
  start-page: 3242
  year: 2010
  end-page: 3254
  ident: bib47
  article-title: Vitamin D3 attenuates Th2 responses to
  publication-title: J Clin Invest
– volume: 285
  start-page: 14088
  year: 2010
  end-page: 14100
  ident: bib30
  article-title: Induction of neutrophil gelatinase-associated lipocalin expression by co-stimulation with interleukin-17 and tumor necrosis factor-alpha is controlled by IkappaB-zeta but neither by C/EBP-beta nor C/EBP-delta
  publication-title: J Biol Chem
– volume: 207
  start-page: 291
  year: 2010
  end-page: 297
  ident: bib21
  article-title: Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I
  publication-title: J Exp Med
– volume: 175
  start-page: 404
  year: 2005
  end-page: 412
  ident: bib24
  article-title: Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-α and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis
  publication-title: J Immunol
– volume: 162
  start-page: 2347
  year: 1999
  end-page: 2352
  ident: bib7
  article-title: Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways
  publication-title: J Immunol
– volume: 206
  start-page: 299
  year: 2009
  end-page: 311
  ident: bib15
  article-title: Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
  publication-title: J Exp Med
– volume: 8
  start-page: 829
  year: 2008
  end-page: 835
  ident: bib31
  article-title: Cytokine-mediated regulation of antimicrobial proteins
  publication-title: Nat Rev Immunol
– volume: 5
  start-page: 43
  year: 2008
  end-page: 51
  ident: bib41
  article-title: : a novel pathogen in chronic obstructive pulmonary disease?
  publication-title: COPD
– volume: 4
  start-page: 617
  year: 2004
  end-page: 629
  ident: bib43
  article-title: Matrix metalloproteinases as modulators of inflammation and innate immunity
  publication-title: Nat Rev Immunol
– volume: 167
  start-page: 1090
  year: 2003
  end-page: 1095
  ident: bib39
  article-title: Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary disease
  publication-title: Am J Respir Crit Care Med
– year: 2001
  ident: bib46
  article-title: Isolation of mouse small intestinal intraepithelial lymphocytes, peyer's patch, and lamina propria cells
  publication-title: Current protocols in immunology
– volume: 83
  start-page: 525
  year: 2005
  end-page: 535
  ident: bib65
  article-title: Differential expression of inflammatory chemokines by Th1- and Th2-cell promoting dendritic cells: a role for different mature dendritic cell populations in attracting appropriate effector cells to peripheral sites of inflammation
  publication-title: Immunol Cell Biol
– year: 2001
  ident: bib45
  article-title: Isolation of mouse mononuclear cells
  publication-title: Current protocols in immunology
– volume: 185
  start-page: 3417
  year: 2010
  end-page: 3425
  ident: bib69
  article-title: Critical role of regulatory T cells in Th17-mediated minor antigen-disparate rejection
  publication-title: J Immunol
– volume: 97
  start-page: 726
  year: 2003
  end-page: 733
  ident: bib22
  article-title: Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine
  publication-title: Respir Med
– volume: 292
  start-page: L519
  year: 2007
  end-page: L528
  ident: bib59
  article-title: IL-23 mediates inflammatory responses to mucoid
  publication-title: Am J Physiol Lung Cell Mol Physiol
– volume: 28
  start-page: 29
  year: 2008
  end-page: 39
  ident: bib48
  article-title: T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
  publication-title: Immunity
– volume: 296
  start-page: L257
  year: 2009
  end-page: L266
  ident: bib32
  article-title: Interleukin-17A induces bicarbonate secretion in normal human bronchial epithelial cells
  publication-title: Am J Physiol Lung Cell Mol Physiol
– volume: 13
  start-page: 310
  year: 2006
  end-page: 319
  ident: bib53
