Transferable Immunoglobulin A–Coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 162; no. 1; pp. 166 - 178
• Main Authors: Lima, Svetlana F., Gogokhia, Lasha, Viladomiu, Monica, Chou, Lance, Putzel, Gregory, Jin, Wen-Bing, Pires, Silvia, Guo, Chun-Jun, Gerardin, Ylaine, Crawford, Carl V., Jacob, Vinita, Scherl, Ellen, Brown, Su-Ellen, Hambor, John, Longman, Randy S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2022
• Subjects: Animals; Bacteroidetes - genetics; Bacteroidetes - immunology; Bacteroidetes - metabolism; Clinical Trials as Topic; Colitis - immunology; Colitis - metabolism; Colitis - microbiology; Colitis - therapy; Colitis, Ulcerative - diagnosis; Colitis, Ulcerative - immunology; Colitis, Ulcerative - metabolism; Colitis, Ulcerative - microbiology; Colon - immunology; Colon - metabolism; Colon - microbiology; Disease Models, Animal; Fecal Microbiota Transplant; Fecal Microbiota Transplantation; Forkhead Transcription Factors - metabolism; Gastrointestinal Microbiome - genetics; Gastrointestinal Microbiome - immunology; Germ-Free Life; Humans; IgA-Seq; Immunity, Mucosal; Immunoglobulin A - genetics; Immunoglobulin A - immunology; Immunoglobulin A - metabolism; Intestinal Mucosa - immunology; Intestinal Mucosa - metabolism; Intestinal Mucosa - microbiology; Intraepithelial Lymphocytes - immunology; Intraepithelial Lymphocytes - metabolism; Intraepithelial Lymphocytes - microbiology; Metagenome; Metagenomics; Mice; Mice, Inbred C57BL; Mice, Knockout; Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism; Odoribacter; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; T-Lymphocytes, Regulatory - microbiology; Treatment Outcome; Ulcerative Colitis; PRE; TCR; Odoribacter; IBD; RTM; UC; AUC; Ulcerative Colitis; het; NRTM; WT; WK4; DON; IL; ASV; DSS; IgA-Seq; rRNA; Fecal Microbiota Transplant; ROC; FMP; FMT; SCFA; LPMC; MES; SEM; CTM

Fecal microbiota transplantation (FMT) is an emerging treatment modality for ulcerative colitis (UC). Several randomized controlled trials have shown efficacy for FMT in the treatment of UC, but a better understanding of the transferable microbiota and their immune impact is needed to develop more e...