Durability of Vaccine-Induced Immunity Against Tetanus and Diphtheria Toxins: A Cross-sectional Analysis

• Published in: Clinical infectious diseases Vol. 62; no. 9; pp. 1111 - 1118
• Main Authors: Hammarlund, Erika, Thomas, Archana, Poore, Elizabeth A., Amanna, Ian J., Rynko, Abby E., Mori, Motomi, Chen, Zunqiu, Slifka, Mark K.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.05.2016
• Subjects: Adult; Adults; Aged; Aged, 80 and over; and Commentaries; Antibodies, Bacterial - blood; Antibody Formation; ARTICLES AND COMMENTARIES; Cross-Sectional Studies; Diphtheria; Diphtheria Toxin - immunology; Diphtheria-Tetanus Vaccine; Female; Half-Life; Humans; Immunity (Disease); Immunization Schedule; Immunization, Secondary; Male; Middle Aged; Tetanus; Tetanus Toxin - immunology; Toxins; Vaccines; Young Adult; cross-sectional analysis; tetanus; diphtheria; immunological memory

Background. Many adult immunization schedules recommend that tetanus and diphtheria vaccination be performed every 10 years. In light of current epidemiological trends of disease incidence and rates of vaccine-associated adverse events, the 10-year revaccination schedule has come into question. Meth...