  article-title: Immunization with a lentiviral vector stimulates both CD4 and CD8 T cell responses to an ovalbumin transgene
  publication-title: Mol Ther
– volume: 20
  start-page: 35
  year: 2006
  end-page: 42
  ident: bib57
  article-title: The mammalian ionic environment dictates microbial susceptibility to antimicrobial defense peptides
  publication-title: FASEB J
– volume: 136
  start-page: 2348
  year: 1986
  end-page: 2357
  ident: bib1
  article-title: Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
  publication-title: J Immunol
– volume: 127
  start-page: 1006
  year: 2011
  end-page: 1013
  ident: bib50
  article-title: Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production
  publication-title: Journal Allergy Clin Immunol
– volume: 37
  start-page: 2695
  year: 2007
  end-page: 2706
  ident: bib58
  article-title: IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance
  publication-title: Eur J Immunol
– volume: 61
  start-page: 259
  year: 2006
  end-page: 266
  ident: bib42
  article-title: Matrix metalloproteinases in destructive pulmonary pathology
  publication-title: Thorax
– volume: 66
  start-page: 959
  year: 1998
  end-page: 965
  ident: bib51
  article-title: Human T-cell responses after vaccination with the Norwegian group B meningococcal outer membrane vesicle vaccine
  publication-title: Infect Immun
– volume: 457
  start-page: 722
  year: 2009
  end-page: 725
  ident: bib60
  article-title: A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
  publication-title: Nature
– volume: 30
  start-page: 108
  year: 2009
  end-page: 119
  ident: bib14
  article-title: Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses
  publication-title: Immunity
– volume: 17
  start-page: 1643
  year: 2009
  end-page: 1650
  ident: bib52
  article-title: Lentiviral vectors transduce proliferating dendritic cell precursors leading to persistent antigen presentation and immunization
  publication-title: Mol Ther
– volume: 31
  start-page: 220
  year: 2004
  end-page: 226
  ident: bib61
  article-title: Interleukin-22: a potential immunomodulatory molecule in the lung
  publication-title: Am J Respir Cell Mol Biol
– volume: 203
  start-page: 2271
  year: 2006
  end-page: 2279
  ident: bib33
  article-title: Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
  publication-title: J Exp Med
– volume: 182
  start-page: 5317
  year: 2009
  end-page: 5321
  ident: bib49
  article-title: A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production
  publication-title: J Immunol
– volume: 170
  start-page: 408
  year: 2004
  end-page: 413
  ident: bib40
  article-title: Association of chronic obstructive pulmonary disease severity and
  publication-title: Am J Respir Crit Care Med
– volume: 24
  start-page: 179
  year: 2006
  end-page: 189
  ident: bib20
  article-title: TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
  publication-title: Immunity
– volume: 119
  start-page: 3573
  year: 2009
  end-page: 3585
  ident: bib62
  article-title: Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
  publication-title: J Clin Invest
– volume: 182
  start-page: 4947
  year: 2009
  end-page: 4956
  ident: bib28
  article-title: Lipocalin 2 is required for pulmonary host defense against
  publication-title: J Immunol
– volume: 2
  start-page: 29ra31
  year: 2010
  ident: bib54
  article-title: Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth
  publication-title: Sci Transl Med
– volume: 17
  start-page: 1643
  year: 2009
  ident: 10.1016/j.jaci.2012.05.036_bib52
  article-title: Lentiviral vectors transduce proliferating dendritic cell precursors leading to persistent antigen presentation and immunization
  publication-title: Mol Ther
  doi: 10.1038/mt.2009.149
– volume: 3
  start-page: 811
  year: 1995
  ident: 10.1016/j.jaci.2012.05.036_bib3
  article-title: Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor
  publication-title: Immunity
