Engaging cervical spinal circuitry with non-invasive spinal stimulation and buspirone to restore hand function in chronic motor complete patients

• Published in: Scientific reports Vol. 8; no. 1; pp. 15546 - 10
• Main Authors: Freyvert, Yevgeniy, Yong, Nicholas Au, Morikawa, Erika, Zdunowski, Sharon, Sarino, Melanie E., Gerasimenko, Yury, Edgerton, V. Reggie, Lu, Daniel C.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.10.2018; Nature Publishing Group
• Subjects: 631/378/1689; 692/699/375/1824; 692/699/578; Adolescent; Adult; Buspirone; Buspirone - administration & dosage; Clinical trials; Combined Modality Therapy; Contraction; Electric Stimulation Therapy; Electrical stimuli; Electrodes; Electromyography; Epidural; Evoked Potentials, Motor; Female; Hand; Hand - physiology; Hand Strength; Humanities and Social Sciences; Humans; Male; Movement; multidisciplinary; Neck Injuries - therapy; Paralysis; Physiology; Recovery of Function; Rehabilitation; Science; Science (multidisciplinary); Serotonin Receptor Agonists - administration & dosage; Spinal cord injuries; Spinal Cord Injuries - therapy; Substance abuse treatment; Variance analysis; Young Adult; Handgrip Force; Action Research Arm Test (ARAT); Hand Contractures; ARAT Scores; Hand Strength

The combined effects of cervical electrical stimulation alone or in combination with the monoaminergic agonist buspirone on upper limb motor function were determined in six subjects with motor complete (AIS B) injury at C5 or above and more than one year from time of injury. Voluntary upper limb fun...