Revealing underlying regulatory mechanisms of LINC00313 in Osimertinib-resistant LUAD cells by ceRNA network analysis

• Published in: Translational oncology Vol. 43; p. 101895
• Main Authors: Ding, Dandan, Xu, Chenguang, Zhang, Jufeng, Zhang, Ying, Xue, Lipeng, Song, Jingjing, Luo, Zhiming, Hong, Xiaoyu, Wang, Jian, Liang, Weicheng, Xue, Xingyang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2024; Elsevier
• Subjects: EGFR-TKIs; LINC00313; lncRNA-miRNA-mRNA (ceRNA); Lung adenocarcinoma (LUAD); Osimertinib resistance; EGFR-TKIs; Osimertinib resistance; Lung adenocarcinoma (LUAD); lncRNA-miRNA-mRNA (ceRNA); LINC00313

•The LINC00313/miR-218-5p/COL1A1 axis is proposed as a ceRNA regulatory mechanism that contributes to the development of acquired resistance to osimertinib in LUAD via the PI3K/Akt pathway.•Some newly identified target DE-mRNAs, regulated by LINC00313, function as potential risk signatures for predi...