  doi: 10.1016/1074-7613(95)90070-5
– volume: 30
  start-page: 108
  year: 2009
  ident: 10.1016/j.jaci.2012.05.036_bib14
  article-title: Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses
  publication-title: Immunity
  doi: 10.1016/j.immuni.2008.11.009
– volume: 6
  start-page: 1133
  year: 2005
  ident: 10.1016/j.jaci.2012.05.036_bib19
  article-title: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
  publication-title: Nat Immunol
  doi: 10.1038/ni1261
– volume: 8
  start-page: 829
  year: 2008
  ident: 10.1016/j.jaci.2012.05.036_bib31
  article-title: Cytokine-mediated regulation of antimicrobial proteins
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2433
– volume: 120
  start-page: 3242
  year: 2010
  ident: 10.1016/j.jaci.2012.05.036_bib47
  article-title: Vitamin D3 attenuates Th2 responses to Aspergillus fumigatus mounted by CD4+ T cells from cystic fibrosis patients with allergic bronchopulmonary aspergillosis
  publication-title: J Clin Invest
  doi: 10.1172/JCI42388
– volume: 203
  start-page: 2271
  year: 2006
  ident: 10.1016/j.jaci.2012.05.036_bib33
  article-title: Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
  publication-title: J Exp Med
  doi: 10.1084/jem.20061308
– volume: 202
  start-page: 761
  year: 2005
  ident: 10.1016/j.jaci.2012.05.036_bib11
  article-title: Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
  publication-title: J Exp Med
  doi: 10.1084/jem.20050193
– volume: 6
  start-page: 1123
  year: 2005
  ident: 10.1016/j.jaci.2012.05.036_bib18
  article-title: Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
  publication-title: Nat Immunol
  doi: 10.1038/ni1254
– volume: 136
  start-page: 2348
  year: 1986
  ident: 10.1016/j.jaci.2012.05.036_bib1
  article-title: Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
  publication-title: J Immunol
  doi: 10.4049/jimmunol.136.7.2348
– volume: 2
  start-page: 29ra31
  year: 2010
  ident: 10.1016/j.jaci.2012.05.036_bib54
  article-title: Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth
  publication-title: Sci Transl Med
  doi: 10.1126/scitranslmed.3000928
– volume: 183
  start-page: 2593
  year: 1996
  ident: 10.1016/j.jaci.2012.05.036_bib6
  article-title: T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines
  publication-title: J Exp Med
  doi: 10.1084/jem.183.6.2593
– volume: 14
  start-page: 275
  year: 2008
  ident: 10.1016/j.jaci.2012.05.036_bib44
  article-title: IL-22 mediates mucosal host defense against gram-negative bacterial pneumonia
  publication-title: Nat Med
  doi: 10.1038/nm1710
– volume: 28
  start-page: 29
  year: 2008
  ident: 10.1016/j.jaci.2012.05.036_bib48
  article-title: T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
  publication-title: Immunity
  doi: 10.1016/j.immuni.2007.11.016
– volume: 296
  start-page: L257
  year: 2009
  ident: 10.1016/j.jaci.2012.05.036_bib32
  article-title: Interleukin-17A induces bicarbonate secretion in normal human bronchial epithelial cells
  publication-title: Am J Physiol Lung Cell Mol Physiol
  doi: 10.1152/ajplung.00344.2007
– volume: 97
  start-page: 726
  year: 2003
  ident: 10.1016/j.jaci.2012.05.036_bib22
  article-title: Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine
  publication-title: Respir Med
  doi: 10.1053/rmed.2003.1507
– volume: 157
  start-page: 316
  year: 2009
  ident: 10.1016/j.jaci.2012.05.036_bib25
  article-title: T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients
  publication-title: Clin Exp Immunol
  doi: 10.1111/j.1365-2249.2009.03965.x
– volume: 45
  start-page: 1645
  year: 2010
  ident: 10.1016/j.jaci.2012.05.036_bib72
  article-title: Prognostic significance of genetic variants in the IL-23/Th17 pathway for the outcome of T cell-depleted allogeneic stem cell transplantation
  publication-title: Bone Marrow Transplant
  doi: 10.1038/bmt.2010.28
– volume: 31
