A poxvirus ankyrin protein LSDV012 inhibits IFIT1 in a host-species-specific manner by compromising its RNA binding ability

• Published in: PLoS pathogens Vol. 21; no. 3; p. e1012994
• Main Authors: Xie, Shijie, Fang, Yongxiang, Liao, Zhiyi, Cui, Lianxin, Niu, Kang, Ren, Shuning, Zhu, Junda, Wu, Wenxue, Jing, Zhizhong, Peng, Chen
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.03.2025; Public Library of Science (PLoS)
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; Animals; Ankyrin Repeat; Ankyrins - genetics; Ankyrins - metabolism; Biological response modifiers; Biology and Life Sciences; Carrier Proteins - metabolism; Development and progression; DNA virus infections; DNA viruses; Genetic aspects; HEK293 Cells; Host-Pathogen Interactions; Host-virus relationships; Humans; Immune response; Interferon; Interferon Type I - metabolism; Medicine and Health Sciences; Phylogeny; Physiological aspects; Poxviridae - genetics; Poxviridae - metabolism; Research and Analysis Methods; RNA; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; Skin diseases; Viral proteins; Viral Proteins - genetics; Viral Proteins - metabolism; Virus Replication; Virus research; China; Massachusetts

Poxviruses are large DNA viruses with an arsenal of immune-modulatory genes, many of which remain uncharacterized. Proteins with ankyrin repeats are distinct features of poxviruses, although the biological functions of ankyrin proteins are not fully understood. Lumpy skin disease virus (LSDV) encode...