Testosterone therapy and breast histopathological features in transgender individuals

• Published in: Modern pathology Vol. 34; no. 1; pp. 85 - 94
• Main Authors: Baker, Gabrielle M., Guzman-Arocho, Yaileen D., Bret-Mounet, Vanessa C., Torous, Vanda F., Schnitt, Stuart J., Tobias, Adam M., Bartlett, Richard A., Fein-Zachary, Valerie J., Collins, Laura C., Wulf, Gerburg M., Heng, Yujing J.
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.01.2021; Nature Publishing Group US; Elsevier Limited
• Subjects: 14/63; 692/308/575; 692/699/67/1347; 692/700/139/422; Adult; Androgens - adverse effects; Atrophy; Body mass index; Breast - drug effects; Breast cancer; Breast Diseases - chemically induced; Cancer screening; Chest; Cysts; Endocrine therapy; Female; Fibroadenoma; Gender; Gender nonconforming; Humans; Hyperplasia; Laboratory Medicine; Male; Medical screening; Medicine; Medicine & Public Health; Ovariectomy; Pathology; Retrospective Studies; Sex Reassignment Surgery; Surgery; Testosterone; Testosterone - adverse effects; Transgender Persons

Testosterone therapy (TT) is administered to enhance masculinization in transgender individuals. The long-term effect of exogenous testosterone on breast tissues remains unclear. Our study evaluated the modulation of breast morphology by TT in transgender individuals with special attention to durati...