  start-page: 220
  year: 2004
  ident: 10.1016/j.jaci.2012.05.036_bib61
  article-title: Interleukin-22: a potential immunomodulatory molecule in the lung
  publication-title: Am J Respir Cell Mol Biol
  doi: 10.1165/rcmb.2003-0285OC
– volume: 182
  start-page: 5317
  year: 2009
  ident: 10.1016/j.jaci.2012.05.036_bib49
  article-title: A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0803868
– year: 2001
  ident: 10.1016/j.jaci.2012.05.036_bib45
  article-title: Isolation of mouse mononuclear cells
– volume: 181
  start-page: 8504
  year: 2008
  ident: 10.1016/j.jaci.2012.05.036_bib34
  article-title: IL-17A enhances vitamin D3-induced expression of cathelicidin antimicrobial peptide in human keratinocytes
  publication-title: J Immunol
  doi: 10.4049/jimmunol.181.12.8504
– volume: 91
  start-page: 27
  year: 2011
  ident: 10.1016/j.jaci.2012.05.036_bib71
  article-title: Treatment With interleukin-12/23p40 antibody attenuates acute cardiac allograft rejection
  publication-title: Transplantation
  doi: 10.1097/TP.0b013e3181fdd948
– volume: 129
  start-page: 311
  year: 2010
  ident: 10.1016/j.jaci.2012.05.036_bib16
  article-title: Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2009.03240.x
– volume: 117
  start-page: 286S
  issue: suppl
  year: 2000
  ident: 10.1016/j.jaci.2012.05.036_bib26
  article-title: Bacterial infection and the pathogenesis of COPD
  publication-title: Chest
  doi: 10.1378/chest.117.5_suppl_1.286S
– volume: 57
  start-page: 759
  year: 2002
  ident: 10.1016/j.jaci.2012.05.036_bib38
  article-title: Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations
  publication-title: Thorax
  doi: 10.1136/thorax.57.9.759
– volume: 183
  start-page: 1577
  year: 2009
  ident: 10.1016/j.jaci.2012.05.036_bib64
  article-title: Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0803803
– volume: 167
  start-page: 1090
  year: 2003
  ident: 10.1016/j.jaci.2012.05.036_bib39
  article-title: Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary disease
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.200210-1179OC
– volume: 100
  start-page: 16083
  year: 2003
  ident: 10.1016/j.jaci.2012.05.036_bib56
  article-title: Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.2634339100
– volume: 5
  start-page: 43
  year: 2008
  ident: 10.1016/j.jaci.2012.05.036_bib41
  article-title: Pneumocystis: a novel pathogen in chronic obstructive pulmonary disease?
  publication-title: COPD
  doi: 10.1080/15412550701817656
– volume: 37
  start-page: 2695
  year: 2007
  ident: 10.1016/j.jaci.2012.05.036_bib58
  article-title: IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance
  publication-title: Eur J Immunol
  doi: 10.1002/eji.200737409
– volume: 175
  start-page: 404
  year: 2005
  ident: 10.1016/j.jaci.2012.05.036_bib24
  article-title: Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-α and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis
  publication-title: J Immunol
  doi: 10.4049/jimmunol.175.1.404
– volume: 185
  start-page: 3417
  year: 2010
  ident: 10.1016/j.jaci.2012.05.036_bib69
  article-title: Critical role of regulatory T cells in Th17-mediated minor antigen-disparate rejection
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0903961
– volume: 170
  start-page: 408
  year: 2004
  ident: 10.1016/j.jaci.2012.05.036_bib40
  article-title: Association of chronic obstructive pulmonary disease severity and Pneumocystis colonization
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.200401-094OC
– volume: 127
  start-page: 1006
  year: 2011
  ident: 10.1016/j.jaci.2012.05.036_bib50
  article-title: Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production
  publication-title: Journal Allergy Clin Immunol
  doi: 10.1016/j.jaci.2010.11.043
– volume: 24
  start-page: 179
  year: 2006
  ident: 10.1016/j.jaci.2012.05.036_bib20
