Systemically inoculated adjuvants stimulate pDC-dependent IgA response in local site

• Published in: Mucosal immunology Vol. 16; no. 3; pp. 275 - 286
• Main Authors: Sasaki, Eita, Asanuma, Hideki, Momose, Haruka, Furuhata, Keiko, Mizukami, Takuo, Matsumura, Takayuki, Takahashi, Yoshimasa, Hamaguchi, Isao
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2023
• Subjects: Adjuvants, Immunologic; Administration, Intranasal; Animals; Antibodies, Viral; Dendritic Cells; Immunity, Mucosal; Immunoglobulin A; Immunoglobulin G; Influenza Vaccines; Interferon Type I; Mice; Mice, Inbred BALB C

The stimulation of local immunity by vaccination is desirable for controlling virus replication in the respiratory tract. However, the local immune stimulatory effects of adjuvanted vaccines administered through the non-mucosal route are poorly understood. Here, we clarify the mechanisms by which no...