Role of the kynurenine pathway and the endocannabinoid system as modulators of inflammation and personality traits
•IL-6, 2-AG, and KP metabolites in people with/without mood, anxiety, and personality disorder were correlated with measures of personality.•IL-6 levels were significantly associated with plasma 2-AG levels and plasma picolinic acid levels which correlated inversely with 2-AG levels across all subje...
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| Published in | Psychoneuroendocrinology Vol. 110; p. 104434 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.12.2019
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0306-4530 1873-3360 1873-3360 |
| DOI | 10.1016/j.psyneuen.2019.104434 |
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| Abstract | •IL-6, 2-AG, and KP metabolites in people with/without mood, anxiety, and personality disorder were correlated with measures of personality.•IL-6 levels were significantly associated with plasma 2-AG levels and plasma picolinic acid levels which correlated inversely with 2-AG levels across all subjects, independent of IL-6.•We also identified associations between IL-6 and novelty seeking, and between PIC and neuroticism.•These data provide evidence of a link between IL-6, endocannabinoids, and KP metabolites and suggest that these factors influence personality traits.
Kynurenine pathway metabolites and endocannabinoids both exert potent regulatory effects on the immune system, but the relationship between these molecules is unknown. The role of these immunobiological mediators in emotionality and personality traits is not previously characterized.
Interleukin-6 (IL-6), 2-arachidonoylglycerol (2-AG) and picolinic acid (PIC) were measured in the plasma of physically healthy individuals who had history of mood, anxiety, and personality disorders (n = 96) or who had no history of any psychiatric disorder (n = 56) by DSM-5 Criteria. Dimensional assessments of personality were performed using the Eysenck Personality Questionnaire (EPQ) and the Tridimensional Personality Questionnaire (TPQ).
Plasma IL-6 levels were significantly associated with plasma 2-AG levels and plasma PIC levels across all subjects. PIC levels were also negatively associated with 2-AG levels across all subjects, independent of IL-6 levels. In our analysis of the biological determinants of personality factors, we identified significant associations between IL-6 and novelty seeking assessment, and between PIC and neuroticism assessment.
These data provide evidence of a biological link between metabolites of the kynurenine pathway, the endocannabinoid system and IL-6 and suggest that these factors may influence personality traits. |
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| AbstractList | Kynurenine pathway metabolites and endocannabinoids both exert potent regulatory effects on the immune system, but the relationship between these molecules is unknown. The role of these immunobiological mediators in emotionality and personality traits is not previously characterized.BACKGROUNDKynurenine pathway metabolites and endocannabinoids both exert potent regulatory effects on the immune system, but the relationship between these molecules is unknown. The role of these immunobiological mediators in emotionality and personality traits is not previously characterized.Interleukin-6 (IL-6), 2-arachidonoylglycerol (2-AG) and picolinic acid (PIC) were measured in the plasma of physically healthy individuals who had history of mood, anxiety, and personality disorders (n = 96) or who had no history of any psychiatric disorder (n = 56) by DSM-5 Criteria. Dimensional assessments of personality were performed using the Eysenck Personality Questionnaire (EPQ) and the Tridimensional Personality Questionnaire (TPQ).METHODSInterleukin-6 (IL-6), 2-arachidonoylglycerol (2-AG) and picolinic acid (PIC) were measured in the plasma of physically healthy individuals who had history of mood, anxiety, and personality disorders (n = 96) or who had no history of any psychiatric disorder (n = 56) by DSM-5 Criteria. Dimensional assessments of personality were performed using the Eysenck Personality Questionnaire (EPQ) and the Tridimensional Personality Questionnaire (TPQ).Plasma IL-6 levels were significantly associated with plasma 2-AG levels and plasma PIC levels across all subjects. PIC levels were also negatively associated with 2-AG levels across all subjects, independent of IL-6 levels. In our analysis of the biological determinants of personality factors, we identified significant associations between IL-6 and novelty seeking assessment, and between PIC and neuroticism assessment.RESULTSPlasma IL-6 levels were significantly associated with plasma 2-AG levels and plasma PIC levels across all subjects. PIC levels were also negatively associated with 2-AG levels across all subjects, independent of IL-6 levels. In our analysis of the biological determinants of personality factors, we identified significant associations between IL-6 and novelty seeking assessment, and between PIC and neuroticism assessment.These data provide evidence of a biological link between metabolites of the kynurenine pathway, the endocannabinoid system and IL-6 and suggest that these factors may influence personality traits.CONCLUSIONSThese data provide evidence of a biological link between metabolites of the kynurenine pathway, the endocannabinoid system and IL-6 and suggest that these factors may influence personality traits. •IL-6, 2-AG, and KP metabolites in people with/without mood, anxiety, and personality disorder were correlated with measures of personality.•IL-6 levels were significantly associated with plasma 2-AG levels and plasma picolinic acid levels which correlated inversely with 2-AG levels across all subjects, independent of IL-6.•We also identified associations between IL-6 and novelty seeking, and between PIC and neuroticism.