  article-title: TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2006.01.001
– volume: 285
  start-page: 14088
  year: 2010
  ident: 10.1016/j.jaci.2012.05.036_bib30
  article-title: Induction of neutrophil gelatinase-associated lipocalin expression by co-stimulation with interleukin-17 and tumor necrosis factor-alpha is controlled by IkappaB-zeta but neither by C/EBP-beta nor C/EBP-delta
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.017129
– volume: 207
  start-page: 291
  year: 2010
  ident: 10.1016/j.jaci.2012.05.036_bib21
  article-title: Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I
  publication-title: J Exp Med
  doi: 10.1084/jem.20091983
– volume: 184
  start-page: 5344
  year: 2010
  ident: 10.1016/j.jaci.2012.05.036_bib68
  article-title: Intragraft Th17 infiltrate promotes lymphoid neogenesis and hastens clinical chronic rejection
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0902999
– volume: 25
  start-page: E177
  year: 2011
  ident: 10.1016/j.jaci.2012.05.036_bib70
  article-title: Dynamic changes in Th1, Th17, and FoxP3(+) T cells in patients with acute cellular rejection after cardiac transplantation
  publication-title: Clin Transplant
  doi: 10.1111/j.1399-0012.2010.01362.x
– volume: 441
  start-page: 235
  year: 2006
  ident: 10.1016/j.jaci.2012.05.036_bib17
  article-title: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
  publication-title: Nature
  doi: 10.1038/nature04753
– volume: 20
  start-page: 35
  year: 2006
  ident: 10.1016/j.jaci.2012.05.036_bib57
  article-title: The mammalian ionic environment dictates microbial susceptibility to antimicrobial defense peptides
  publication-title: FASEB J
  doi: 10.1096/fj.05-4406com
– volume: 21
  start-page: 387
  year: 2003
  ident: 10.1016/j.jaci.2012.05.036_bib8
  article-title: A role of GM-CSF in the accumulation of neutrophils in the airways caused by IL-17 and TNF-alpha
  publication-title: Eur Respir J
  doi: 10.1183/09031936.03.00303503
– volume: 25
  start-page: 335
  year: 2001
  ident: 10.1016/j.jaci.2012.05.036_bib10
  article-title: Interleukin-17 and lung host defense against Klebsiella pneumoniae infection
  publication-title: Am J Respir Cell Mol Biol
  doi: 10.1165/ajrcmb.25.3.4424
– volume: 457
  start-page: 722
  year: 2009
  ident: 10.1016/j.jaci.2012.05.036_bib60
  article-title: A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
  publication-title: Nature
  doi: 10.1038/nature07537
– volume: 109
  start-page: 3794
  year: 2007
  ident: 10.1016/j.jaci.2012.05.036_bib27
  article-title: An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals
  publication-title: Blood
  doi: 10.1182/blood-2005-09-010116
– volume: 26
  start-page: 52
  year: 2002
  ident: 10.1016/j.jaci.2012.05.036_bib36
  article-title: Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response
  publication-title: Am J Respir Cell Mol Biol
  doi: 10.1165/ajrcmb.26.1.4253
– volume: 25
  start-page: 437
  year: 2005
  ident: 10.1016/j.jaci.2012.05.036_bib66
  article-title: The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretion
  publication-title: J Clin Immunol
  doi: 10.1007/s10875-005-5625-6
– volume: 83
  start-page: 525
  year: 2005
  ident: 10.1016/j.jaci.2012.05.036_bib65
  article-title: Differential expression of inflammatory chemokines by Th1- and Th2-cell promoting dendritic cells: a role for different mature dendritic cell populations in attracting appropriate effector cells to peripheral sites of inflammation
  publication-title: Immunol Cell Biol
  doi: 10.1111/j.1440-1711.2005.01365.x
– volume: 119
  start-page: 3573
  year: 2009
  ident: 10.1016/j.jaci.2012.05.036_bib62
  article-title: Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
  publication-title: J Clin Invest
– volume: 173
  start-page: 3482
  year: 2004
  ident: 10.1016/j.jaci.2012.05.036_bib29
