Recent synthetic efforts in the preparation of 2-(3,4)-alkenyl (aryl) quinoline molecules towards anti-kinetoplastid agents

• Published in: RSC advances Vol. 1; no. 9; pp. 4876 - 4898
• Main Authors: Orozco, Dayana, Kouznetsov, Vladimir V, Bermúdez, Armando, Vargas Méndez, Leonor Y, Mendoza Salgado, Arturo René, Meléndez Gómez, Carlos Mario
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 29.01.2020; The Royal Society of Chemistry
• Subjects: Alkaloids; antiprotozoal properties; Aromatic compounds; Chagas disease; Chemical synthesis; Chemistry; cost effectiveness; drug design; Drugs; humans; Illnesses; Leishmania; leishmaniasis; Organic chemistry; Organic compounds; Parasitic diseases; Protozoa; pyridines; quinine; Quinoline; Schedules; Tropical diseases; Trypanosoma

Leishmaniasis, Chagas disease and African sleeping sickness have been considered some of the most important tropical protozoan afflictions. As the number of drugs currently available to treat these human illnesses is severely limited and the majority has poor safety profiles and complicated administ...