Interferon and TLR genes, but not endogenous bornavirus-like elements, limit BoDV1 replication after intracerebral infection

• Published in: PLoS pathogens Vol. 21; no. 5; p. e1013165
• Main Authors: Koide, Rie, Abe, Takaya, Harimoto, Taichi, Kamada, Anselmo Jiro, Saito, Yuka, Guerrini, Matteo, Fujii, Asami, Parrish, Erica, Horie, Masayuki, Kiyonari, Hiroshi, Yamamoto, Kazuhiko, Tomonaga, Keizo, Parrish, Nicholas F
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.05.2025; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Antiviral agents; Biology and Life Sciences; Borna Disease - genetics; Borna Disease - immunology; Borna Disease - virology; Borna disease virus - genetics; Borna disease virus - immunology; Borna disease virus - physiology; Brain - immunology; Brain - virology; Control; Dosage and administration; Engineering and Technology; Genetic aspects; Identification and classification; Immunity, Innate; Interferon; Interferon-gamma - genetics; Interferon-gamma - immunology; Medicine and Health Sciences; Membrane Glycoproteins - genetics; Membrane Glycoproteins - immunology; Mice; Mice, Inbred C57BL; Mice, Knockout; Research and Analysis Methods; RNA viruses; RNA, Small Interfering - genetics; RNA, Small Interfering - immunology; Toll-Like Receptor 7 - genetics; Toll-Like Receptor 7 - immunology; Toll-like receptors; Virus Replication - genetics; Virus Replication - immunology; Japan

Borna disease virus 1 (BoDV1) is a disease-causing agent in some livestock and, as has recently been shown, in humans. What constitutes a protective immune response to BoDV1 is unclear. Previous studies found that endogenous bornavirus-like nucleoprotein elements (EBLNs) present in mammalian genomes...