Intestinal Barrier Healing Is Superior to Endoscopic and Histologic Remission for Predicting Major Adverse Outcomes in Inflammatory Bowel Disease: The Prospective ERIca Trial

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 164; no. 2; pp. 241 - 255
• Main Authors: Rath, Timo, Atreya, Raja, Bodenschatz, Julia, Uter, Wolfgang, Geppert, Carol E., Vitali, Francesco, Fischer, Sarah, Waldner, Maximilian J., Colombel, Jean-Frédéric, Hartmann, Arndt, Neurath, Markus F.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2023
• Subjects: Colitis, Ulcerative - diagnosis; Colitis, Ulcerative - drug therapy; Confocal Laser Endomicroscopy; Crohn Disease - drug therapy; Endoscopy; Histology; Humans; Inflammatory Bowel Diseases; Inflammatory Bowel Diseases - diagnosis; Inflammatory Bowel Diseases - drug therapy; Intestinal Barrier; Prospective Studies; Remission Induction; Severity of Illness Index; CRP; CD; IO-IBD; Inflammatory Bowel Diseases; Intestinal Barrier; Confocal Laser Endomicroscopy; mRiley; Histology; IBD; NHI; UC; STRIDE; RHI; CDAI; SES-CD; MAO; MES; Endoscopy; MCS; CLE; pCLE

Endoscopic and histologic remission have emerged as key therapeutic goals in the management of inflammatory bowel diseases (IBD) that are associated with favorable long-term disease outcomes. Here, we prospectively compared the predictive value of barrier healing with endoscopic and histologic remis...