Symbionts exploit complex signaling to educate the immune system

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 52; pp. 26157 - 26166
• Main Authors: Erturk-Hasdemir, Deniz, Oh, Sungwhan F., Okan, Nihal A., Stefanetti, Giuseppe, Gazzaniga, Francesca S., Seeberger, Peter H., Plevy, Scott E., Kasper, Dennis L.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 26.12.2019
• Series: Inaugural Article
• Subjects: Biological Sciences; INAUGURAL ARTICLE; host–microbe interactions; Bacteroides fragilis; symbionts; polysaccharide A; zwitterionic polysaccharides (ZPSs)

The mammalian immune system is tolerized to trillions of microbes residing on bodily surfaces and can discriminate between symbionts and pathogens despite their having related microbial structures. Mechanisms of innate immune activation and the subsequent signaling pathways used by symbionts to comm...