  article-title: IL-17 Markedly up-regulates β-defensin-2 expression in human airway epithelium via JAK and NF-κB signaling pathways
  publication-title: J Immunol
  doi: 10.4049/jimmunol.173.5.3482
– volume: 61
  start-page: 259
  year: 2006
  ident: 10.1016/j.jaci.2012.05.036_bib42
  article-title: Matrix metalloproteinases in destructive pulmonary pathology
  publication-title: Thorax
  doi: 10.1136/thx.2005.051979
– volume: 155
  start-page: 5483
  year: 1995
  ident: 10.1016/j.jaci.2012.05.036_bib4
  article-title: Human IL-17: a novel cytokine derived from T cells
  publication-title: J Immunol
  doi: 10.4049/jimmunol.155.12.5483
– volume: 111
  start-page: 1293
  year: 2003
  ident: 10.1016/j.jaci.2012.05.036_bib23
  article-title: Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression
  publication-title: J Allergy Clin Immunol
  doi: 10.1067/mai.2003.1557
– volume: 451
  start-page: 211
  year: 2008
  ident: 10.1016/j.jaci.2012.05.036_bib55
  article-title: Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
  publication-title: Nature
  doi: 10.1038/nature06471
– volume: 173
  start-page: 1114
  year: 2006
  ident: 10.1016/j.jaci.2012.05.036_bib37
  article-title: Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.200506-859OC
– volume: 13
  start-page: 310
  year: 2006
  ident: 10.1016/j.jaci.2012.05.036_bib53
  article-title: Immunization with a lentiviral vector stimulates both CD4 and CD8 T cell responses to an ovalbumin transgene
  publication-title: Mol Ther
  doi: 10.1016/j.ymthe.2005.08.025
– volume: 206
  start-page: 299
  year: 2009
  ident: 10.1016/j.jaci.2012.05.036_bib15
  article-title: Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
  publication-title: J Exp Med
  doi: 10.1084/jem.20081463
– year: 2001
  ident: 10.1016/j.jaci.2012.05.036_bib46
  article-title: Isolation of mouse small intestinal intraepithelial lymphocytes, peyer's patch, and lamina propria cells
– volume: 66
  start-page: 959
  year: 1998
  ident: 10.1016/j.jaci.2012.05.036_bib51
  article-title: Human T-cell responses after vaccination with the Norwegian group B meningococcal outer membrane vesicle vaccine
  publication-title: Infect Immun
  doi: 10.1128/IAI.66.3.959-965.1998
– volume: 292
  start-page: L519
  year: 2007
  ident: 10.1016/j.jaci.2012.05.036_bib59
  article-title: IL-23 mediates inflammatory responses to mucoid Pseudomonas aeruginosa lung infection in mice
  publication-title: Am J Physiol Lung Cell Mol Physiol
  doi: 10.1152/ajplung.00312.2006
– volume: 88
  start-page: 1341
  year: 2009
  ident: 10.1016/j.jaci.2012.05.036_bib67
  article-title: Transfer of tolerance to collagen type V suppresses T-helper-cell-17 lymphocyte-mediated acute lung transplant rejection
  publication-title: Transplantation
  doi: 10.1097/TP.0b013e3181bcde7b
– volume: 77
  start-page: 388
  year: 2005
  ident: 10.1016/j.jaci.2012.05.036_bib35
  article-title: Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-α-induced genes in bone cells
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.0904490
– volume: 182
  start-page: 4947
  year: 2009
  ident: 10.1016/j.jaci.2012.05.036_bib28
  article-title: Lipocalin 2 is required for pulmonary host defense against Klebsiella infection
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0803282
– volume: 194
  start-page: 519
  year: 2001
  ident: 10.1016/j.jaci.2012.05.036_bib9
  article-title: Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
  publication-title: J Exp Med
  doi: 10.1084/jem.194.4.519
– volume: 441
  start-page: 231
  year: 2006
  ident: 10.1016/j.jaci.2012.05.036_bib13
  article-title: Transforming growth factor-beta induces development of the T(H)17 lineage
  publication-title: Nature
  doi: 10.1038/nature04754
– volume: 65
  start-page: 5052
  year: 1997
  ident: 10.1016/j.jaci.2012.05.036_bib2
  article-title: Protection against Pneumocystis carinii pneumonia by antibodies generated from either T helper 1 or T helper 2 responses
