PKIDB: A Curated, Annotated and Updated Database of Protein Kinase Inhibitors in Clinical Trials

• Published in: Molecules (Basel, Switzerland) Vol. 23; no. 4; p. 908
• Main Authors: Carles, Fabrice, Bourg, Stéphane, Meyer, Christophe, Bonnet, Pascal
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.04.2018; MDPI
• Subjects: approved drugs; Binding Sites; Chemical Sciences; Cheminformatics; chemometrics analysis; Clinical trials; Clinical Trials as Topic; Cyclin-dependent kinases; Databases as Topic; Drug Approval; Kinases; kinome; Models, Molecular; Pharmaceutical industry; Principal Component Analysis; Principal components analysis; Protease inhibitors; protein kinase inhibitors; Protein Kinase Inhibitors - pharmacology; Proteins; database; chemometrics analysis; clinical trials; approved drugs; kinome; protein kinase inhibitors

The number of protein kinase inhibitors (PKIs) approved worldwide continues to grow steadily, with 39 drugs approved in the period between 2001 and January 2018. PKIs on the market have been the subject of many reviews, and structure-property relationships specific to this class of drugs have been i...