•These data provide evidence of a link between IL-6, endocannabinoids, and KP metabolites and suggest that these factors influence personality traits. Kynurenine pathway metabolites and endocannabinoids both exert potent regulatory effects on the immune system, but the relationship between these molecules is unknown. The role of these immunobiological mediators in emotionality and personality traits is not previously characterized. Interleukin-6 (IL-6), 2-arachidonoylglycerol (2-AG) and picolinic acid (PIC) were measured in the plasma of physically healthy individuals who had history of mood, anxiety, and personality disorders (n = 96) or who had no history of any psychiatric disorder (n = 56) by DSM-5 Criteria. Dimensional assessments of personality were performed using the Eysenck Personality Questionnaire (EPQ) and the Tridimensional Personality Questionnaire (TPQ). Plasma IL-6 levels were significantly associated with plasma 2-AG levels and plasma PIC levels across all subjects. PIC levels were also negatively associated with 2-AG levels across all subjects, independent of IL-6 levels. In our analysis of the biological determinants of personality factors, we identified significant associations between IL-6 and novelty seeking assessment, and between PIC and neuroticism assessment. These data provide evidence of a biological link between metabolites of the kynurenine pathway, the endocannabinoid system and IL-6 and suggest that these factors may influence personality traits. Kynurenine pathway metabolites and endocannabinoids both exert potent regulatory effects on the immune system, but the relationship between these molecules is unknown. The role of these immunobiological mediators in emotionality and personality traits is not previously characterized. Interleukin-6 (IL-6), 2-arachidonoylglycerol (2-AG) and picolinic acid (PIC) were measured in the plasma of physically healthy individuals who had history of mood, anxiety, and personality disorders (n = 96) or who had no history of any psychiatric disorder (n = 56) by DSM-5 Criteria. Dimensional assessments of personality were performed using the Eysenck Personality Questionnaire (EPQ) and the Tridimensional Personality Questionnaire (TPQ). Plasma IL-6 levels were significantly associated with plasma 2-AG levels and plasma PIC levels across all subjects. PIC levels were also negatively associated with 2-AG levels across all subjects, independent of IL-6 levels. In our analysis of the biological determinants of personality factors, we identified significant associations between IL-6 and novelty seeking assessment, and between PIC and neuroticism assessment. These data provide evidence of a biological link between metabolites of the kynurenine pathway, the endocannabinoid system and IL-6 and suggest that these factors may influence personality traits. |
| ArticleNumber | 104434 |
| Author | Brundin, Lena Coussons-Read, Mary Heilman, Patrick Hill, Matthew N. Coccaro, Emil F. |
| AuthorAffiliation | Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB Canada Department of Psychology, University of Denver at Colorado Springs, Colorado Springs, CO Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan Division of Psychiatry and Behavioral Medicine, College of Human Medicine, Michigan State University Clinical Neuroscience Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, University of Chicago, Chicago, IL |
| AuthorAffiliation_xml | – name: Division of Psychiatry and Behavioral Medicine, College of Human Medicine, Michigan State University – name: Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB Canada – name: Department of Psychology, University of Denver at Colorado Springs, Colorado Springs, CO – name: Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan – name: Clinical Neuroscience Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, University of Chicago, Chicago, IL |
| Author_xml | – sequence: 1 givenname: Patrick surname: Heilman fullname: Heilman, Patrick organization: Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, United States – sequence: 2 givenname: Matthew N. surname: Hill fullname: Hill, Matthew N. organization: Hotchkiss Brain Institute and Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, Canada – sequence: 3 givenname: Mary surname: Coussons-Read fullname: Coussons-Read, Mary organization: Department of Psychology, University of Denver at Colorado Springs, Colorado Springs, CO, United States – sequence: 4 givenname: Lena surname: Brundin fullname: Brundin, Lena organization: Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI, United States – sequence: 5 givenname: Emil F. surname: Coccaro fullname: Coccaro, Emil F. email: ecoccaro@bsd.uchicago.edu organization: Clinical Neuroscience Research Unit, Department of Psychiatry and Behavioral Neuroscience, Pritzker School of Medicine, University of Chicago, Chicago, IL, United States |
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| Keywords | Neuroticism Reward dependence Picolinic acid 2-Arachidonoylglycerol Interleukin-6 |
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| Snippet | •IL-6, 2-AG, and KP metabolites in people with/without mood, anxiety, and personality disorder were correlated with measures of personality.•IL-6 levels were... Kynurenine pathway metabolites and endocannabinoids both exert potent regulatory effects on the immune system, but the relationship between these molecules is... |
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| SubjectTerms | 2-Arachidonoylglycerol Adult Anxiety Disorders - blood Anxiety Disorders - epidemiology Anxiety Disorders - etiology Arachidonic Acids - blood Cohort Studies Endocannabinoids - blood Endocannabinoids - metabolism Endocannabinoids - physiology Female Glycerides - blood Humans Inflammation - epidemiology Inflammation - etiology Inflammation - metabolism Interleukin-6 Interleukin-6 - blood Kynurenine - metabolism Kynurenine - physiology Male Middle Aged Neuroticism Personality - physiology Personality Disorders - blood Personality Disorders - epidemiology Personality Disorders - etiology Picolinic acid Picolinic Acids - blood Receptors, Cannabinoid - metabolism Receptors, Cannabinoid - physiology Reward dependence Signal Transduction - physiology |
| Title | Role of the kynurenine pathway and the endocannabinoid system as modulators of inflammation and personality traits |
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