  publication-title: Infect Immun
  doi: 10.1128/IAI.65.12.5052-5056.1997
– volume: 162
  start-page: 2347
  year: 1999
  ident: 10.1016/j.jaci.2012.05.036_bib7
  article-title: Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways
  publication-title: J Immunol
  doi: 10.4049/jimmunol.162.4.2347
– volume: 150
  start-page: 5445
  year: 1993
  ident: 10.1016/j.jaci.2012.05.036_bib5
  article-title: CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus Saimiri gene
  publication-title: J Immunol
  doi: 10.4049/jimmunol.150.12.5445
– volume: 4
  start-page: 617
  year: 2004
  ident: 10.1016/j.jaci.2012.05.036_bib43
  article-title: Matrix metalloproteinases as modulators of inflammation and innate immunity
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri1418
– volume: 14
  start-page: 421
  year: 2008
  ident: 10.1016/j.jaci.2012.05.036_bib12
  article-title: Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut
  publication-title: Nat Med
  doi: 10.1038/nm1743
– volume: 1
  start-page: 4ra10
  year: 2009
  ident: 10.1016/j.jaci.2012.05.036_bib63
  article-title: Lung myeloid dendritic cells coordinately induce TH1 and TH17 responses in human emphysema
  publication-title: Sci Transl Med
  doi: 10.1126/scitranlsmed.3000154
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Snippet IL-17 is an important cytokine signature of the TH differentiation pathway TH17. This T-cell subset is crucial in mediating autoimmune disease or antimicrobial...
Background IL-17 is an important cytokine signature of the TH differentiation pathway TH 17. This T-cell subset is crucial in mediating autoimmune disease or...
Background IL-17 is an important cytokine signature of the THdifferentiation pathway TH17. This T-cell subset is crucial in mediating autoimmune disease or...
BACKGROUND: IL-17 is an important cytokine signature of the TH differentiation pathway TH17. This T-cell subset is crucial in mediating autoimmune disease or...
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SubjectTerms Adult
Aged
Allergy and Immunology
animal models
Antigens
Antigens, Bacterial - immunology
Antigens, Bacterial - pharmacology
Antigens, Fungal - immunology
Antigens, Fungal - pharmacology
Aspergillus
Aspergillus - chemistry
Aspergillus species
autoimmune diseases
Biological and medical sciences
Case-Control Studies
Cell Proliferation - drug effects
chronic infectious disease
Chronic obstructive pulmonary disease
Cystic fibrosis
Cystic Fibrosis - genetics
Cystic Fibrosis - immunology
Cystic Fibrosis - pathology
Disease
Errors of metabolism
Female
flow cytometry
fluorescent antibody technique
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Fungal infections
Gene Expression
human diseases
Human subjects
Humans
IL-17
IL-22
Immune system
immunity
Immunologic Memory
Immunopathology
Immunophenotyping
interleukin-17
Interleukin-17 - genetics
Interleukin-17 - immunology
Interleukin-22
Interleukins - genetics
Interleukins - immunology
Lung - drug effects
Lung - immunology
Lung - pathology
lung transplant
Lungs
lymph nodes
Lymph Nodes - drug effects
Lymph Nodes - immunology
Lymph Nodes - pathology
Lymphocyte Activation - drug effects
Male
Medical sciences
memory T-cell response
Metabolic diseases
Middle Aged
Miscellaneous hereditary metabolic disorders
organ transplantation
pathogens
patients
phenotype
Pseudomonas aeruginosa
Pseudomonas aeruginosa - chemistry
Pseudomonas species
quantitative polymerase chain reaction
Review boards
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Studies
T-lymphocytes
TH17
Th17 Cells - drug effects
Th17 Cells - immunology
Th17 Cells - pathology
TH22
Transplants & implants
Title Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes
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Volume 131
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